Results 81 to 90 of about 732,598 (320)

Structural basis for Fc receptor recognition of immunoglobulin M [PDF]

, 2023
Immunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and play critical roles in regulating immune responses by activation of immune cells, clearance of immune complexes and regulation of ...
Menon, Rajesh P, Tolar, Pavel, Chen, Qu, Rosenthal, Peter B, Masino, Laura   +4 more
core   +1 more source

A perspective on the structure and receptor-binding properties of immunoglobulin G Fc

Biochemistry, 2015
Recombinant antibodies spurred a revolution in medicine that saw the introduction of powerful therapeutics for treating a wide range of diseases, from cancers to autoimmune disorders and transplant rejection with more applications looming on the horizon.
Quinlin M Hanson, A. Barb
semanticscholar   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

Advanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu, Wen Zhang, Lunxin Liu, Lan Gui, Yumei Qin, Xiaohui Yang, Longjian Zhang, Chaohua Wang, Jinpeng Hu, Gaoyang Guo, Qing Jiang, Jin Wang, Li Yang, Bo Zhang, Yunbing Wang   +14 more
wiley   +1 more source

Protective effects of an Fc-engineered PD-L1 fusion protein in a spontaneous abortion model and a Th17 cell–induced pregnancy loss model

Frontiers in Pharmacology
The binding of programmed death-ligand 1 (PD-L1) with its receptor PD-1 has been proven to negatively regulate immune responses. Here, we assessed the therapeutic effects of Fc-fused PD-L1 protein on foetomaternal tolerance using a murine spontaneous ...
Guangyao Li, Guangyao Li, Guangyao Li, Tiantian Wang, Dan Tan, Yamin Jin, Xuemei Zhou, Hongru Ai, Xinya Zheng, Xiaochen Ren, Shi Hu, Shi Hu, Changhai Lei, Wenyan Fu, Wenyan Fu   +14 more
doaj   +1 more source

INTERACTION BETWEEN DIFFERENT MOLECULAR FORMS OF IMMUNOGLOBULIN A AND RECOMBINANT DERIVATIVES POLYPEPTIDES OF BAC RECEPTOR PROTEINS FROM GROUP B STREPTOCOCCI

Медицинская иммунология, 2014
. The article concerns interactions between immunoglobulin A and recombinant P6, P7, P8 polypeptides, designed on the basis of externally localized Bac protein of the Group B streptococci, possessing IgA-binding activity.There is a current demand for ...
A. S. Korzhueva, D. G. Ibragimova, I. A. Ustinovich, Artem A. Totolian, M. P. Samoilovich, A. N. Suvorov   +5 more
doaj   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

TFPI-2 Protects Against Gram-Negative Bacterial Infection

Frontiers in Immunology, 2018
Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix.
Mohamad N. Ali, Mohamad N. Ali, Gopinath Kasetty, Malin Elvén, Saud Alyafei, Sandra Jovic, Arne Egesten, Heiko Herwald, Artur Schmidtchen, Artur Schmidtchen, Artur Schmidtchen, Praveen Papareddy, Praveen Papareddy   +12 more
doaj   +1 more source

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source

Environmental Enteric Dysfunction Includes a Broad Spectrum of Inflammatory Responses and Epithelial Repair ProcessesSummary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: Environmental enteric dysfunction (EED), a chronic diffuse inflammation of the small intestine, is associated with stunting in children in the developing world.
Jinsheng Yu, M. Isabel Ordiz, Jennifer Stauber, Nurmohammad Shaikh, Indi Trehan, Erica Barnell, Richard D. Head, Ken Maleta, Phillip I. Tarr, Mark J. Manary   +9 more
doaj   +1 more source