Results 111 to 120 of about 225,064 (376)

Immunoglobulin light chain amyloidosis: 2018 Update on diagnosis, prognosis, and treatment

American journal of hematology/oncology, 2018
Immunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy chain are deposited in tissues.
M. Gertz
semanticscholar   +1 more source

Adducin‐1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity

Advanced Science, EarlyView.
In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang, Jiahui Zou, Yaoming Jin, Chenjun Jiang, Shaoyu Tu, Tong Chen, Jinli Guo, Yanqing Cheng, Meilin Jin, Huanchun Chen, Hongbo Zhou   +10 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Acquired cutis laxa associated with light and heavy chain deposition disease

Indian Dermatology Online Journal, 2018
Acquired cutis laxa (ACL) is a rare connective tissue disorder characterized by pendulous and coarsely wrinkled skin. There have been few cases of its association to monoclonal immunoglobulin deposition disease (MIDD), which constitutes the light chain ...
Reena A Majithia, Leni George, Meera Thomas, N A Fouzia   +3 more
doaj   +1 more source

Purification and characterisation of immunoglobulins from the serum of a catfish, Clarias gariepinus (Burchell, 1822) [PDF]

, 2004
Attempts have been made to characterize and purify immunoglobulins from the serum of Clarias gariepinus, which has been immunized with bovine serum albumen. Initially, the proteins in the serum were chromatographed successively by affinity chromatography
Mastan, S.A., Pavez, N., Qureshi, T.A., Rashee, S., Rathore, G., Swaminathan, T.R.   +5 more
core  

An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy

Advanced Science, EarlyView.
This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma, Jie Wang, Min Jiang, Juanhua He, Fangyang Li, Dan Lu, Chao Su, Yan Chai, Wenjing Jin, Yu Chen, Catherine W.H. Zhang, Xiaopeng Ma, Hui Tan, George F. Gao, Shuguang Tan   +14 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Immunoglobulin heavy chain gene rearrangements in patients with Gaucher disease [PDF]

Journal of Medical Biochemistry, 2018
Background: Several studies support the evidence of increased incidence of hematological complications in Gaucher disease including monoclonal and polyclonal gammopathies and blood malignancies, especially multiple myeloma.
Rodić Predrag, Lakočević Milan, Pavlović Sonja, Karan-Đurašević Teodora, Kostić Tatjana, Suvajdžić-Vuković Nada, Šumarac Zorica, Petakov Milan, Janić Dragana   +8 more
doaj  

B cell receptor accessory molecule CD79α : characterisation and expression analysis in a cartilaginous fish, the spiny dogfish (Squalus acanthias) [PDF]

, 2013
Copyright © 2013.
Anderson, Bhargava, Bird, Bodine, Browne, Cambier, Campanella, Campbell, Campbell, Christopher J. Secombes, DeFranco, Dooley, Dooley, Dylke, Eason, Eckner, Engels, Fitzsimmons, Flajnik, Flajnik, Guselnikov, Ha, Hagman, Haire, Haman, Hardy, Heinemeyer, Helen Dooley, Hinds, Ito, Jang, Johnson, Jun Zou, Kabak, Kahsay, Kashiwamura, Larkin, Lee, Li, Luisiri, Lukin, Malecek, Mason, Minegishi, Miracle, Mount, Neuberger, Patterson, Petersen, Pfaffl, Pryjma, Rast, Ravi, Reddick, Reth, Reth, Reth, Roessler, Ronggai Li, Rumfelt, Sahoo, Sakaguchi, Salim, Sanchez, Sigrist, Sigvardsson, Smith, Steinke, Steve Bird, Tamura, Tiehui Wang, Travis, Volff, Walsh, Wang, Williams, Youn, Youn, Yu   +78 more
core   +2 more sources

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

Proceedings of the National Academy of Sciences of the United States of America, 1982
A chromosomal segment with a unique structure around the immunoglobulin heavy chain joining region (JH) has been molecularly cloned from an Abelson murine leukemia virus-transformed cell line.
F. Alt, D. Baltimore
semanticscholar   +1 more source