Results 21 to 30 of about 172,498 (401)

Human Immunoglobulin Heavy Chain Genes

Journal of Biological Chemistry, 1989
genes in man, has lagged surprisingly behind similar information in the inbred mouse. The reasons for this are complicated but to some extent are related to the discovery of the myc oncogene. Thus, after genes encoding some of the constant region isotypes as well as the well defined “subgroups,”
J D, Capra, P W, Tucker
openaire   +2 more sources

The Immunoglobulins of Cold-Blooded Vertebrates [PDF]

, 2014
Peer reviewedPublisher ...
Chen, Clem, Cone, Cooper, Crouch, Deza, Grey, Hadji-Azimi, Hsu, Kokubu, Leslie, Magor, Malecek, Mansikka, Patel, Schaerlinger, Schaerlinger, Small, Steiner, Turchin, Wilson, Wu, Zapata   +22 more
core   +2 more sources

Characterization of immunoglobulin heavy chain knockout rats [PDF]

European Journal of Immunology, 2010
AbstractThe rat is a species frequently used in immunological studies but, until now, there were no models with introduced gene‐specific mutations. In a recent study, we described for the first time the generation of novel rat lines with targeted mutations using zinc‐finger nucleases.
Séverine, Ménoret, Anne-L, Iscache, Laurent, Tesson, Séverine, Rémy, Claire, Usal, Michel J, Osborn, Gregory J, Cost, Marianne, Brüggemann, Roland, Buelow, Ignacio, Anegon   +9 more
openaire   +2 more sources

Monoclonal gammopathy of renal significance: Spectrum of diseases and approach to a case

Saudi Journal of Kidney Diseases and Transplantation, 2021
The occurrence of kidney diseases associated with a monoclonal gammopathy in the absence of symptomatic multiple myeloma is increasingly recognized. When the kidney is involved, the monoclonal etiology of these diseases results in clinical and laboratory
Rohit Tewari, Tathagat Chatterjee, Satish Mendonca, Manu Dogra, Suman Kumar Pramanik, Uday Yanamandra   +5 more
doaj   +1 more source

Diversity of immunoglobulin light chain genes in non-teleost ray-finned fish uncovers IgL subdivision into five ancient isotypes [PDF]

, 2018
The aim of this study was to fill important gaps in the evolutionary history of immunoglobulins by examining the structure and diversity of IgL genes in non-teleost ray-finned fish.
Andreyushkova, Daria A, Baranov, Konstantin O, Chikaev, Nikolai A, Gessner, Jörn, Guselnikov, Sergey V, Kulemzin, Sergey V, Makunin, Alexey I, Mechetina, Ludmila V, Najakshin, Alexander M, Schartl, Manfred, Stöck, Matthias, Taranin, Alexander V, Trifonov, Vladimir A, Warren, Wesley C, Wuertz, Sven   +14 more
core   +5 more sources

Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species

Frontiers in Immunology, 2022
Studies in humans and mice indicate the critical role of the surrogate light chain in the selection of the productive immunoglobulin repertoire during B cell development.
Marek Sinkora, Katerina Stepanova, John E. Butler, Marek Sinkora, Simon Sinkora, Jana Sinkorova   +5 more
doaj   +1 more source

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Kaluzab, Brigitte, Schwirzke, Marina, Weidle, Ulrich H., Weiss, Elisabeth H., Weissenhorn, Winfried   +4 more
core   +1 more source

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

mAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton   +7 more
doaj   +1 more source

RAGs and Regulation of Autoantibodies [PDF]

, 2004
Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow.
Casellas, Rafael, Jankovic, Mila, Nussenzweig, Michel C., Wardemann, ­Hedda, Yannoutsos, Nikos   +4 more
core   +1 more source

A comprehensive analysis of immunoglobulin heavy chain genes in the Bactrian camel (Camelus bactrianus) [PDF]

Frontiers of Agricultural Science and Engineering, 2015
Heavy chain only antibodies (HCAbs) represent a rare type of antibody that is devoid of light chains and the CH1 domain that have been reported in cartilaginous fish and camelids.
Zuoxiang LIANG,Tao WANG,Yi SUN,Wenlong YANG,Zhihong LIU,Jing FEI,Ying GUO,Qingwei MA,Qingjie PAN,Liming REN
doaj   +1 more source