Results 31 to 40 of about 24,903 (156)

Gamma-globulin Inhibits Superantigen-induced Lymphocyte Proliferation and Cytokine Production

Allergology International, 2007
Background: High-dose pooled human immunoglobulin (PHIG) treatment is sometimes effective in superantigen related inflammatory diseases, such as toxic shock syndrome and Kawasaki disease.
Kumiko Kato, Tatsuo Sakamoto, Komei Ito
doaj   +1 more source

Customized extracellular vesicles targeting lysosomal biogenesis deliver therapeutic cargo for intervertebral disc degeneration treatment

Journal of Nanobiotechnology
Extracellular vesicles (EVs) have gained prominence as advanced drug delivery systems due to their inherent merits. Recent advancements highlight their utility in transporting therapeutic proteins with significant progress in targeted therapies.
Zhiwei Liao, Zixuan Ou, Bide Tong, Shuai Li, Cao Yang   +4 more
doaj   +1 more source

Altered IgG N-Glycosylation at Onset of Type 1 Diabetes in Children Is Predominantly Driven by Changes in the Fab N-Glycans

Biomedicines
Background: N-glycosylation is a post-translational modification involving the attachment of oligosaccharides to proteins and is known to influence immunoglobulin G (IgG) effector functions and even antigen binding.
Branimir Plavša, Najda Rudman, Flemming Pociot, Olga Gornik   +3 more
doaj   +1 more source

Staphylococcus pseudintermedius Sbi paralogs inhibit complement and bind IgM, IgG Fc and Fab.

PLoS ONE, 2019
The success of staphylococci as pathogens has been attributed, in part, to their ability to evade their hosts' immune systems. Although the proteins involved in evasion have been extensively studied in staphylococci affecting humans little ...
Alaa H Sewid, M Nabil Hassan, A M Ammar, David A Bemis, Stephen A Kania   +4 more
doaj   +1 more source

Production and characterization of monoclonal antibodies anti fragment Fc of bovine IgG

Brazilian Archives of Biology and Technology, 2010
The aim of this work was to produce and characterize monoclonal antibodies anti bovine immunoglobulin G (IgG). Out of seven hybridomas, two were chosen based on the ELISA'S absorbance values and were labeled B4F11 and B3H12.
Tânia Regina Penha, Ernesto Renato Krüger, Vanete Thomaz-Soccol, Jorge Victor Bacila Agottani, Flávio Hiroshi Itano, Ludmilla Della Coletta Troiano, Josiane Brodzinski   +6 more
doaj   +1 more source

Subfragments from the Fc fragment of human immunoglobulin G. Isolation and physicochemical characterization [PDF]

Biochemical Journal, 1968
A fragment termed fragment Fc′ and a related fragment termed fragment pFc′ produced by the actions of papain and pepsin respectively on human immunoglobulin G have been isolated and characterized. Amino acid analyses and experiments utilizing cyanogen bromide to cleave the methionyl bonds of the Fc′ and pFc′ fragments make it possible to locate both ...
M W, Turner, H, Bennich
openaire   +2 more sources

Vascular endothelial growth factor trap-eye and trap technology: Aflibercept from bench to bedside

Oman Journal of Ophthalmology, 2014
Anti-vascular endothelial growth factor (VEGF) currently used to treat eye diseases have included monoclonal antibodies, antibody fragments, and an aptamer.
Ali M Al-Halafi
doaj   +1 more source

Immunoglobulin G Fc Fragment‐Binding Proteins in Mycoplasma salivarium Cells [PDF]

Microbiology and Immunology, 1992
AbstractCell proteins of Mycoplasma salivarium were separated by sodium dodecyl sulfate‐polyacrylamide gel electrophoresis, transferred to membranes, then examined for reactivity with human IgG molecules, the Fc fragment of human IgG, and concanavalin A (ConA). Multiple protein bands bound IgG, and most of them also bound ConA.
Y, Sawa, T, Watanabe, K, Shibata
openaire   +2 more sources

Conformation changes and dissociation of Fc fragments of rabbit immunoglobulin G as a function of pH [PDF]

Biochemical Journal, 1969
1. The sedimentation coefficients of rabbit immunoglobulin G, four types of Fc fragments, univalent Fab and bivalent F(ab)2 fragments were measured as a function of pH. 2. In conjunction with molecular-weight determinations by sedimentation equilibrium, and with the behaviour on gel filtration, this enabled the state of association of the Fc fragments ...
P A, Charlwood, S, Utsumi
openaire   +2 more sources

Protective effects of an Fc-engineered PD-L1 fusion protein in a spontaneous abortion model and a Th17 cell–induced pregnancy loss model

Frontiers in Pharmacology
The binding of programmed death-ligand 1 (PD-L1) with its receptor PD-1 has been proven to negatively regulate immune responses. Here, we assessed the therapeutic effects of Fc-fused PD-L1 protein on foetomaternal tolerance using a murine spontaneous ...
Guangyao Li, Guangyao Li, Guangyao Li, Tiantian Wang, Dan Tan, Yamin Jin, Xuemei Zhou, Hongru Ai, Xinya Zheng, Xiaochen Ren, Shi Hu, Shi Hu, Changhai Lei, Wenyan Fu, Wenyan Fu   +14 more
doaj   +1 more source