Results 161 to 170 of about 76,339 (318)

The fc fragment of IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement‐dependent cytotoxicity

The FEBS Journal, EarlyView.
Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Andrea J. Pinto, Anne Chouquet, Isabelle Bally, Véronique Rossi, Nicole M. Thielens, Chantal Dumestre‐Pérard, Renate Kunert, Christine Gaboriaud, Wai Li Ling, Jean‐Baptiste Reiser   +9 more
wiley   +1 more source

Different Fc scaffolds enhance the breadth of <i>in vitro</i> neutralization of the same Fab against different Rotavirus strains. [PDF]

Front Immunol
Miranda-Echagüe MR, Vezzani G, Morandi E, Della Peruta M, Scordio M, Reyes TAC, Oldrini D, Iturriza-Gómara M, Loomis RJ, Rossi O.   +9 more
europepmc   +1 more source

Elementary immunology [PDF]

, 2017
Gogolák, Péter, Koncz, Gábor
core  

Monitoring of Nonacog Beta Pegol: One‐Stage Clotting Assay With Kaolin Reagent as a Practical Alternative to Chromogenic Methods

Haemophilia, EarlyView.
ABSTRACT Introduction Accurate monitoring of nonacog beta pegol (N9‐GP) is essential to ensure appropriate treatment and to avoid under‐ or overdosing, which may result in clinical complications. The product's extended half‐life, achieved through molecular modification, poses challenges for activity measurement, particularly when using a one‐stage ...
Marie Prudková, Petr Smejkal, Dagmar Chytrá, Jiřina Zavřelová, Gabriela Romanová, Miroslav Penka, Alena Buliková   +6 more
wiley   +1 more source

Biological Effects of F(ab')2 Fragments Generated by Imlifidase From Anti-HLA IgG Antibodies From Transplant Patients. [PDF]

HLA
Devriese M, Carelli I, Giraldo L, Pin A, Groshaeny N, Silva SD, Bockermann R, Taupin JL.   +7 more
europepmc   +1 more source

First successful protocol for desensitization to eptinezumab

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background Eptinezumab is an anti‐calcitonin gene‐related peptide monoclonal antibody used for migraine prevention. During clinical trials, hypersensitivity to eptinezumab was described without a clear underlying mechanism. To determine if the reaction was immunoglobulin E–mediated, the team of Nice University Hospital (Nice, France) performed
Benoit Gerard, Hubert Praudel, Michel Lanteri‐Minet, Elise Van Obberghen, Fanny Rocher‐Moreau, Johanna Rousset, Ulysse Jacquier, Sylvie Leroy, Margot Delin   +8 more
wiley   +1 more source

The role of immunoglobulin E in non-atopic disorders. [PDF]

Front Immunol
Thaçi K, Gyorgypal A, Anthony RM, Conroy ME.   +3 more
europepmc   +1 more source

The Dual Immunoregulatory Role of CREB3L1 Underlying Latent and Severe Tuberculosis Clinical Manifestation

Immunology, EarlyView.
RNA‐seq of lungs and livers from Mycobacterium tuberculosis‐infected mice with distinct disease outcomes revealed organ‐specific responses driven by differences in immune activity and bacterial burden. Meta‐analysis identified orthologous genes shared with human latent TB and mouse liver, with Creb3l1, Myo7b, Cyyr1 and Cbs differentially expressed and ...
Felipe T. Lima, Ricardo C. Castro, Francisco R. Javier, Caroline Fontanari, Valdes R. Bollela, Rogerio S. Rosada, Célio L. Silva, Lúcia H. Faccioli, Luiz G. Gardinassi, Fabiani G. Frantz   +9 more
wiley   +1 more source

Construction of an Immunosensor Based on the Affinity DNA Functional Ligands to the Fc Segment of IgG Antibody. [PDF]

Biosensors (Basel)
Yang Q, Liu Z, Xu X, Zhao Z, Fan Z, Du B, Xu J, Xu J, Wang J, Liu B, Mu X, Tong Z.   +11 more
europepmc   +1 more source

Single‐molecule validation and optimised protocols for the use of secondary nanobodies in multiplexed immunoassays

Journal of Microscopy, EarlyView.
Abstract Recently developed secondary nanobodies or single‐domain antibodies present a powerful tool for immunodetection. Unlike traditional antibodies, their monovalence enables pre‐association with primary antibodies prior to sample staining, presenting a straightforward affinity‐based antibody labelling solution.
Rebecca Saleeb, Judi O'Shaughnessy, Ryan Ferguson, Candace T. Adams, Mathew H. Horrocks   +4 more
wiley   +1 more source