Results 71 to 80 of about 297,267 (302)

Genomic organisation analysis of novel immunoglobulin-like transcripts in Atlantic salmon (Salmo salar) reveals a tightly clustered and multigene family [PDF]

, 2010
Copyright 2011 Elsevier B.V., All rights reserved.Peer ...
René JM Stet, Anders E Østergaard, Davidson, William S, William S Davidson, Krzysztof P Lubieniecki, Secombes, C.J., Stet, R.J.M., Martin, Samuel A M, Stet, Rene J M, Christopher J Secombes, Ostergaard, A.E., Lubieniecki, Krzysztof P, Østergaard, Anders E, Davidson, W.S., Martin, S.A.M., Secombes, Christopher J, Lubieniecki, K.P., Samuel AM Martin, Lubieniecki Krzysztof P, Stet René JM, Martin Samuel AM, Østergaard Anders E, Secombes Christopher J, Davidson William S   +23 more
core   +1 more source

Immunoglobulin replacement therapies in inborn errors of immunity: a review

Frontiers in Pediatrics
Immunoglobulins (Ig) were used as a therapeutic modality for the first time in a patient with X-linked agammaglobulinemia in 1952 by Colonel Ogden Bruton, decades before the molecular mechanisms causing the disease were unraveled.
Archan Sil, Suprit Basu, Vibhu Joshi, Rakesh Kumar Pilania, Sangeetha Siniah, Deepti Suri, Amit Rawat, Surjit Singh   +7 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.

PLoS Biology, 2014
Somatic hypermutation (SH) generates point mutations within rearranged immunoglobulin (Ig) genes of activated B cells, providing genetic diversity for the affinity maturation of antibodies.
Jean-Marie Buerstedde, Jukka Alinikula, Hiroshi Arakawa, Jessica J McDonald, David G Schatz   +4 more
doaj   +1 more source

SEMA3F (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F) [PDF]

, 2009
Review on SEMA3F (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F), with data on DNA, on the protein encoded, and where the gene is ...
Drabkin, HA, J Roche, Roche, J, HA Drabkin, VA Potiron, Potiron, VA   +5 more
core   +1 more source

IGLoo enables comprehensive analysis and assembly of immunoglobulin heavy-chain loci in lymphoblastoid cell lines using PacBio high-fidelity reads

Cell Reports: Methods
Summary: High-quality human genome assemblies derived from lymphoblastoid cell lines (LCLs) provide reference genomes and pangenomes for genomics studies.
Mao-Jan Lin, Ben Langmead, Yana Safonova
doaj   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

IgAT (Immunoglobulin Analysis Tool): A novel tool for the analysis of human and mouse heavy and light chain transcripts

Frontiers in Immunology, 2012
Sequence analysis of immunoglobulin (Ig) heavy and light chain transcripts can refine categorization of B cell subpopulations and can shed light on the selective forces that act during immune responses or immune dysregulation, such as autoimmunity ...
Tobias eRogosch, Sebastian eKerzel, Kam Hon Hoi, Zhixin (Jason) eZhang, Rolf F. Maier, Gregory C. Ippolito, Michael eZemlin   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

SEMA3B (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B) [PDF]

, 2010
Review on SEMA3B (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B), with data on DNA, on the protein encoded, and where the gene is ...
M Bhattacharyya, R Tamuli, Tamuli, R, Bhattacharyya, M   +3 more
core   +1 more source