Results 61 to 70 of about 106,352 (314)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling.

, 2012
During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Carmen Grijota-Martinez (152374), Luis Garcia-Alonso, Sigrid Baars (152383), Cabedo, H, Emanuelle Donier, Carmen Grijota-Martinez, Gomez-Sanchez, JA, Lakomá, J, Emanuelle Donier (152367), Garcia-Alonso, L, Jose Antonio Gomez-Sanchez (152369), Jarmila Lakomá, Donier, E, Jarmila Lakomá (152379), Luis Garcia-Alonso (152388), Grijota-Martinez, C, Baars, S, Hugo Cabedo, Jose Antonio Gomez-Sanchez, Hugo Cabedo (152396), Sigrid Baars   +20 more
core   +1 more source

Target-selective joint polymerase chain reaction: A robust and rapid method for high-throughput production of recombinant monoclonal antibodies from single cells

BMC Biotechnology, 2011
Background During the development of a therapeutic antibody, large numbers of monoclonal antibodies are required to screen for those that are best suited for the desired activity.
Isobe Masaharu, Kurosawa Nobuyuki, Yoshioka Megumi   +2 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases [PDF]

, 2006
Lineage trees have frequently been drawn to illustrate diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. In order to extract more information from IGV sequences, we developed a novel mathematical method for ...
Gitit Shahaf, Dunn-Walters, D., Avital Steiman-Shimony, Michal Barak, Roshini S. Abraham, Ramit Mehr, Abraham, Roshini S., Mehr, Ramit, Steiman-Shimony, Avital, Barak, M., Steiman-Shimony, A., David I. Stott, Edelman, H., Edelman, Hanna, Barak, Michal, Stott, David I., Mehr, R., Shahaf, G., Dunn-Walters, Deborah, Deborah Dunn-Walters, Hanna Edelman, Shahaf, Gitit, Abraham, R.S., Stott, D.I.   +23 more
core   +1 more source

Automated cleaning and pre-processing of immunoglobulin gene sequences from high-throughput sequencing

Frontiers in Immunology, 2012
High throughput sequencing (HTS) yields tens of thousands to millions of sequences that require a large amount of pre-processing work to clean various artifacts. Such cleaning cannot be performed manually.
Miri eMichaeli, Hila eNoga, Hilla eTabibian-Keissar, Hilla eTabibian-Keissar, Iris eBarshack, Iris eBarshack, Ramit eMehr   +6 more
doaj   +1 more source

Recent Advances in Clinical Glycoproteomics of Immunoglobulins (Igs)

Molecular & Cellular Proteomics, 2016
Antibody glycosylation analysis has seen methodological progress resulting in new findings with regard to antibody glycan structure and function in recent years. For example, antigen-specific IgG glycosylation analysis is now applicable for clinical samples because of the increased sensitivity of measurements, and this has led to new insights in the ...
Plomp, R., Bondt, A., Haan, N. de, Rombouts, Y., Wuhrer, M.   +4 more
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Self-organization of IgE immunoglobulins on phospholipid films [PDF]

Biochemical Journal, 1987
Mouse monoclonal IgE anti-2,6-dinitrophenyl antibody (clone SPE-7) crystallizes in two dimensions when bound to a phospholipid monolayer or bilayer that has been combined with the hapten 2,6-dinitrophenyl groups. The two-dimensional lattice exhibits considerable local disorder, but long-range order is maintained over many unit cells of the lattice. The
openaire   +2 more sources