Results 191 to 200 of about 51,720 (301)

Impact of platelet transfusions on plasma proteomes in controlled endotoxemia and in hemato‐oncological patients

open access: yesTransfusion, EarlyView.
Abstract Background Inflammation is a hallmark of patients that receive platelet transfusions, including critically ill and hemato‐oncological patients. Platelet transfusions have been suggested to exacerbate inflammatory conditions, resulting in transfusion‐related complications.
Eva R. Smit   +11 more
wiley   +1 more source

Integrating Biochemical and Computational Approaches Reveal Structural Insights in Trastuzumab scFv-Fc Antibody Engineering. [PDF]

open access: yesBiomolecules
Bednova O   +9 more
europepmc   +1 more source

Effects of a combined energy restriction and vigorous‐intensity exercise intervention on the human gut microbiome: A randomised controlled trial

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The human gut microbiome remains stable in the face of an intensive energy restriction and vigorous‐intensity exercise intervention that improved body composition and metabolic health in people with overweight/obesity. Thus, early metabolic changes with weight loss in humans are unlikely to be mediated by changes to the gut ...
Russell G. Davies   +15 more
wiley   +1 more source

Flavonoids in Rosa roxburghii Tratt Fermentation Broth Ameliorate Obesity via DNMT3a/SIRT1‐Mediated Epigenetic Modulation

open access: yesFood Science &Nutrition, Volume 13, Issue 9, September 2025.
Rosa roxburghii Tratt fermentation broth alleviates obesity via DNMT3a/SIRT1 axis. RRTFB reduces fat mass, and inflammation while enhancing antioxidant activity. Flavonoids in RRTFB are the primary bioactive components. ABSTRACT Obesity‐related complications are often driven by chronic inflammation and oxidative stress, exacerbated by aberrant DNA ...
Mi Liu   +9 more
wiley   +1 more source

Spatiotemporal Dynamics of Central Nervous System Diseases: Advancing Translational Neuropathology via Single‐Cell and Spatial Multiomics

open access: yesMedComm, Volume 6, Issue 9, September 2025.
Central nervous system (CNS) diseases are driven by spatiotemporally dynamic molecular networks. Single‐cell and spatial multiomics technologies dissect cellular heterogeneity, microenvironmental remodeling, and intercellular crosstalk. Integration of transcriptomic, epigenomic, proteomic, and metabolomic layers reveals disease‐associated regulatory ...
Mingkai Xia   +4 more
wiley   +1 more source

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