Results 11 to 20 of about 732,598 (320)

Immunoglobulin Fc heterodimer platform technology: From design to applications in therapeutic antibodies and proteins [PDF]

Frontiers in Immunology, 2016
The monospecific and bivalent characteristics of naturally occurring immunoglobulin G (IgG) antibodies depend on homodimerization of the fragment crystallizable (Fc) regions of two identical heavy chains (HCs) and the subsequent assembly of two identical
Ji-Hee Ha, Jung-Eun Kim, Yong-Sung Kim
doaj   +3 more sources

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity [PDF]

Frontiers in Immunology, 2017
Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke, Christian W. Keller, Patrick Weber, Isaak Quast, Isaak Quast, Jan D. Lünemann, Jan D. Lünemann   +6 more
doaj   +4 more sources

Improvement of the method of obtaining human IgA Fc-fragments [PDF]

Regulatory Mechanisms in Biosystems, 2015
To address a number of fundamental and applied problems in immunology, molecular and cellular biology and biotechnology it is necessary to obtain Fc-fragments of immunoglobulins.
O. Y. Galkin, Y. V. Gorshunov, V. F. Solovjova   +2 more
doaj   +2 more sources

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Nature Communications, 2022
Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus, Erwin Pannecoucke, Elvera J. van der Kooi, Arthur E. H. Bentlage, Ninotska I. L. Derksen, Julie Andries, Bianca Balbino, Magdalena Sips, Peter Ulrichts, Peter Verheesen, Hans de Haard, Theo Rispens, Savvas N. Savvides, Gestur Vidarsson   +13 more
doaj   +2 more sources

Fragments of bacterial endoglycosidase S and immunoglobulin G reveal subdomains of each that contribute to deglycosylation [PDF]

Journal of Biological Chemistry, 2014
Endoglycosidase S (EndoS) is a glycoside-hydrolase secreted by the bacterium Streptococcus pyogenes. EndoS preferentially hydrolyzes the N-linked glycans from the Fc region of IgG during infection. This hydrolysis impedes Fc functionality and contributes
Yu, Xiaojie, Crispin, Max, Vesiljevic, Snezana, Pritchard, Laura K., Mattick, Susan, Scanlan, Christopher N., Baruah, Kavitha, Schnell, Jason R., Higgins, Matthew K., Krishna, Benjamin, Harvey, David J., Dixon, Emma V., Claridge, Jolyon K., Zitzmann, Nicole   +13 more
core   +2 more sources

Conformation changes and dissociation of Fc fragments of rabbit immunoglobulin G as a function of pH [PDF]

Biochemical Journal, 1969
1. The sedimentation coefficients of rabbit immunoglobulin G, four types of Fc fragments, univalent Fab and bivalent F(ab)2 fragments were measured as a function of pH. 2. In conjunction with molecular-weight determinations by sedimentation equilibrium, and with the behaviour on gel filtration, this enabled the state of association of the Fc fragments ...
P A, Charlwood, S, Utsumi
openaire   +3 more sources

Differential binding characteristics of protein G and protein A for Fc fragments of papain-digested mouse IgG

Immunology Letters, 2003
It has been previously reported that staphylococcal protein A (SPA) bound only to the Fc region of mouse immunoglobulin G. (IgG) and streptococcal protein G (SPG) bound to both Fab and Fc regions of mouse IgG and the binding sites for SPG and SPA on Fc ...
Aybay, C
core   +2 more sources

Effect of IgG fragments in IVIG(pH4)on phagocytosis of sensitized erythrocytes by macrophage

Zhongguo shuxue zazhi, 2022
Objective To research the effect of the Fc, Fab and F(ab′)2 fragments of immunoglobulin G, the main components of Human Immunoglobulin(pH4) for Intravenous Injection(IVIG), on the phagocytic function of macrophages derived from THP-1 cells. Methods First
Liyuan ZHU, Wei ZHANG, Mingxia HOU, Qin LIU, Yuyan QIN, Li Ma, Changqing LI   +6 more
doaj   +1 more source

The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies

Frontiers in Immunology, 2021
Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies.
C. Monnet, E. Jacque, C. de Romeuf, A. Fontayne, Toufik Abache, N. Fournier, G. Dupont, Delphine Derache, Anaïs Engrand, Aurélien Bauduin, A. Terrier, Alexander Seifert, Cécile Beghin, Alain Longue, N. Masiello, Laetitia Danino, M. Nogré, Anais Raia, F. Dhainaut, L. Fauconnier, D. Togbe, C. Reitinger, F. Nimmerjahn, W. Stevens, S. Chtourou, P. Mondon   +25 more
semanticscholar   +1 more source

Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing

Scientific Reports, 2021
A major class of bispecific antibodies (BsAbs) utilizes heterodimeric Fc to produce the native immunoglobulin G (IgG) structure. Because appropriate pairing of heavy and light chains is required, the design of BsAbs produced through recombination or ...
Hiroki Akiba, Tomoko Ise, Satoshi Nagata, Haruhiko Kamada, Hiroaki Ohno, Kouhei Tsumoto   +5 more
doaj   +1 more source