Results 61 to 70 of about 51,044 (202)
A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. [PDF]
, 2015 Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain.
Caddick, S +5 more
core +1 more source
Vascular endothelial growth factor trap-eye and trap technology: Aflibercept from bench to bedside
Oman Journal of Ophthalmology, 2014 Anti-vascular endothelial growth factor (VEGF) currently used to treat eye diseases have included monoclonal antibodies, antibody fragments, and an aptamer.
Ali M Al-Halafi
doaj +1 more source
Scientific Reports, 2023 Abstract Proinsulin Like Growth Factor I (prolGF-I) and myostatin (Mstn) regulate muscle regeneration and mass when intravenously delivered. We tested if chloroplast bioencapsulated forms of these proteins may serve as a non-invasive means of drug delivery through the digestive system. We created tobacco (
Lisa LaManna +4 more
openaire +4 more sources
The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]
, 2003 We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Hadlington, Jane L. +6 more
core +1 more source
Bordetella parapertussis Survives inside Human Macrophages in Lipid Raft-Enriched Phagosomes [PDF]
, 2014 Bordetella parapertussis is a human pathogen that causes whooping cough. The increasing incidence of B. parapertussis has been attributed to the lack of cross protection induced by pertussis vaccines. It was previously shown that B. parapertussis is able
Gorgojo, Juan Pablo +2 more
core +3 more sources
High-level fed-batch fermentative expression of an engineered Staphylococcal protein A based ligand in E. coli: purification and characterization [PDF]
, 2015 The major platform for high level recombinant protein production is based on genetically modified microorganisms like Escherichia coli (E. coli) due to its short dividing time, ability to use inexpensive substrates and additionally, its genetics is ...
Fernández Lahore, Marcelo +5 more
core +1 more source
Non-specific binding of antibodies in immunohistochemistry: Fakes and facts [PDF]
, 2011 Protocols for blocking non-specific antibody (Ab) binding in immunohistochemistry are based on rather contradictory and outdated reports. This prompted us to prove, whether non-specific Ab binding may really lead to unwanted background staining in ...
Igor Buchwalow +3 more
core +1 more source
Human Schistosome Infection and Allergic Sensitisation [PDF]
, 2012 Several field studies have reported an inverse relationship between the prevalence of helminth infections and that of allergic sensitisation/atopy. Recent studies show that immune responses induced by helminth parasites are, to an extent, comparable to ...
Mutapi, Francisca +2 more
core +3 more sources
Frontiers in PharmacologyThe binding of programmed death-ligand 1 (PD-L1) with its receptor PD-1 has been proven to negatively regulate immune responses. Here, we assessed the therapeutic effects of Fc-fused PD-L1 protein on foetomaternal tolerance using a murine spontaneous ...
Guangyao Li +14 more
doaj +1 more source
Медицинская иммунология, 2014 . The article concerns interactions between immunoglobulin A and recombinant P6, P7, P8 polypeptides, designed on the basis of externally localized Bac protein of the Group B streptococci, possessing IgA-binding activity.There is a current demand for ...
A. S. Korzhueva +5 more
doaj +1 more source