Results 41 to 50 of about 732,598 (320)

Emerging therapies in the medical management of thyroid eye disease

Frontiers in Ophthalmology, 2023
IntroductionThyroid eye disease (TED) is an immune-mediated disorder associated with a heterogenous array of manifestations that may unfavorably impact vision and quality of life.
Alisha Kamboj, Andrew R. Harrison, Andrew R. Harrison, Ali Mokhtarzadeh   +3 more
doaj   +1 more source

Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum [PDF]

, 2001
Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 ...
David R. Cavanagh, Cavanagh, D R, Ibrahim M. Elhassan, Elhassan, I M, Jana S. McBride, Kevin Marsh, Elhassan, A, Hviid, L, Khalil, E A T G, Ahmed Elhassan, Thor G. Theander, Cavanagh, David, Marsh, K, David E. Arnot, E. At Tahir G. Khalil, McBride, J S, Arnot, D E, Theander, T G, Lars Hviid, Dobano, C, Carlota Dobaño, Khalil, E A   +21 more
core   +1 more source

Modified recombinant human IgG1‐Fc is superior to natural intravenous immunoglobulin at inhibiting immune‐mediated demyelination [PDF]

, 2021
Intravenous immunoglobulin (IVIG) is an established treatment for numerous autoimmune conditions. Although Fc fragments derived from IVIG have shown efficacy in controlling immune thrombocytopenia (ITP) in children, the mechanisms of action are unclear ...
Dell, Anne, Blundell, Pat, Goebels, Norbert, Pleass, Richard J, Kohl, Alain, Stuart Haslam, Norbert Goebels, Alain Kohl, Schultz, Verena, Da Silva Filipe, Ana, Pat Blundell, Quan Gu, Jiabin Wang, Lu, Dongli, Baksmeier, Christine, Gu, Quan, Ana Da Silva Filipe, Linnington, Chris, Verena Schultz, Dan Czajkowsky, Haslam, Stuart, Pleass, Richard, Steckel, Julia, Czajkowsky, Dan, Christine Baksmeier, Wang, Jiabin, Dongli Lu, Richard J. Pleass, Anne Dell, Julia Steckel, Chris Linnington   +30 more
core   +1 more source

Studies investigating peripheral blood derived cells that express the high affinity receptor for immunoglobulin E (Fc?RI) In Allergic Disorders

, 2008
It is just forty years since the identification of immunoglobulin E (IgE) as the reagin responsible for allergen induced immediate hypersensitivity reactions.
Sihra, Bhupinder Singh
core   +2 more sources

Investigating protein–excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy

mAbs, 2022
Multispecific therapeutic proteins come in a variety of formats, including bi- and tri-specific antibodies, dual-variable domain antibodies, and CrossMabs.
Jainik Panchal, Bradley T. Falk, Valentyn Antochshuk, Mark A. McCoy   +3 more
doaj   +1 more source

Structure analysis of goose immunoglobulin Y Fc fragment

Central European Journal of Immunology, 2013
<b>Objective:</b> Goose immunoglobulin Y (IgY)-Fc fragment gene is cloned.<br /> <b>Material and methods</b>: In order to obtain a certain length (106 bp) of constant domain gene, a pair of primer was designed according to the conserved nucleotide sequence of duck (CAA46322) and chicken (S00390) IgY-Fc fragment that was ...
Lei Jiang, Wei-Shan Chang, Hao Guo, Peng Sun, Xiu-Mei Dai   +4 more
openaire   +1 more source

Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats

Frontiers in Molecular Biosciences, 2022
As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies and other new formats, represent a key component in advancing antibody therapy.
Monica L. Fernández-Quintero, Patrick K. Quoika, Florian S. Wedl, Clarissa A. Seidler, Katharina B. Kroell, Johannes R. Loeffler, Nancy D. Pomarici, Valentin J. Hoerschinger, Alexander Bujotzek, Guy Georges, Hubert Kettenberger, Klaus R. Liedl   +11 more
doaj   +1 more source

Reversible Dissociation of Fragment Fc of Rabbit γG-Immunoglobulin

Journal of Biological Chemistry, 1966
Abstract Crystallized Fragment Fc of rabbit γG-globulin, prepared by digestion with papain in the presence of 0.05 m l-cysteine, dissociates into half-fragments in 0.05 m NaCl at pH 2.7. Dissociation is approximately half-complete at pH 3.1. The conditions are similar to those required for dissociation of γG-globulin into half-molecules, which supports
F.P. Inman, A. Nisonoff
openaire   +1 more source

Fc Glycan-Modulated Immunoglobulin G Effector Functions [PDF]

, 2014
Immunoglobulin G (IgG) molecules are glycoproteins and residues in the sugar moiety attached to the IgG constant fragment (Fc) are essential for IgG functionality such as binding to cellular Fc receptors and complement activation.
Jan D. Lünemann, Quast, Isaak, Isaak Quast, Lünemann, Jan D, Lünemann JD, Quast I   +5 more
core   +1 more source

Studies investigating peripherial blood derived cells that express the high affinity receptor for immunoglobulin E (FceRI) in allergic disorders

, 2008
It is just forty years since the identification of immunoglobulin E (IgE) as the reagin responsible for allergen induced immediate hypersensitivity reactions.
Sihra, Bhupinder Singh
core   +2 more sources