Results 31 to 40 of about 62,032 (209)
Next generation Fc scaffold for multispecific antibodies
iScience, 2021 Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for ...
Bram Estes +11 more
doaj +1 more source
Practical Laboratory Medicine, 2021 Heavy chain isotypes of low level monoclonal immunoglobulins are sometimes obscured in serum immunofixation electrophoresis (SIFE) by a heavy background of polyclonal immunoglobulins.
Asad Ullah +4 more
doaj +1 more source
Iraqi Journal of Hematology, 2017 Background: B-chronic lymphocytic leukemia (CLL) is a monoclonal malignancy characterized by an accumulation of small mature-looking B lymphocytes in the blood, bone marrow, and other tissues.
Ghid Nahd Abdul Muhssen +2 more
doaj +1 more source
Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]
, 2015 Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris +7 more
core +1 more source
Immunoglobulin genes and diversity: what we have learned from domestic animals
Journal of Animal Science and Biotechnology, 2012 This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species—cattle, sheep, pigs, and horses—express a full range of Ig heavy chains (IgHs), including μ, δ, γ, ϵ, and α ...
Sun Yi +6 more
doaj +1 more source
Expansion of the preimmune antibody repertoire by junctional diversity in Bos taurus. [PDF]
PLoS ONE, 2014 Cattle have a limited range of immunoglobulin genes which are further diversified by antigen independent somatic hypermutation in fetuses. Junctional diversity generated during somatic recombination contributes to antibody diversity but its relative ...
Jenni Liljavirta +4 more
doaj +1 more source
Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription [PDF]
, 1991 Virus-transformed pre-B cells undergo ordered immunoglobulin (Ig) gene rearrangements during culture. We devised a series of highly sensitive polymerase chain reaction assays for Ig gene rearrangement and unrearranged Ig gene segment transcription to ...
Baltimore, David +2 more
core +5 more sources
Clinical Immunology CommunicationsObjectives: The objective of this study is to evaluate the use of the immunoglobulin heavy/light chain biomarker in the early detection of biochemical relapse in patients with multiple myeloma under treatment.
Carla Azevedo +11 more
doaj +1 more source
Cell Death and Disease, 2023 Using multi-omics analyses including RNAseq, RT-PCR, RACE-PCR, and shotgun proteomic with enrichment strategies, we demonstrated that newborn rat astrocytes produce neural immunoglobulin constant and variable heavy chains as well as light chains. However,
Alice Capuz +19 more
doaj +1 more source
Regulation of B cell fate by chronic activity of the IgE B cell receptor. [PDF]
, 2016 IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Allen, Christopher DC +6 more
core +1 more source