Results 151 to 160 of about 90,091 (319)
CROSSING OVER BETWEEN GENES IN THE IMMUNOGLOBULIN HEAVY CHAIN LINKAGE GROUP OF THE MOUSE [PDF]
, 1969 Immunoglobulin heavy chain genes were found in wild mice (Mus musculus) that could best be explained as recombinants of immunoglobulin genotypes. In wild mice from Kitty Hawk, N.
Lieberman, Rose, Potter, Michael
core +2 more sources
Recent Advances in Enhancing the Sensitivity of Biosensors Based on Field Effect Transistors
Advanced Electronic Materials, EarlyView.This paper discusses the methods to enhancing the detection sensitivity of biosensors in three aspects: overcoming the influence of Debye shielding effects, promoting the binding efficiency of analytes and transistor surface, and improving the structures of device.
Yuying Zhou +8 more
wiley +1 more source
Attractors in residual interactions explain the differentially-conserved stability of Immunoglobulins [PDF]
arXiv, 2014 Proteins belonging to immunoglobulin superfamily(IgSF) show remarkably conserved nature both in their folded structure and in their folding process, but they neither originate from very similar sequences nor demonstrate functional conservation. Treating proteins as fractal objects, without studying spatial conservation in positioning of particular ...
arxiv
Penalized model-based clustering of fMRI data [PDF]
arXiv, 2020 Functional magnetic resonance imaging (fMRI) data have become increasingly available and are useful for describing functional connectivity (FC), the relatedness of neuronal activity in regions of the brain. This FC of the brain provides insight into certain neurodegenerative diseases and psychiatric disorders, and thus is of clinical importance.
arxiv
Application of humanized mice in the safety experiments of antibody drugs
Animal Models and Experimental Medicine, EarlyView.The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun +9 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Our objective was to evaluate the efficacy and safety of subcutaneous (SC) abatacept and standard of care (SOC) for the treatment of idiopathic inflammatory myopathy (IIM) over 52 weeks. Methods In this randomized, double‐blind, placebo‐controlled phase III trial, patients with treatment‐refractory IIM received SC abatacept (at 125 mg weekly)
Rohit Aggarwal +5 more
wiley +1 more source
The Super-FRS GEM-TPC prototype development - TDR [PDF]
arXiv, 2016 This document contains the pre-design of the beam diagnostics components Tracking Detectors for the Super-FRS. A GEM-TPC detector has been suggested as suitable tracking detector for the ion/fragment beams produced at the in-flight separator Super-FRS under construction at the FAIR facility.
arxiv
Structural characterisation of human immunoglobulin G Fc fragment and its interaction with heparin [PDF]
, 2020 Human immunoglobulin (Ig) G is the most commonly found class of antibody in the human body and is involved in pathogen recognition as a part of the adaptive and innate immune response. Recognition occurs through the fragment antibody binding (FAB) region
Earps, Henry Frederick
core +1 more source
Escherichia coli in the production of biopharmaceuticals
Biotechnology and Applied Biochemistry, EarlyView.Abstract Escherichia coli has shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, in E. coli and its use in treating diabetes. After insulin, many biopharmaceuticals produced from E. coli have been approved by the
İbrahim İncir, Özlem Kaplan
wiley +1 more source
FC-Datalog as a Framework for Efficient String Querying [PDF]
arXivCore spanners are a class of document spanners that capture the core functionality of IBM's AQL. FC is a logic on strings built around word equations that when extended with constraints for regular languages can be seen as a logic for core spanners.
arxiv