Results 231 to 240 of about 76,339 (318)

Low immunogenicity of insulin efsitora alfa in participants with type 1 and type 2 diabetes mellitus

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1350-1358, February 2026.
Abstract Aims To evaluate treatment‐emergent antidrug antibodies (TE ADA) in once‐weekly basal insulin efsitora‐treated participants with type 1 and type 2 diabetes mellitus (T1DM and T2DM) from 5 phase 3 clinical trials and their potential impact on pharmacokinetics, efficacy and safety.
Yun Wang, Sihe Wang, Wei Wang, Xiaoqi Li, Jennifer Leohr, Vitoria Pires, Michelle L. Katz, Christopher J. Child, Robert J. Konrad   +8 more
wiley   +1 more source

Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
This review presents the latest advances in the development of ruthenium complexes within the field of protein science, highlighting their potential applications in biomedical and bioanalytical fields. Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years,
Liyan Zhang, Yun Chen, Sylvestre Bonnet
wiley   +2 more sources

Exploring glycoform-dependent dynamic modulations in human immunoglobulin G via computational and experimental approaches. [PDF]

Proc Natl Acad Sci U S A
Yanaka S, Sakae Y, Miyanoiri Y, Yamaguchi T, Isono Y, Kondo S, Iwasaki M, Onitsuka M, Yagi H, Kato K.   +9 more
europepmc   +1 more source

T‐Cell–Redirecting Immunotherapies in Relapsed/Refractory Mantle Cell Lymphoma: Current Evidence, Sequencing, and Future Directions

European Journal of Haematology, Volume 116, Issue 2, Page 129-141, February 2026.
ABSTRACT Relapsed/refractory (R/R) mantle cell lymphoma (MCL) remains a therapeutic challenge, particularly in patients with high‐risk features or prior exposure to Bruton's tyrosine kinase inhibitors (BTKis). The advent of T‐cell–redirecting immunotherapies, including chimeric antigen receptor T‐cell (CAR‐T) therapy and bispecific antibodies (BsAbs ...
Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Massimo Gentile   +10 more
wiley   +1 more source

Blood-Nerve Barrier Breakdown Induced by Immunoglobulin G in Typical and Multifocal Chronic Inflammatory Demyelinating Polyneuropathy and Multifocal Motor Neuropathy. [PDF]

Int J Mol Sci
Shimizu F, Sato R, Mizukami Y, Watanabe K, Maeda T, Kanda T, Matsui N, Misawa S, Izumi Y, Kuwabara S, Nakamori M.   +10 more
europepmc   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

RAPPID-M: A Mix-and-Measure Bioluminescent Sandwich Immunoassay Based on Generic Antibody-Binding Protein M. [PDF]

ACS Sens
Swietlikowska A, van Aalen E, Bossink M, van Weesep L, Merkx M.   +4 more
europepmc   +1 more source

Temporal and Sex-Dependent <i>N</i>-Glycosylation Dynamics in Rat Serum. [PDF]

Int J Mol Sci
Yagi H, Kondo S, Murakami R, Yogo R, Yanaka S, Umezawa F, Yagi-Utsumi M, Fujita A, Okina M, Hashimoto Y, Hotta Y, Kato Y, Nakajima K, Furukawa JI, Kato K.   +14 more
europepmc   +1 more source

Preparation of ESAT6-Fc Fusion Protein and Its Therapeutic Efficacy and Immune Mechanisms in Allergic Asthma Mice via Intranasal Immunization. [PDF]

Molecules
Wang J, Hai M, Yang Y, Wang T, Zhang W, Ma R, Sun M, Qin Y, Yang Y, Dong Z, Yang M, Wan Q.   +11 more
europepmc   +1 more source

Overcoming Synthetic Challenges and Evaluating in Vivo Efficacy of the MOG-Fc-Bifunctional Peptide Inhibitor for EAE in Mice. [PDF]

Bioconjug Chem
Mahadik R, Villela-Nava AL, Xin L, Siahaan TJ, Tolbert T.   +4 more
europepmc   +1 more source