Results 111 to 120 of about 24,903 (156)

Preliminary crystallographic study of the Fc fragment of a monoclonal IgG2b murine immunoglobulin

Journal of Molecular Biology, 1983
The Fe fragment of a gamma 2b murine monoclonal anti-p-azophenylarsonate antibody (R19.9, IgG2b, kappa) has been crystallized. The crystals are tetragonal, space group P41 (or P43) with unit cell dimensions: a = b = 134.3 +/- 1.1 A, c = 144.0 +/- 0.7 A.
Comarmond, M, Tougard, P
openaire   +2 more sources

Investigation of the Cooperative Structure of Fc Fragments from Myeloma Immunoglobulin G

Biochemistry, 1998
The cooperative structure of Fc fragments prepared from myeloma human IgG1 was studied using scanning microcalorimetry and fluorescence at pH 4.2-8.0. It was shown that the first to be melted are CH2 domains whose interaction with each other is rather weak, while that with CH3 domains is strong.
V M, Tischenko, V M, Abramov, V P, Zav'yalov   +2 more
openaire   +2 more sources

IgC Fc fragments induce B cell differentiation and immunoglobulin secretion

Immunology Letters, 1989
We now show that the Fc fragment is capable of inducing B cell differentiation and secretion of immunoglobulins (Igs) in human mononuclear cells from peripheral blood (PBMC). The absolute number of plasma cells observed in all individuals tested is similar.
E D, Carosella, J, Armand
openaire   +2 more sources

Unsusceptibility of recombinant human Fc fragments of immunoglobulin E to thrombin

Human Antibodies, 1996
Human immunoglobulin E (IgE) contains a potential recognition sequence for thrombin protease cleavage at N-terminal end of Cε3 domain responsible for binding to α chain of high affinity Fc receptor for IgE (FcεRICα, but it remains unknown for the enzyme susceptibility.
openaire   +2 more sources

Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1

Journal of Molecular Biology, 2007
Removal of the fucose residue from the oligosaccharides attached to Asn297 of human immunoglobulin G1 (IgG1) results in a significant enhancement of antibody-dependent cellular cytotoxicity (ADCC) via improved IgG1 binding to Fcgamma receptor IIIa. To provide structural insight into the mechanisms of affinity enhancement, we determined the crystal ...
Shigeki, Matsumiya, Yoshiki, Yamaguchi, Jun-ichi, Saito, Mayumi, Nagano, Hiroaki, Sasakawa, Shizuo, Otaki, Mitsuo, Satoh, Kenya, Shitara, Koichi, Kato   +8 more
openaire   +2 more sources

Effective treatment of experimental autoimmune neuritis with Fc fragment of human immunoglobulin

Journal of Neuroimmunology, 2007
IV immunoglobulin (IVIg) and its Fc fragment proved effective in preventing further progression of experimental autoimmune neuritis (EAN) in the rat induced by whole bovine peripheral nerve myelin and shortening disease duration. This effectiveness was associated with significant differences in electrophysiological parameters including less ...
Hsin Hsin, Lin, Min Xia, Wang, Judith M, Spies, John D, Pollard   +3 more
openaire   +2 more sources

ROLE OF Fc FRAGMENTS IN INHIBITION OF XENOGENIC HYPERACUTE REJECTION BY INTRAVENOUS IMMUNOGLOBULIN

Transplantation, 1996
It has been shown that a high dose administration of human intravenous immunoglobulin G (IVIG) prolonged the survival time of xenografted guinea pig heart in the rat. In this study, we compared the effectiveness of intact IVIG (I-IVIG), Fc fragments of IVIG (Fc-IVIG), and F(ab') fragments of IVIG (Fab-IVIG) in preventing xenogenic hyperacute rejection ...
T, Kojima, S, Hayashi, I, Yokoyama, H, Takagi   +3 more
openaire   +2 more sources

Human Immunoglobulin A: Production of an Fc Fragment by an Enteric Microbial Proteolytic Enzyme

The Journal of Immunology, 1973
Summary An Fc fragment has been prepared in good yield by proteolytic cleavage of human secretory and serum myeloma IgA with an enzyme recovered from the human gastrointestinal tract. The naturally occurring enzyme is of microbial origin and its activity is metal dependent.
S K, Mehta, A G, Plaut, N J, Calvanico, T B, Tomasi   +3 more
openaire   +2 more sources

NMR assignments of the N-glycans of the Fc fragment of mouse immunoglobulin G2b glycoprotein

Biomolecular NMR Assignments, 2021
The Fc portion of immunoglobulin G (IgG) promotes defensive effector functions in the immune system by interacting with Fcγ receptors and complement component C1q. These interactions critically depend on N-glycosylation at Asn297 of each CH2 domain, where biantennary complex-type oligosaccharides contain microheterogeneities resulting primarily from ...
Saeko Yanaka, Yoshiki Yamaguchi, Takeshi Takizawa, Yohei Miyanoiri, Rina Yogo, Ichio Shimada, Koichi Kato   +6 more
openaire   +2 more sources

Expression of Fc Fragment Receptors of Immunoglobulin G (Fc?Rs) in Rat Hepatic Stellate Cells

Digestive Diseases and Sciences, 2005
Hepatic stellate cells (HSCs) are now considered the major cell type in the liver mediating the development of liver fibrosis. Recently it was demonstrated that HSCs express membrane proteins involved in antigen presentation. We further evaluate immunological properties of HSCs by examining the expression and function of the Fc fragment of ...
Hong, Shen, Manna, Zhang, Kelly, Kaita, Gerald Y, Minuk, Julia, Rempel, Yuewen, Gong   +5 more
openaire   +2 more sources