Results 221 to 230 of about 76,339 (318)

IdeZ protease does not prevent convertase stabilization by C3 nephritic factors in C3 glomerulopathy. [PDF]

Nephrol Dial Transplant
Stevens KH, Baas LM, van de Kar NCAJ, van den Heuvel LPWJ, Michels MAHM.   +4 more
europepmc   +1 more source

Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements

European Journal of Immunology, Volume 56, Issue 2, February 2026.
A deeper understanding of the natural killer cell gene expression regulation driving NK cell maturation and cytotoxicity could provide critical insights into optimizing NK therapies. Our findings reveal novel enhancers governing NK cell genes for NCAM1/CD56 and cis‐regulation for KIR receptors and clarify existing models of NK cell cis‐accessibility ...
Mariam A. Salem, Aditi Varkey, Matthew D. Estrada, Kruthika Sharma, Caprice D. Eisele, Nitin Chakravarti, Dean A. Lee, Aharon G. Freud, Bethany L. Mundy‐Bosse, Patrick L. Collins   +9 more
wiley   +1 more source

Structural and functional characterization of IdeC, a novel IgG-specific protease of <i>Streptococcus canis</i>. [PDF]

Infect Immun
Walsh S, Lapschies A-M, Miguel-Ruano V, Batuecas MT, Acebrón-Ávalos I, Kohler TP, Hammerschmidt S, Eichhorn I, Hermoso JA, Fulde M.   +9 more
europepmc   +1 more source

Monoclonal Antibodies: Historical Perspective and Current Trends in Biological Drug Development. [PDF]

Int J Mol Sci
Madej B, Tomaszewski F, Szmajda-Krygier D, Świechowski R, Jeleń A, Mirowski M.   +5 more
europepmc   +1 more source

Iterative Modeling via Structural Diffusion (IMSD): Exploring Fold‐Switching Pathways in Metamorphic Proteins Using AlphaFold2‐Based Generative Diffusion Model UFConf

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 633-648, February 2026.
ABSTRACT Metamorphic proteins (MPs) can fold into two or more distinct spatial structures. Increasing interest in MPs has spurred the search for computational tools to predict proteins fold‐switching potential and model their refolding pathways. Here we address this problem by using the recently reported generative diffusion predictor UFConf, based on ...
Dmitrii A. Luzik, Nikolai R. Skrynnikov
wiley   +1 more source

Diffusion, search and attack motions of antibodies. [PDF]

Commun Biol
Biehl R, Kruteva M, Czakkel O, Hoffmann I, Richter D, Stadler AM.   +5 more
europepmc   +1 more source

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings, Serbülent Ünsal, Mathieu Rappas, Matthew Barnes, Maria Waldhoer, Ben Holland, Martin Culka   +6 more
wiley   +1 more source

Design and Synthesis of MBP-Fc-Bifunctional Peptide Inhibitor to Improve <i>In Vivo</i> Half-Life and Efficacy. [PDF]

Mol Pharm
Mahadik R, Schwinghamer K, Villela-Nava AL, Siahaan TJ, Tolbert T.   +4 more
europepmc   +1 more source

Cryptofauna Associated With the Epilithic Algal Matrix on Subtropical Brazilian Reefs

Austral Ecology, Volume 51, Issue 2, February 2026.
ABSTRACT The epilithic algal matrix (EAM) plays a significant role in the benthic cover of reefs worldwide. In Brazil, the EAM accounts for a substantial proportion of the benthos, and its associated fauna contributes to the majority of the reef's metazoan biodiversity and is an important link into the trophic chain, connecting the production performed
Gabriel Soares Figueiredo Barros, Quenia Nascimento Lyrio, Cesar Augusto Marcelino Mendes Cordeiro, Carlos Eduardo Leite Ferreira   +3 more
wiley   +1 more source

Integrating Protein Resistance and Bioconjugation in P(OEGMA-<i>co</i>-MAA) Brushes for Biosensing and Cell Culture: ToF-SIMS Profiling and Antibody Characterization. [PDF]

ACS Appl Mater Interfaces
Gajos K, Lishchynskyi O, Da̧bczyński P, Tymetska S, Bodek Ł, Shymborska Y, Janiszewska N, Stetsyshyn Y, Budkowski A.   +8 more
europepmc   +1 more source