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Shared epitopes of avian immunoglobulin light chains
Veterinary Immunology and Immunopathology, 2014Like all jawed vertebrates, birds (Aves) also produce antibodies i.e. immunoglobulins (Igs) as a defence mechanism against pathogens. Their Igs are composed of two identical heavy (H) and light (L) chains which are of lambda isotype. The L chain consists of variable (VL), joining (JL) and constant (CL) region.
Mateja, Benčina +5 more
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Amyloid, 2001
The Congo red-binding fibrils of AL amyloidosis are the most common form of monoclonal immunoglobulin tissue deposition (MIDD). Nonetheless, the less structured deposits found in light chain deposition disease (LCDD) and the similar, but distinct, deposits of light and heavy chain deposition disease (LHCDD) and heavy chain deposition disease (HCDD) can
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The Congo red-binding fibrils of AL amyloidosis are the most common form of monoclonal immunoglobulin tissue deposition (MIDD). Nonetheless, the less structured deposits found in light chain deposition disease (LCDD) and the similar, but distinct, deposits of light and heavy chain deposition disease (LHCDD) and heavy chain deposition disease (HCDD) can
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Light chains of immunoglobulins in human secretions
Clinica Chimica Acta, 1994Immunoglobulin kappa light chains are predominant in normal human serum and a kappa/lambda ratio of 1.7 to 2 has been reported. However, little is known of the partition of light chains in secretions. The levels of IgA, kappa and lambda were assayed by nephelometry in a series of secretions and in normal human serum.
C M, Molé +4 more
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Light chain immunoglobulins as substrates for collagenase
Immunochemistry, 1975Abstract The proteolytic action of collagenase on immunoglobulin light chains has been studied by mean of quantitative determination of N-terminal amino acid residues. L (λ) and L (κ) appear to be susceptible to the enzymatic action and this characteristics is a highly specific and general one.
M A, Coletti-Previero +2 more
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Immunoglobulin light chains modulate polymorphonuclear leucocyte apoptosis
European Journal of Clinical Investigation, 2003AbstractBackground Apoptosis of polymorphonuclear leucocytes (PMNLs) is important for the resolution of inflammation. Recently, we demonstrated that glucose‐modified proteins increase PMNL apoptosis. No protein factors in sera of uraemic patients attenuating PMNL apoptosis have been identified to date.Materials and methods We tested the influence of ...
G, Cohen +3 more
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Interaction between Glycosaminoglycans and Immunoglobulin Light Chains
Biochemistry, 1997Amyloidosis is a pathological process in which normally soluble proteins polymerize to form insoluble fibrils (amyloid). Amyloid formation is found in a number of diseases, including Alzheimer's disease, adult-onset diabetes, and light-chain-associated amyloidosis.
X, Jiang +3 more
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Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis
New England Journal of Medicine, 2021Efstathios Kastritis +2 more
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Lambda light chains in rat immunoglobulins
Immunochemistry, 1973P, Ouerinjean +5 more
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Immunoglobulin Light Chain Amyloidosis
2018Taxiarchis Kourelis, Morie A. Gertz
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Understanding biology to tackle the disease: Multiple myeloma from bench to bedside, and back
Ca-A Cancer Journal for Clinicians, 2014Giada Bianchi, Kenneth C Anderson
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