Results 21 to 30 of about 51,044 (202)

Russell-like bodies in plant seeds share common features with prolamin bodies and occur upon recombinant protein production [PDF]

, 2019
Although many recombinant proteins have been produced in seeds at high yields without adverse effects on the plant, endoplasmic reticulum (ER) stress and aberrant localization of endogenous or recombinant proteins have also been reported.
Arcalis, Elsa, Avesani, Linda, Bortesi, Luisa, De Meyer, Thomas, de meyer, thomas, Depicker, Anna, Hilscher, Julia, Ibl, Verena, Morandini, Francesca, Pezzotti, Mario, Pum, Dietmar, Rademacher, Thomas, Stoger, Eva, Vitale, Alessandro   +13 more
core   +2 more sources

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design [PDF]

, 2017
Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules, which retain the specificity of the rodent antibody but ...
Angal, Bole, Borth, Breedveld, Chloe L. Stoyle, David P. Humphreys, Du, Durocher, Ellgaard, Feige, Feige, Freeze, Heath, Hendershot, Hendershot, Hu, Hubbard, Iwamoto, Katharine Cain, Leitzgen, Mains, Mason, Minegishi, Neil J. Bulleid, Nguyen, Paul E. Stephens, Peters, Sam Heywood, Schellenberger, Slanina, Spiess, Thies, Werther, Yang, Zou   +34 more
core   +1 more source

Enzymic degradation of the Fc fragment of rabbit immunoglobulin IgG [PDF]

Biochemical Journal, 1967
The digestion of the Fc fragment of rabbit immunoglobulin IgG by several proteolytic enzymes was investigated by using gel filtration and starch-gel electrophoresis in 8m-urea-formate as criteria of the extent of degradation. Though fragment Fc and mildly reduced fragment Fc proved resistant to tryptic hydrolysis, papain and pepsin cleaved the fragment
openaire   +2 more sources

Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1 [PDF]

, 2015
Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including autism and language impairment.
Comoletti, Davide, Daake, Sventja von, DE JACO, Antonella, Demeler, Borries, Ellisman, Mark H., Jeffries, Cy M., Pakos, Irene S., Perkins, Guy, Ranaivoson, Fanomezana M., Rubio Marrero, Eva N., Shaikh, Tanvir R., Trewhella, Jill, Vincelli, Gabriele   +12 more
core   +1 more source

Lupus serum IgG induces microglia activation through Fc fragment dependent way and modulated by B-cell activating factor

Journal of Translational Medicine, 2019
Background Neuropsychiatric manifestations are frequent in patients with systemic lupus erythematosus (SLE), yet the etiology and pathogenesis of brain damage in SLE remains unclear.
Chunshu Yang, Xiaoyu Hou, Qianhui Feng, Yingzhuo Li, Xuejiao Wang, Ling Qin, Pingting Yang   +6 more
doaj   +1 more source

Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. [PDF]

, 1993
We have generated transgenic mice that express the immunoglobulin (Ig)M heavy chain and kappa light chain genes coding for a human IgM rheumatoid factor (RF), Les.
Carson, DA, Chen, PP, Jirik, FR, Kipps, TJ, Roudier, J, Tighe, H, Tucker, R   +6 more
core   +2 more sources

Full-length recombinant antibodies from Escherichia coli: production, characterization, effector function (Fc) engineering, and clinical evaluation

mAbs, 2022
Although several antibody fragments and antibody fragment-fusion proteins produced in Escherichia coli (E. coli) are approved as therapeutics for various human diseases, a full-length monoclonal or a bispecific antibody produced in E.
Md Harunur Rashid
doaj   +1 more source

Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12

Cell Reports, 2013
The human immunoglobulin G (IgG) 2G12 recognizes high-mannose carbohydrates on the HIV type 1 (HIV-1) envelope glycoprotein gp120. Its two antigen-binding fragments (Fabs) are intramolecularly domain exchanged, resulting in a rigid (Fab)2 unit including ...
Yunji Wu, Anthony P. West, Jr., Helen J. Kim, Matthew E. Thornton, Andrew B. Ward, Pamela J. Bjorkman   +5 more
doaj   +1 more source

Intracellular Antibodies for Drug Discovery and as Drugs of the Future

Antibodies, 2023
The application of antibodies in cells was first shown in the early 1990s, and subsequently, the field of intracellular antibodies has expanded to encompass antibody fragments and their use in target validation and as engineered molecules that can be ...
T. H. Rabbitts
doaj   +1 more source

Serum levels of matrix metalloproteinases-2 and-9 and their tissue inhibitors in inflammatory neuromuscular disorders [PDF]

, 2006
We monitored serum levels of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) before and during intravenously applied immunoglobulin (IVIG) therapy in 33 patients with chronic immune-mediated neuropathies and myopathies and 15 ...
B.G.H. Schoser, Carmeli E, Choi YC, D. Pongratz, Demestre M, Hartung HP, Kieseier BC, Kugler A, Lee MA, Mirowska D, S. Hurnaus, Schoser BGH, Shapiro S, Sharshar T, W. Mueller-Felber, Wiles CM   +15 more
core   +1 more source