Results 181 to 190 of about 225,064 (376)

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

A case of heavy-chain deposition disease with good long-term renal survival and a literature review

BMC Nephrology
Background Monoclonal immunoglobulin deposition disease (MIDD) is characterized by the deposition of nonamyloid monoclonal immunoglobulin and its free fragment light chain and/or heavy chain in systemic tissues and organs, and the kidney is most ...
Xiaoqing Cai, Wenli Zou, Huaihuai Chen, Chaonian Xing, Xuguang Yu   +4 more
doaj   +1 more source

A hereditary immunoglobulin A abnormality: absence of light-heavy—chain assembly [PDF]

, 1971
Chaya Moroz, Jacob Amir, André de Vries
openalex   +1 more source

Complex sex-biased antibody responses: estrogen receptors bind estrogen response elements centered within immunoglobulin heavy chain gene enhancers

International Immunology, 2019
B. Jones, R. Sealy, R. Penkert, S. Surman, R. Maul, G. Neale, Beisi Xu, P. Gearhart, J. Hurwitz   +8 more
semanticscholar   +1 more source

Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47

Cancer Communications, EarlyView.
Abstract Background Only a few bladder cancer patients benefit from anti‐programmed cell death protein 1/programmed cell death ligand 1 immunotherapy. The cluster of differentiation 47 (CD47) plays an important role in tumor immune evasion. CD47 is a highly glycosylated protein, however, the mechanisms governing CD47 glycosylation and its potential ...
Jie Zhang, Chen Zhang, Ruichen Zang, Weiwu Chen, Yining Guo, Haofei Jiang, Jing Le, Kunyu Wang, Haobo Fan, Xudong Wang, Sisi Mo, Peng Gao, Wenhao Guo, Xinrong Jiang, Fengbin Gao, Junming Jiang, Juyan Zheng, Yuxing Chen, Yicheng Chen, Yanlan Yu, Guoqing Ding   +20 more
wiley   +1 more source

Data on the nucleotide composition of the first codons encoding the complementary determining region 3 (CDR3) in immunoglobulin heavy chains

Data in Brief, 2018
The highly variable complementary determining region 3 (CDR3) of antibodies is generated through recombination of immunoglobulin heavy chain variable (IGHV), diversity, and joining genes.
Linnea Thörnqvist, Mats Ohlin
doaj  

Retraction Note: 3'RR and 5'Eμ immunoglobulin heavy chain enhancers are independent engines of locus remodeling. [PDF]

Cell Mol Immunol, 2021
Ghazzaui N, Issaoui H, Boyer F, Martin OA, Saintamand A, Denizot Y.   +5 more
europepmc   +1 more source

Cloned pairs of variable region genes for immunoglobulin heavy chains isolated from a clone library of the entire mouse genome. [PDF]

, 1979
Darrell J. Kemp, Suzanne Cory, Jerry M. Adams   +2 more
openalex   +1 more source

Isolation of mRNA coding for immunoglobulin heavy chain [PDF]

Proceedings of the National Academy of Sciences, 1975
A. R. Williamson, Ronald H. Stevens
openaire   +3 more sources

Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele

Chronic Diseases and Translational Medicine, EarlyView.
Mechanism of action of monoclonal antibodies targeting Aβ in the treatment of AD. (A) Targets of various mAbs. (B) Mechanism of monoclonal antibody‐mediated clearance of Aβ. mAbs facilitate the clearance of Aβ by enhancing microglial‐mediated phagocytosis through the upregulation of TREM2 expression.
Valentinus Besin, Farizky Martriano Humardani, Fenny Lanawati Yudiarto, Paulus Anam Ong, Sulistyo Emantoko Dwi Putra, Ratih Asmana Ningrum   +5 more
wiley   +1 more source