Results 111 to 120 of about 732,598 (320)

Biochemical and structural characterization of the human gut microbiome metallopeptidase IgAse provides insight into its unique specificity for the Fab' region of IgA1 and IgA2.

PLoS Pathogens
Human immunoglobulin A (IgA), comprising the isotypes IgA1 and IgA2, protects ~400 m2 of mucosal surfaces against microbial infections but can also lead to aberrant IgA deposits that cause disease. Certain bacteria have evolved peptidases that cleave the
Juan Sebastián Ramírez-Larrota, Pauline Juyoux, Pablo Guerra, Ulrich Eckhard, F Xavier Gomis-Rüth   +4 more
doaj   +1 more source

Allotypic markers of rhesus monkey immunoglobulin G

, 1974
An allotypic specificity, Ma(1) ('Ma' signifies Macaca), of the rhesus monkey IgG is described; it was identified by an alloantiserum, anti Ma(1). Ma(1) is located on Fc fragments of IgG molecules.
Radl, J., Swart, A.C.W., Kruisbeek, A.M.
core  

Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines [PDF]

, 2011
The hemagglutinins (HAs) of human H1 and H3 influenza viruses and avian H5 influenza virus were produced as recombinant fusion proteins with the human immunoglobulin Fc domain.
Temperton, Nigel J., Ian M. Jones, Christopher R. Bailey, Eleonora Molesti, Ren, Junyuan, Jones, Ian M., Temperton, Nigel J, Silvia Loureiro, Pongsathon Phapugrangkul, Junyuan Ren, Wendy S. Barclay, Camilo A. Colaco, Molesti, Eleonora, Barclay, Wendy S., Shelton, Holly, Colaco, Camilo A, Phapugrangkul, Pongsathon, Nigel J. Temperton, Loureiro, Silvia, Barclay, Wendy S, Bailey, Christopher R, Holly Shelton, Jones, Ian, Colaco, Camilo A., Bailey, Christopher R.   +24 more
core   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

The Role of Modified Fc Fragments in Treating Autoimmune Diseases: A Potential Replacement for Intravenous Immunoglobulin [PDF]

, 2020
High-dose (1-2 g/kg) intravenous immunoglobulin (IVIg), and more recently, subcutaneously delivered immunoglobulin (SCIg), are used to treat a variety of autoimmune diseases; however, there are challenges associated with product production and ...
Lewis, Bonnie JB
core  

Synthetic Particulate Subunit Vaccines Co‐Delivering Multiple Antigens Induce Protective Immunity Against Melioidosis

Advanced NanoBiomed Research, EarlyView.
Engineered endotoxin‐free Escherichia coli were used to assemble poly(3‐hydroxybutyrate) (PHB) biopolymer particles displaying multiple conserved Burkholderia pseudomallei antigens via PhaC‐mediated surface presentation. Following formulation with poly(I:C), the particulate vaccines induced antigen‐specific humoral and cellular immune responses ...
Md. Tanvir Kabir, Shuxiong Chen, Justine B. Bendo, Ashley Johnson, Aleksandra W. Debowski, Mitali Sarkar‐Tyson, Bernd H. A. Rehm   +6 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Screening of bispecific antibodies during single cell cloning of recombinant Chinese hamster ovary cell lines to improve titer and product quality

Biotechnology Progress, EarlyView.
Abstract Development of therapeutic bispecific antibodies (BsAbs) poses significant manufacturability challenges associated with correct chain pairing and an increased diversity of impurities. Here we address this with a product quality assessment during cell line development (CLD), forgoing the need for genetic characterization during cell line ...
Molly Robinson, Jessica Willmott, Holly Corrigall, Daniela Lega, Joseph Stirling, Vithiya Vimalraj, Mitul Patel, Robyn Emmins   +7 more
wiley   +1 more source

Expression of single-chain variable fragments fused with the Fc-region of rabbit IgG in Leishmania tarentolae

, 2020
Background: In recent years the generation of antibodies by recombinant methods, such as phage display technology, has increased the speed by which antibodies can be obtained.
†, Peder Madsen, Peter Kristensen, Mathias Lindh Jørgensen, Niels Anton Friis, Jesper Just, Steen Vang Petersen   +6 more
core  

Precision Synthesis of Biomass‐Derived Graphene‐Like Carbon With Tailored Crystallinity via Controlled Flash Joule Heating

Carbon Energy, EarlyView.
A dual‐phase flash Joule heating strategy converts pre‐pyrolyzed biomass into structurally tunable carbon materials from waste feedstocks. By decoupling current‐driven thermodynamic input and duration‐dependent kinetic relaxation, the process maps the transition from amorphous carbon to few‐layer turbostratic graphene and turbostratic nanographite ...
Jiawen Zeng, Yichen Dong, Niyuan Zhu, Danchen Zhu, Hao Jiang, Yingquan Chen, Tong Han, Yonggang Yao, Hanping Chen, Haiping Yang   +9 more
wiley   +1 more source