Results 91 to 100 of about 732,598 (320)

Figure 2: Cross-Linking of GPVI-Fc With Anti–Human-Fc IgG and Anti–Human-Fc Fab2 Increases Inhibition of Static Platelet Aggregation Induced by Collagen or Plaque Compared With GPVI-Fc

, 2019
(A) Bar diagrams show the effects of glycoprotein VI–fragment crystallizable (GPVI-Fc) (20 μg/ml; 133 nM), GPVI-Fc, and Fc cross-linked (XL) with anti–human-Fc immunoglobulin G (IgG) (GPVI-Fc*IgG-XL, Fc*IgG-XL; 133 nM) (left panels) or with anti–human-Fc
Kerstin Uhland (2092060), Reinhard Lorenz (6820967), Remco T.A. Megens (6820955), Shachar Sherman (6820961), Natalie Elia (660866), Mariaelvy Bianchini (6820958), Christine John (839705), Götz Münch (436471), Wolfgang Siess (168198), Johannes Buchner (277160), Alexander Faussner (781036), Christian Weber (86566), Martin Ungerer (436470), Richard Brandl (6820964), Janina Jamasbi (6820952)   +14 more
core   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

Allosteric inhibition of IgE–FcεRI interactions by simultaneous targeting of IgE F(ab’)2 epitopes

Communications Biology
Immunoglobulin E (IgE) plays pivotal roles in allergic diseases through interaction with a high-affinity receptor (FcεRI). We established that Fab fragments of anti-IgE antibodies (HMK-12 Fab) rapidly dissociate preformed IgE-FcεRI complexes in a ...
Takao Hirano, Akemi Koyanagi, Hideo Ago, Masaki Yamamoto, Jiro Kitaura, Masataka Kasai, Ko Okumura   +6 more
doaj   +1 more source

Fc Glycan-Modulated Immunoglobulin G Effector Functions [PDF]

, 2019
Immunoglobulin G (IgG) molecules are glycoproteins and residues in the sugar moiety attached to the IgG constant fragment (Fc) are essential for IgG functionality such as binding to cellular Fc receptors and complement activation.
Quast, Isaak, Lünemann, Jan
core  

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Overview of different antibody fragments and effect of reconstituted Nb_An05-Fc on in vitro mediated trypanolysis.

, 2013
(A) Schematic of the different antibody fragments. (1) Nbs are derived from the HCAbs after cloning and selection by phage-display. (2) The monoclonal Nb is reconstituted into an HCAb molecule.
Benoît Stijlemans (119880), Lea Brys (349654), Patrick De Baetselier (52141), Serge Muyldermans (24113), Mark C. Field (129657), David Pérez-Morga (2886368), Jeremy N. Skepper (164101), Etienne Pays (256328), Senthil Kumar A. Natesan (259144), Guy Caljon (119879), Stefan Magez (52136), Katja Conrath (349652), Dirk Saerens (119881), Alexandros Nikolaou (349653)   +13 more
core   +1 more source

Expression of single-chain variable fragments fused with the Fc-region of rabbit IgG in Leishmania tarentolae

Microbial Cell Factories, 2014
BackgroundIn recent years the generation of antibodies by recombinant methods, such as phage display technology, has increased the speed by which antibodies can be obtained.
M. Jørgensen, Niels Anton Friis, J. Just, P. Madsen, S. Petersen, P. Kristensen   +5 more
semanticscholar   +1 more source

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

Advanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia, Giulia E. M. Ammirati, Sophie Herzog, Tommy Krug, Nico Strohmeyer, Miguel Camacho Rufino, Matthias P. Lutolf, David A. Weitz, Daniel J. Müller   +8 more
wiley   +1 more source

IgA in the horse: cloning of equine polymeric Ig receptor and J chain and characterization of recombinant forms of equine IgA [PDF]

, 2010
As in other mammals, immunoglobulin A (IgA) in the horse has a key role in immune defense. To better dissect equine IgA function, we isolated complementary DNA (cDNA) clones for equine J chain and polymeric Ig receptor (pIgR).
Wagner, B., R M Irvine, Woof, JM, J M Woof, Irvine, R. M., Lewis, MJ, Woof, Jennifer M., Lewis, Melanie J., B Wagner, Wagner, B, Irvine, RM, M J Lewis   +11 more
core   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source