Results 131 to 140 of about 90,091 (319)
Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases
Advanced Science, EarlyView.This article reviews the use of fecal microbiota transplantation (FMT) to treat intestinal diseases like recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), and irritable bowel syndrome (IBS). It discusses FMT's efficacy, influencing factors such as donor selection, recipient characteristics, and treatment protocols ...
Shuna Hou +4 more
wiley +1 more source
Diversity against adversity: How adaptive immunity evolves potent antibodies [PDF]
arXiv, 2008 How does immune system evolve functional proteins - potent antibodies - in such a short time? We address this question using a microscopic, protein-level, sequence-based model of humoral immune response with explicitly defined interactions between Immunoglobulins, host and pathogen proteins.
arxiv
The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region. [PDF]
, 1991 A family of chimeric immunoglobulins (Igs) bearing the murine variable region directed against the hapten dansyl linked to human IgG1, -2, -3, and -4 has been characterized with respect to binding to the human high affinity Fc gamma receptor, Fc gamma RI.
Canfield, SM, Morrison, SL
core
Microbial Cell Factories, 2014 BackgroundIn recent years the generation of antibodies by recombinant methods, such as phage display technology, has increased the speed by which antibodies can be obtained.
M. Jørgensen +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan +8 more
wiley +1 more source
VH-RELATED IDIOTOPES DETECTED BY SITE-DIRECTED MUTAGENESIS [PDF]
, 1992 The function of the CD4 cell surface protein as coreceptor on T helper lymphocytes and as receptor for HIV makes this glycoprotein a prime target for an immune intervention with mAb.
Cheng, Y. H. +4 more
core +1 more source
Journal of Biological Chemistry, 2014 Background: Endoglycosidase S (EndoS) is an immune evasion factor from Streptococcus pyogenes that impedes IgG effector functions by deglycosylation. Results: Analysis of fragments of enzyme and substrate identify components of each that contribute to ...
E. Dixon +13 more
semanticscholar +1 more source
Advanced Science, EarlyView.Reprogramming the tumor immune microenvironment is crucial for transforming immune “cold” tumors into “hot” inflammatory tumors. The investigation reveals that the combination of ICAM‐1‐Dxd with B7‐H3‐CD3 bispecific antibodies not only demonstrates significant inhibitory effects on tumor growth and metastasis but also plays a vital role in ...
Shoubing Zhou +9 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Manning free counterions fraction for a rod-like polyion - short DNA fragments in very low salt [PDF]
arXiv, 2010 We quantified the Manning free (uncondensed) counterions fraction $\theta$ for dilute solutions of rod-like polyions - 150bp DNA fragments, in very low salt $<0.05$mM. Conductivity measurements of aqueous DNA solutions in the concentration range $0.015\leq c \leq 8$~mM (bp) were complemented by fluorescence correlation spectroscopy (FCS) measurements ...
arxiv