Results 71 to 80 of about 51,044 (202)

TFPI-2 Protects Against Gram-Negative Bacterial Infection

Frontiers in Immunology, 2018
Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix.
Mohamad N. Ali, Mohamad N. Ali, Gopinath Kasetty, Malin Elvén, Saud Alyafei, Sandra Jovic, Arne Egesten, Heiko Herwald, Artur Schmidtchen, Artur Schmidtchen, Artur Schmidtchen, Praveen Papareddy, Praveen Papareddy   +12 more
doaj   +1 more source

Environmental Enteric Dysfunction Includes a Broad Spectrum of Inflammatory Responses and Epithelial Repair ProcessesSummary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: Environmental enteric dysfunction (EED), a chronic diffuse inflammation of the small intestine, is associated with stunting in children in the developing world.
Jinsheng Yu, M. Isabel Ordiz, Jennifer Stauber, Nurmohammad Shaikh, Indi Trehan, Erica Barnell, Richard D. Head, Ken Maleta, Phillip I. Tarr, Mark J. Manary   +9 more
doaj   +1 more source

Viruses disrupt functions of human lymphocytes. Effects of measles virus and influenza virus on lymphocyte-mediated killing and antibody production. [PDF]

, 1984
We present experimental data that offer, in part, a better understanding of the immunosuppression that accompanies measles virus infection. We note that measles virus "silently" infects human lymphocytes and that the infection does not alter lymphocyte ...
Casali, P, Oldstone, MB, Rice, GP
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Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. [PDF]

, 1994
Polyreactive antibodies (Abs) constitute a major proportion of the early Ab repertoire and are an important component of the natural defense mechanisms against infections.
Casali, P, Ichiyoshi, Y
core   +1 more source

Allosteric inhibition of IgE–FcεRI interactions by simultaneous targeting of IgE F(ab’)2 epitopes

Communications Biology
Immunoglobulin E (IgE) plays pivotal roles in allergic diseases through interaction with a high-affinity receptor (FcεRI). We established that Fab fragments of anti-IgE antibodies (HMK-12 Fab) rapidly dissociate preformed IgE-FcεRI complexes in a ...
Takao Hirano, Akemi Koyanagi, Hideo Ago, Masaki Yamamoto, Jiro Kitaura, Masataka Kasai, Ko Okumura   +6 more
doaj   +1 more source

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

Gene expression and splicing alterations analyzed by high throughput RNA sequencing of chronic lymphocytic leukemia specimens. [PDF]

, 2015
BackgroundTo determine differentially expressed and spliced RNA transcripts in chronic lymphocytic leukemia specimens a high throughput RNA-sequencing (HTS RNA-seq) analysis was performed.MethodsTen CLL specimens and five normal peripheral blood CD19+ B ...
A Ameur, A Choudhury, A Hidalgo, A Rosenwald, AS Kamiguti, C Haslinger, C Soo, C Trapnell, C Trapnell, CJ David, DC Gilby, E Moon, E Moravcikova, F Colotta, F Talab, FC Kelleher, Gwen Jordaan, H Dohner, H Jiang, J Eswaran, J Vilpo, JC Marioni, JJ Dongen van, JP Venables, K Inada, K Zen, L Chen, L Wang, L Yang, LQ Zhang, M Crespo, M Rehli, M Shinohara, M Sultan, Matteo Pelegrini, ML Hermiston, MW Pfaffl, N Chiorazzi, NA Twine, O Bermudez, P Guglielmi, P Kapranov, PG Ferreira, Phillipp Nham, Q Huang, RA Higgins, RI Fernando, RK Gandhirajan, RN Damle, Ryan T. Phan, S Anders, S Courtois, S Decker, S Falt, S Ibrahim, S Liu, S Ma, S Ren, S Shen, Sanjai Sharma, SM Russell, SP Shah, SR Gunn, T Ormsby, TJ Hamblin, U Klein, V Quesada, Wei Liao, XS Puente, Y Pawitan, Y Pekarsky, Y Yu, Z Wang   +72 more
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Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by gamma/delta and alpha/beta thymic cell lines. [PDF]

, 1987
After culture in IL-2, thymocytes expressing either TCR-alpha/beta or -gamma/delta acquired the ability to lyse hematopoietic and solid tumor cell targets without deliberate immunization or apparent restriction by the MHC.
Gemlo, BT, Lanier, LL, Phillips, JH, Rayner, AA, Weiss, A   +4 more
core   +1 more source

Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules [PDF]

, 1997
Major histocompatibility complex (MHC) class II molecules are transported to intracellular MHC class II compartments via a transient association with the invariant chain (Ii).
Ferrari, G., Knight, A. M., Watts, C., Pieters, J.   +3 more
core   +1 more source

The structures of secretory and dimeric immunoglobulin A [PDF]

, 2020
Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds pathogens and commensal microbes. SIgA is a polymeric antibody, typically containing two copies of IgA that assemble with one joining-chain (JC) to form dimeric (d) IgA ...
Haloi, Nandan, Huey-Tubman, Kathryn E., Kumar Bharathkar, Sonya, Malyutin, Andrey G., Parker, Benjamin W., Stadtmueller, Beth M., Tajkhorshid, Emad   +6 more
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