Results 141 to 150 of about 22,044 (247)

Acute splenomegaly, haemolysis, and thrombocytopenia following luspatercept initiation in a patient with transfusion-dependent thalassaemia: A case report. [PDF]

Br J Haematol
Zaidel B, Garland S, Merkeley H.
europepmc   +1 more source

Enhancement of t lymphocyte functions by Fc fragments of immunoglobulins. I. Augmentation of allogeneic mixed lymphocyte culture reactions requires I-A- or I-B-subregion differences between effector and stimulator cell populations [PDF]

, 1981
Morgan El, ML Thoman, W O Weigle
openalex   +1 more source

Bioorthogonal Reaction of o‐Quinone with Furan‐2(3H)‐One for Site‐Selective Tyrosine Conjugation and Construction of Bispecific Antibody Complexes

Advanced Science, Volume 12, Issue 22, June 12, 2025.
A site‐selective, efficient, and mild tyrosine conjugation via tyrosinase oxidation and nucleophilic addition, allowing for site‐selective functionalization of peptides, recombinant proteins, and IgGs. Site‐selective mono‐functionalization of IgGs at Y296 enables the construction of immunoliposomes.
Hongfei Chen, Zhiyi Xu, Yishu Bao, Farshad Shiri, Dingdong Yuan, Yuke Hu, Biquan Li, Bin Zeng, Xiaojing Li, Hao Kong, Zikang Wang, Wilson Chun‐Yu Lau, Zhenyang Lin, Jiang Xia   +13 more
wiley   +1 more source

IgG Biomarkers in Multiple Sclerosis: Deciphering Their Puzzling Protein A Connection. [PDF]

Biomolecules
Apeltsin L, Yu X.
europepmc   +1 more source

Equilibrium and pre-equilibrium fluorescence spectroscopic studies of the binding of a single-immunoglobulin-binding domain derived from protein G to the Fc fragment from human IgG1 [PDF]

, 1995
KAREN N. WALKER, Stephen Bottomley, Andrew G. Popplewell, Brian J. Sutton, Michael G. Gore   +4 more
openalex   +1 more source

Precision‐Guided Stealth Missiles in Biomedicine: Biological Carrier‐Mediated Nanomedicine Hitchhiking Strategy

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Diagram illustrating the binding methods of NPs and biological barriers. The biological carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS) utilizes two distinct techniques: the surface‐based “Backpack” method, which relies on ligand‐receptor binding, covalent conjugation, and non‐covalent binding, and the encapsulated “Trojan horse” approach,
Yuyan Zhou, Xinyue Wang, Deyu Zhang, Hanxiao Cui, Xiaorong Tian, Wei Du, Zhenghui Yang, Dongling Wan, Zhiwei Qiu, Chao Liu, Zhicheng Yang, Lizhihong Zhang, Qiusheng Yang, Xuefeng Xu, Wenhao Li, Dong Wang, Haojie Huang, Wencheng Wu   +17 more
wiley   +1 more source

Current status and future prospects of cancer-derived immunoglobulins in pancreatic cancer. [PDF]

J Cancer
Ma R, Zhang F, Ma Y, Liu W, Liu G, Chen Y, Zhang J, Yang Y, Tian X.   +8 more
europepmc   +1 more source

Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders.
Mathias Sauer, Bárbara Fernandes Gomes, Parasto Shahrouki, Juan Lantero‐Rodriguez, Laia Montoliu‐Gaya, Elena Camporesi, Olivia Belbin, Daniel Alcolea, Ashish Kumar, Mitu Sharma, Sangeeta Singh, Gunnar Brinkmalm, Johan Gobom, María Carmona‐Iragui, Michael Schöll, Shorena Janelidze, Gagan Deep, Kaj Blennow, Henrik Zetterberg, Ann Brinkmalm, Alberto Lleó, Juan Fortea, Oskar Hansson, Nicholas J. Ashton, Johanna Nilsson   +24 more
wiley   +1 more source

Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation. [PDF]

Commun Biol
Trabjerg E, Nilsen J, Tollefsrud Gjølberg T, Andersen JT, Leitner A, Rand KD.   +5 more
europepmc   +1 more source

Rational Design of Single‐Domain Antibodies Targeting the Central Nervous System Neurite Outgrowth Inhibitor Nogo‐A

Applied Research, Volume 4, Issue 3, June 2025.
The development of a nanobody for Nogo‐A, a potent neurite outgrowth inhibitor crucial in multiple sclerosis, is reported using a rational design approach. The nanobody targets the Nogo‐A ectodomain at the S1PR2 receptor‐binding region with submicromolar KD.
Vaidehi Roy Chowdhury, Alexander Röntgen, Matthew Greenig, Yanira Méndez Gómez, Sebastian P. Spiegel, Magdalena Nowinska, Aubin Ramon, Pietro Sormanni, Andrew Chan, Michele Vendruscolo   +9 more
wiley   +1 more source