Results 351 to 360 of about 225,064 (376)
Some of the next articles are maybe not open access.
T-cell idiotypes are linked to immunoglobulin heavy chain genes
Nature, 1976FOUR gene clusters have products that seem to participate in antigen binding on T or B lymphocytes. Three (the genes coding for the heavy and light chains of immunoglobulin molecules) are known to code for structural elements of B-cell receptors for antigen.
Hans Binz, Hans Wigzell, Hervé Bazin
openaire +3 more sources
Translation of human immunoglobulin heavy chain mRNA in vitro
Nature, 1977MOUSE immunoglobulin (Ig) mRNAs have been the subject of intensive study. Purification of Ig light chain mRNAs from myeloma or plasmacytoma cells has been monitored by translation in vitro, and studies have been directed towards sequence determination and gene titration Moreover, partial purification of Ig heavy chain mRNA has also been achieved1–5. No
Frans Cramer +2 more
openaire +3 more sources
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.
Annual Review of Immunology, 2006V(D)J recombination assembles antigen receptor variable region genes from component germline variable (V), diversity (D), and joining (J) gene segments.
David H. Jung +3 more
semanticscholar +1 more source
Polymorphism of Heavy-Chain Genes in Immunoglobulins of Wild Mice
Science, 1966The serums of 123 wild mice from six different geographic locations in the United States contain five of the six known heavy-chain antigenic determinants that have been identified in immunoglobulin of inbred laboratory strains of mice. On the basis of the distribution of determinants in inbred strains, 44 of the mice were judged to be heterozygotes of ...
Lieberman, R, Potter, M
openaire +3 more sources
Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus
Current Opinion in Immunology, 2004The production of immunoglobulin heavy chain (IgH) protein in pro-B cells provides feedback to terminate further V(H) gene recombination. This phenomenon is referred to as allelic exclusion. The chromatin structure of the V(H) genes regulates their recombination potential, hence alterations in chromatin are a key factor in allelic exclusion.
Dipanjan Chowdhury, Ranjan Sen
openaire +3 more sources
Addition of glucosamine and mannose to nascent immunoglobulin heavy chains
Biochemistry, 1977We have investigated the process of protein glycosylation in an attempt to answer the question of whether glucosamine and mannose are added to nascent chains prior to chain completion or only to completed chains after release from the ribosome. The MPC 11 mouse plasmacytoma cell line used in these studies synthesizes a glycosylated gamma2b heavy chain ...
W. M. Kuehl, L. W. Bergman
openaire +3 more sources
Immunoglobulin heavy-chain switching in pre-B leukaemias
Nature, 1983Immunoglobulin gene expression is initiated in pre-B cells by rearrangements of heavy-chain variable genes V, D and J, for transcription together with the constant region gene C mu (refs 1-7). The subsequent joining of light-chain V-J genes in the kappa or lambda families leads to formation of complete IgM molecules, which are then expressed on the ...
Max D. Cooper +3 more
openaire +3 more sources
Immunoglobulin Heavy Chain Deficiency
Encyclopedia of Medical Immunology, 2020semanticscholar +1 more source
The Transcription Factor, Bright, and Immunoglobulin Heavy Chain Expression
Immunologic Research, 2001Bright, or B cell regulator of immunoglobulin heavy chain transcription, is a B lymphocyte-specific protein first discovered for its ability to increase immunoglobulin transcription three- to sevenfold in antigen-activated B cells. It interacts with DNA through an ARID, or A/T-rich interaction domain, and is the only member of a previously undescribed ...
openaire +3 more sources