Results 51 to 60 of about 280,511 (396)
Evolution of antigen binding receptors [PDF]
, 1999 This review addresses issues related to the evolution of the complex multigene families of antigen binding receptors that function in adaptive immunity.
Anderson, Michele K. +2 more
core +1 more source
Method for identification of condition-associated public antigen receptor sequences [PDF]
eLife 2018;7:e33050, 2017 Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv +1 more source
Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data [PDF]
Nucleic Acids Research 48 (19) 10702-10712 (2020), 2020 Somatic hypermutations of immunoglobulin (Ig) genes occuring during affinity maturation drive B-cell receptors' ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. However, a rigorous quantification of this bias has been
arxiv +1 more source
Immunoglobulin genes and diversity: what we have learned from domestic animals
Journal of Animal Science and Biotechnology, 2012 This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species—cattle, sheep, pigs, and horses—express a full range of Ig heavy chains (IgHs), including μ, δ, γ, ϵ, and α ...
Sun Yi +6 more
doaj +1 more source
Variants of mouse myeloma cells that produce short immunoglobulin heavy chains.
Proceedings of the National Academy of Sciences of the United States of America, 1974 After mutagenesis of cultured mouse myeloma cells with ICR 191 or Melphalan, variant clones were isolated that synthesized immunoglobulin heavy chains shorter than those produced by the parent.
B. Birshtein +2 more
semanticscholar +1 more source
Cell Death and Disease, 2023 Using multi-omics analyses including RNAseq, RT-PCR, RACE-PCR, and shotgun proteomic with enrichment strategies, we demonstrated that newborn rat astrocytes produce neural immunoglobulin constant and variable heavy chains as well as light chains. However,
Alice Capuz +19 more
doaj +1 more source
Immunoglobulin heavy chain patterns in reactive lymphadenopathy. [PDF]
Journal of Clinical Pathology, 1991 Thirty one lymph nodes taken from 24 benign reactive cases, three cases of angiolymphoid hyperplasia with eosinophilia, one case of Kimura's disease and three cases of Hodgkin's disease, were stained for immunoglobulin heavy chains IgG, IgM, IgA and IgE using the peroxidase-antiperoxidase method.
T Rhodes, M Sundaresan, A B Akosa
openaire +3 more sources
RAGs and Regulation of Autoantibodies [PDF]
, 2004 Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow.
Casellas, Rafael +4 more
core +1 more source
Per-sample immunoglobulin germline inference from B cell receptor deep sequencing data [PDF]
PLoS Comput Biol 15(7): e1007133 (2019), 2017 The collection of immunoglobulin genes in an individual's germline, which gives rise to B cell receptors via recombination, is known to vary significantly across individuals. In humans, for example, each individual has only a fraction of the several hundred known V alleles.
arxiv +1 more source
Inference of B cell clonal families using heavy/light chain pairing information [PDF]
, 2022 Next generation sequencing of B cell receptor (BCR) repertoires has become a ubiquitous tool for understanding the antibody-mediated immune response: it is now common to have large volumes of sequence data coding for both the heavy and light chain subunits of the BCR.
arxiv +1 more source