Results 151 to 160 of about 218 (190)

Differentiation of Cytotoxic CD8+ T Cell Subsets Under Tumor Progression: Can CD69 Be a New Therapeutic Target?

Cancer Science, EarlyView.
This review summarizes the current understanding of cytotoxic CD8+ T cell subset differentiation under tumor progression and highlights the crucial role of chronic CD8+ T cell responses in anti‐tumor immunity. CD69 is an important regulator of chronic CD8+ T cell response that contributes to the induction of the Tox gene via calcineurin/NFAT signaling.
Ryo Koyama‐Nasu, Yangsong Wang, Hinata Miyano, Motoko Y. Kimura   +3 more
wiley   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

Cell Proliferation, EarlyView.
ECH protects senescent oocytes by stabilising the cytoskeleton, restoring mitochondrial function, reducing oxidative stress and maintaining cellular homeostasis, primarily through the GJA1/SIRT1 signalling pathway. ABSTRACT As maternal age increases, the decline in oocyte quality emerges as a critical factor contributing to reduced reproductive ...
Liuqing Yang, Xinle Lai, Fangxuan Lin, Nan Shi, Xinya Xu, Heng Wang, Xiaotian Li, Dan Shen, Haimo Qian, Xin Jin, Jiayi Chen, Zhongwei Huang, Xing Duan, Qin Zhang   +13 more
wiley   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Obesity‐related glomerulopathy: How it happens and future perspectives

Diabetic Medicine, EarlyView.
Abstract Obesity‐related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% of individuals can be affected by ORG, irrespective of the status of glomerular filtration rate and albuminuria.
Jian‐Wen Samuel Lee‐Boey, Jia‐Kai Tan, Zhan‐Foong Lim, Francesco Zaccardi, Kamlesh Khunti, Majid Ezzati, Edward W. Gregg, Lee‐Ling Lim   +7 more
wiley   +1 more source

CLLAF SCORE—A New Risk Score for Predicting Atrial Fibrillation in Treatment‐Naive CLL Patients Initiating First‐ and Second‐Generation BTK Inhibitor Therapy

European Journal of Haematology, EarlyView.
ABSTRACT Background One of the limiting toxicities of BTKi is the development of atrial fibrillation (AF), with an incidence of 3%–16%. Aim This study aimed to identify patients with chronic lymphocytic leukemia (CLL) starting both first‐ and second‐generation BTKis who are at high risk of developing AF using a machine learning approach.
Tamar Tadmor, Guy Melamed, Hilel Alapi, Lior Rokach   +3 more
wiley   +1 more source

Metabolomic and proteomic stratification of equine osteoarthritis

Equine Veterinary Journal, EarlyView.
Abstract Background Equine osteoarthritis (OA) is predominantly diagnosed through clinical examination and radiography, leading to detection only after significant joint pathology. The pathogenesis of OA remains unclear and while many medications modify the disease's inflammatory components, no curative or reversal treatments exist.
James R. Anderson, Marie M. Phelan, Eva Caamaño‐Gutiérrez, Peter D. Clegg, Luis M. Rubio‐Martinez, Mandy J. Peffers   +5 more
wiley   +1 more source

Transfer RNA and small molecule therapeutics for aminoacyl‐tRNA synthetase diseases

The FEBS Journal, EarlyView.
Aminoacyl‐tRNA synthetases catalyze the ligation of a specific amino acid to a cognate tRNA—a reaction that lays the foundations for deciphering the genetic code. Pathogenic alleles in these synthetases can lead to dominant or recessive disorders, for which little or no disease‐specific treatments exist.
Tristan N. Samuels, Fanqi Wu, Maria Mahmood, Wajd A. Abuzaid, Nancy Sun, Angelica Moresco, Victoria M. Siu, Patrick O'Donoghue, Ilka U. Heinemann   +8 more
wiley   +1 more source

A new era in myeloma: the advent of chimeric antigen receptor‐T (CAR‐T) cells and bispecific antibodies

Internal Medicine Journal, EarlyView.
Abstract T‐cell re‐directional therapies, including chimeric antigen receptor (CAR)‐T cell and bispecific antibodies (BsA), have transformed the treatment landscape to benefit patients with multiple myeloma. A number of these novel therapies has been approved internationally, with CAR‐T therapy recently approved in Australia.
P. Joy Ho, Eric W. Li
wiley   +1 more source

Clustering Longitudinal Data: A Review of Methods and Software Packages

International Statistical Review, EarlyView.
Summary Clustering of longitudinal data is becoming increasingly popular in many fields such as social sciences, business, environmental science, medicine and healthcare. However, it is often challenging due to the complex nature of the data, such as dependencies between observations collected over time, missingness, sparsity and non‐linearity, making ...
Zihang Lu
wiley   +1 more source