Results 71 to 80 of about 24,709 (211)

Functional expression of a single-chain antibody to ErbB-2 in plants and cell-free systems

Journal of Translational Medicine, 2006
Background Aberrant signaling by ErbB-2 (HER 2, Neu), a member of the human Epidermal Growth Factor (EGF) receptor family, is associated with an aggressive clinical behaviour of carcinomas, particularly breast tumors.
Benevolo Maria, Natali Pier, Martayan Aline, Fraioli Rocco, Tornambé Andrea, Sperandei Maria, Di Donato Monica, Novelli Flavia, Pietraforte Immacolata, Lombardi Alessio, Galeffi Patrizia, Mottolese Marcella, Ylera Francisco, Cantale Cristina, Giacomini Patrizio   +14 more
doaj   +1 more source

A Case Report of Crotalidae Immune F(ab’)2-associated Coagulopathy Recurrence in a Preschool-age Child

Clinical Practice and Cases in Emergency Medicine
Introduction: Pit viper envenomation may cause coagulopathy. The coagulopathy has been treated with crotalidae polyvalent immune fragment antigen-binding (Fab) ovine antivenom for the last few decades in the United States and usually corrects the acute ...
Jean C.Y. Lo, E. Lea Walters, Brian Wolk
doaj   +1 more source

Transfer of engineered biophysical properties between different antibody formats and expression systems [PDF]

, 2017
Recombinant antibodies and their derivatives are receiving ever increasing attention for many applications. Nevertheless, they differ widely in biophysical properties, from stable monomers to metastable aggregation-prone mixtures of oligomers.
Plückthun, Andreas, Schaefer, Jonas V.
core  

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design [PDF]

, 2017
Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules, which retain the specificity of the rodent antibody but ...
Angal, Bole, Borth, Breedveld, Chloe L. Stoyle, David P. Humphreys, Du, Durocher, Ellgaard, Feige, Feige, Freeze, Heath, Hendershot, Hendershot, Hu, Hubbard, Iwamoto, Katharine Cain, Leitzgen, Mains, Mason, Minegishi, Neil J. Bulleid, Nguyen, Paul E. Stephens, Peters, Sam Heywood, Schellenberger, Slanina, Spiess, Thies, Werther, Yang, Zou   +34 more
core   +1 more source

Biological Therapy and Small Molecules for Adults With Crohn's Disease: Systematic Review and Network Meta‐Analysis

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 9, Page 587-599, September 2025.
ABSTRACT First‐line therapeutic approaches for Crohn's disease include immunosuppressants, aminosalicylates, and corticosteroids. However, more than one‐third of patients are resistant to these treatments and require second‐line therapies. Our goal was to synthesize the evidence on the efficacy and safety of biologics and small molecules for inducing ...
Daniela Gorski, Raul Edison Luna Lazo, Dalton de Assis de Souza, Helena Hiemisch Lobo Borba, Roberto Pontarolo, Fernanda Stumpf Tonin   +5 more
wiley   +1 more source

Immunoglobulin domains in Escherichia coli and other enterobacteria: from pathogenesis to applications in antibody technologies [PDF]

, 2012
The immunoglobulin (Ig) protein domain is widespread in nature having a well-recognized role in proteins of the immune system. In this review, we describe the proteins containing Ig-like domains in Escherichia coli and entero-bacteria, reporting their ...
Bluhm, Hendrik, Dickel, Christian, Foletti, Sandra, Umansky, Vladimir   +3 more
core   +2 more sources

The Redox Enzyme Thioredoxin Is Increased in Plasma Extracellular Vesicles From Endurance‐Trained Females in Response to Acute Exercise

The FASEB Journal, Volume 39, Issue 16, 31 August 2025.
This study aimed to identify changes in the proteome of EVs released into circulation by endurance running‐trained females after 60‐min aerobic exercise. Blood samples were collected immediately before and after exercise, and EVs were separated from plasma.
Krizia Sagini, Mughilan Selvarajah, Silvana Romero, Eva Bassols‐Citores, Beatriz Martin‐Gracia, Manuel Ramirez‐Garrastacho, Fabian Rise, Edgars Endzeliņš, Lilite Sadovska, Diāna Skorinkina, Marija Boguševiča, Rudolfs Cešeiko, Mārtiņš Čampa, Aija Klavina, Aija Linē, Alicia Llorente   +15 more
wiley   +1 more source

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Barthel, Diana, Böhm, Sascha, Elsen, Jean van den, Koch, Tina K., Kraiczy, Peter, Reuter, Michael, Skerka, Christine, Zipfel, Peter F.   +7 more
core   +2 more sources

Evaluation of “Difficult‐to‐Express” Monoclonal Antibodies in a CHO‐Based Hybrid Site‐Specific Integration System Under Industrially Relevant Conditions

Biotechnology Journal, Volume 20, Issue 8, August 2025.
Graphical Abstract and Lay Summary Improved understanding of the primary sequence features characteristic of “difficult‐to‐express” mAbs can improve mAb design, candidate selection, and process development decisions. This work uses a flexible recombinase‐mediated cassette exchange system for rapid comparison of low‐expressing mAb sequence variants at ...
Alana C. Szkodny, Kelvin H. Lee
wiley   +1 more source

VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins [PDF]

, 2015
Peer reviewedPublisher ...
Clem, Flajnik, Makrides, Marchalonis, Müller   +4 more
core   +3 more sources