Results 51 to 60 of about 297,267 (302)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Killer cell immunoglobulin-like receptors and their ligands : assessment of potential diagnostic and immunotherapeutic value [PDF]

, 2014
Human natural killer (NK) cells constitute an important arm of the innate immune system, which participates in protection against viral infections and elimination of malignant diseases.
Czaja, Karol Gustaw
core   +1 more source

Recent Advances in Clinical Glycoproteomics of Immunoglobulins (Igs)

Molecular & Cellular Proteomics, 2016
Antibody glycosylation analysis has seen methodological progress resulting in new findings with regard to antibody glycan structure and function in recent years. For example, antigen-specific IgG glycosylation analysis is now applicable for clinical samples because of the increased sensitivity of measurements, and this has led to new insights in the ...
Plomp, R., Bondt, A., Haan, N. de, Rombouts, Y., Wuhrer, M.   +4 more
openaire   +3 more sources

IgStrand: A universal residue numbering scheme for the immunoglobulin-fold (Ig-fold) to study Ig-proteomes and Ig-interactomes.

PLoS Computational Biology
The Immunoglobulin fold (Ig-fold) is found in proteins from all domains of life and represents the most populous fold in the human genome, with current estimates ranging from 2 to 3% of protein coding regions.
Caesar Tawfeeq, Jiyao Wang, Umesh Khaniya, Thomas Madej, James Song, Ravinder Abrol, Philippe Youkharibache   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Immunoglobulin NGS enhance residual disease detection and prognosis in pediatric Ph+ acute lymphoblastic leukemia

Frontiers in Immunology
In pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ B-ALL), the clinical value of highly sensitive minimal residual disease (MRD) detection by immunoglobulin next-generation sequencing (Ig-NGS), and its role for tracking ...
Lixian Chang, Lixian Chang, Jiao Chang, Jiao Chang, Beibei Zhao, Beibei Zhao, Yun Gu, Yao Zou, Yao Zou, Yumei Chen, Yumei Chen, Ye Guo, Ye Guo, Xiaojuan Chen, Xiaojuan Chen, Wenyu Yang, Wenyu Yang, Yongjuan Duan, Yongjuan Duan, Tianyuan Hu, Tianyuan Hu, Xiaoming Liu, Xiaoming Liu, Min Ruan, Min Ruan, Zefeng Lu, Shixin Lu, Xiaoxia Wang, Li Dong, Jinghua Wu, Yujiao Jia, Yujiao Jia, Xiao Liu, Xiaofan Zhu, Xiaofan Zhu, Li Zhang, Li Zhang   +36 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The properties of CpG islands in the putative promoter regions of human immunoglobulin (Ig) genes

, 2005
CpG island is a GC-rich motif occurred in gene promoter region, which can play important roles in gene silencing and imprinting. Here, we present a set of discriminant functions that can recognize the structural and compositional features of CpG islands ...
Chen, Rong, Guang B. Liu, John D. Pettigrew, Zhao, Kong-Nan, Ya F. Jiang, Liu, Guang B., Rong Chen, Jiang, Ya F., Kong-Nan Zhao, Yan, Hong, Pettigrew, John D., Hong Yan   +11 more
core   +1 more source

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Schwirzke, Marina, Kaluzab, Brigitte, Weissenhorn, Winfried, Weiss, Elisabeth H., Weidle, Ulrich H.   +4 more
core   +1 more source

Target-selective joint polymerase chain reaction: A robust and rapid method for high-throughput production of recombinant monoclonal antibodies from single cells

BMC Biotechnology, 2011
Background During the development of a therapeutic antibody, large numbers of monoclonal antibodies are required to screen for those that are best suited for the desired activity.
Isobe Masaharu, Kurosawa Nobuyuki, Yoshioka Megumi   +2 more
doaj   +1 more source