Results 231 to 240 of about 22,044 (247)

Denaturation by Guanidine Hydrochloride of the Fc(t) and pFc' Fragments of Human Immunoglobulin G1

The Journal of Biochemistry, 1982
The denaturation and renaturation by guanidine hydrochloride of Fc(t) fragment whose interchain disulfide bonds are reduced and alkylated (R.A.Fc(t)) and pFc' fragment of a human myeloma protein (IgGl, kappa) were studied using tryptophyl fluorescence. R.A.Fc(t) was found to consist of a slow-unfolding region and a rapid-unfolding region.
Akinori Sumi, Kozo Hamaguchi
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Investigation of the Cooperative Structure of Fc Fragments from Myeloma Immunoglobulin G

Biochemistry, 1998
The cooperative structure of Fc fragments prepared from myeloma human IgG1 was studied using scanning microcalorimetry and fluorescence at pH 4.2-8.0. It was shown that the first to be melted are CH2 domains whose interaction with each other is rather weak, while that with CH3 domains is strong.
V. M. Tischenko, Vladimir P. Zav'yalov, Vyacheslav M. Abramov   +2 more
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Effective treatment of experimental autoimmune neuritis with Fc fragment of human immunoglobulin

Journal of Neuroimmunology, 2007
IV immunoglobulin (IVIg) and its Fc fragment proved effective in preventing further progression of experimental autoimmune neuritis (EAN) in the rat induced by whole bovine peripheral nerve myelin and shortening disease duration. This effectiveness was associated with significant differences in electrophysiological parameters including less ...
Min-Xia Wang, Min-Xia Wang, Judith M. Spies, Judith M. Spies, John D. Pollard, John D. Pollard, Hsin Hsin Lin   +6 more
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Ultrastructure of the Fc fragment of human immunonoglobulin G

Immunochemistry, 1971
Abstract Crystals of the plasmin Fc fragment of human immunoglobulin G have been examined in the electron microscope at various stages during dissociation and recrystallization. Two characteristic shapes are recognized in the micrographs. One is a double, concentric annulus in which the outer annulus is seen to consist of 12 masses disposed radially ...
L. Pinteric, R H Painter, G. E. Connell
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Genetic (Gm) Antigens associated with Subfragments from the Fc Fragment of Human Immunoglobulin G [PDF]

Nature, 1969
THE specific (γ) polypeptide chain of immunoglobulin G (IgG, ref. 1) molecules carries several genetic markers (Gm antigens)2,3 which can be detected by serological techniques. Each of the markers is associated with one of three subclasses of γ chain, called γ1, γ2 or γ3 chains4.
M. W. Turner, Hans Bennich, L. Mårtensson, J. B. Natvig   +3 more
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Human Immunoglobulin A: Production of an Fc Fragment by an Enteric Microbial Proteolytic Enzyme

The Journal of Immunology, 1973
Summary An Fc fragment has been prepared in good yield by proteolytic cleavage of human secretory and serum myeloma IgA with an enzyme recovered from the human gastrointestinal tract. The naturally occurring enzyme is of microbial origin and its activity is metal dependent.
S K, Mehta, A G, Plaut, N J, Calvanico, T B, Tomasi   +3 more
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An improved protocol for large scale production of high purity ‘Fc’ fragment of human immunoglobulin G (IgG-Fc)

Journal of Chromatography B, 2020
We describe a simplified approach for purification and characterization of human 'IgG-Fc' fragment used widely as immunochemical tool and for therapeutic purposes. The 'Fc' fragment was purified from human IgG in a 3-stage column chromatography. The purified 'Fc' fragment appeared as a dimer glycoprotein with an apparent molecular mass of 52,981 Dalton
Unmesh Angre, Sanjeev Lala, Siddharth B. Daftary, Babasaheb U. Tandale, Shamkant B. Badgujar, Jatin B. Tandale, Vinod P. Gaur   +6 more
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Expression of Fc Fragment Receptors of Immunoglobulin G (Fc?Rs) in Rat Hepatic Stellate Cells

Digestive Diseases and Sciences, 2005
Hepatic stellate cells (HSCs) are now considered the major cell type in the liver mediating the development of liver fibrosis. Recently it was demonstrated that HSCs express membrane proteins involved in antigen presentation. We further evaluate immunological properties of HSCs by examining the expression and function of the Fc fragment of ...
Hong Shen, Manna Zhang, Kelly Kaita, Yuewen Gong, Julia D. Rempel, Gerald Y. Minuk   +5 more
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Chemical and immunological characterization of the electrophoretic components of the Fc fragment of human immunoglobulin G

Immunochemistry, 1972
Abstract The major electrophoretic components of Fc prepared by plasmin digestion of human IgG ( γ 1 subclass) have been isolated and their physical, chemical and biological properties examined. The individual components showed the same amino acid composition, the same amino terminal residue, threonine, and were shown to have the same sedimentation
J.Oduro Minta, R H Painter
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Production of an Fc Fragment from Human Immunoglobulin a by an IgA-Specific Bacterial Protease

1974
Enzymatic proteolysis of human immunoglobulin A yields Fabα fragments but the Fcα is degraded to small peptides. The unavailability of Fcα has hampered to some extent certain studies of IgA, e.g., its primary structure and the attachment site of secretory component and J chain.
Andrew G. Plaut, Andrew G. Plaut, Thomas B. Tomasi, Thomas B. Tomasi, Robert J. Genco, Robert J. Genco   +5 more
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