Results 61 to 70 of about 297,267 (302)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Immunoglobulins in atopic dermatitis with special reference to IgE
Acta Dermato-Venereologica, 1974 Abstract is not availeble.
S, Ohman, S G, Johansson
openaire +2 more sources
Frontiers in Immunology, 2012 High throughput sequencing (HTS) yields tens of thousands to millions of sequences that require a large amount of pre-processing work to clean various artifacts. Such cleaning cannot be performed manually.
Miri eMichaeli +6 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Conditioning murine B cells for immunoglobulin A production In vitro [PDF]
, 2012 The respiratory mucosa is continuously exposed to a myriad of pathogens and allergens that are inhaled during respiration. B cells of the immune system produce immunoglobulin A (IgA) that protects the respiratory mucosa from inhaled pathogens and ...
Goh, Wil
core
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Self-organization of IgE immunoglobulins on phospholipid films [PDF]
Biochemical Journal, 1987 Mouse monoclonal IgE anti-2,6-dinitrophenyl antibody (clone SPE-7) crystallizes in two dimensions when bound to a phospholipid monolayer or bilayer that has been combined with the hapten 2,6-dinitrophenyl groups. The two-dimensional lattice exhibits considerable local disorder, but long-range order is maintained over many unit cells of the lattice. The
openaire +2 more sources
Immunoglobulin G4-Related Pancreatic and Biliary Diseases
Canadian Journal of Gastroenterology, 2013 BACKGROUND: Autoimmune pancreatitis and autoimmune cholangitis are new clinical entities that are now recognized as the pancreaticobiliary manifestations of immunoglobulin (Ig) G4-related disease.
Hisham Al-Dhahab +3 more
doaj +1 more source
Romanian Journal of Laboratory Medicine, 2023 To explore the changes in C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), human leukocyte antigen-B27 (HLA-B27), and immunoglobulin (Ig) (IgA, IgG, and IgM) in patients suffering from ankylosing spondylitis (AS).
Zhu Lixiu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source