Results 81 to 90 of about 16,771 (215)

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Cell-type-specific and regulated expression of a human gamma 1 heavy-chain immunoglobulin gene in transgenic mice.

, 1986
K Yamamura, Akira Kudō, Takao Ebihara, Kouzin Kamino, Koji Araki, Y Kumahara, Takeshi Watanabe   +6 more
openalex   +2 more sources

Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression. [PDF]

, 1995
Ronit Aloni-Grinstein, Dov Schwartz, Varda Rotter   +2 more
openalex   +1 more source

Immunological Profiling suggests an Association between Treg dysfunction and Pain in Knee Osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Background Pain is the hallmark symptom of osteoarthritis (OA) and its biological drivers remain poorly understood. While the role of innate immunity in OA has been extensively studied, the involvement of adaptive immunity, in particular regulatory T cells (Tregs), is not well understood. Methods We performed omics profiling of peripheral blood from 46
Marie Binvignat, Johanna Dubois, Maria Marco Salvador, Paul Stys, Fabien Pitoiset, Alexandra Roux, Michèle Sastre, Signe Hassler, Roberta Lorenzon, Claire Ribet, Vanessa Mhanna, Hélène Vantomme, Leslie Adda, Pierre Barennes, Nicolas Coatnoan, Kenz Le Gouge, Caroline Aheng, Alice Courties, Lise Minssen, Atul J. Butte, Adrien Six, Michelle Rosenzwajg, Nicolas Tchitchek, Francis Berenbaum, David Klatzmann, Encarnita Mariotti‐Ferrandiz, Jérémie Sellam   +26 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism.

, 1981
Masanori Obata, Tohru Kataoka, S. Nakai, Hideo Yamagishi, Naoki Takahashi, Yuriko Yamawaki‐Kataoka, T Nikaido, Akira Shimizu, Tasuku Honjo   +8 more
openalex   +2 more sources

Proteomic analysis identified salivary immunoglobulin gamma-3 chain C as a potential biomarker for systemic lupus erythematosus [PDF]

, 2020
Ju-Yang Jung, Jinyoung Nam, Keun-Sil Ryu, Joo‐Ho Shin, Sung Min Lee, Wook-Young Baek, Hyoun‐Ah Kim, Chang‐Hee Suh   +7 more
openalex   +1 more source

Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK pathways

Arthritis &Rheumatology, Accepted Article.
Introduction Rheumatoid sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a frequent comorbidity in rheumatoid arthritis (RA), linked to prolonged, severe systemic inflammation. Purinergic signaling (adenosine, AMP, and ATP) plays a crucial role in inflammation, myogenesis, and muscle hypertrophy.
Miguel Marco‐Bonilla, Maria Fresnadillo, Irene Sanchez‐Platero, Macarena de la Riva‐Bueno, Fernando Huete‐Toral, Gonzalo Carracedo, Carmen Conde, Yolanda Benitez, Pablo Minguez, Sandra Carolina Cifuentes, Joaquin Rams, Gabriel Herrero‐Beaumont, Raquel Largo, Aránzazu Mediero   +13 more
wiley   +1 more source

Cloning immunoglobulin gamma 2b chain gene of mouse: characterization and partial sequence determination.

, 1979
Takao Kataoka, Yuriko Yamawaki‐Kataoka, Hideo Yamagishi, Tasuku Honjo   +3 more
openalex   +2 more sources