Results 281 to 290 of about 394,026 (356)

Immunoglobulin heavy chain and binding protein complexes are dissociated in vivo by light chain addition. [PDF]

, 1990
Linda M. Hendershot
openalex   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

A clinical case of B-cell lymphoma in a Japanese Black cow with monoclonal proliferation of B-cells as revealed by polymerase chain reaction based on the immunoglobulin light chain gene. [PDF]

J Vet Med Sci
Nagata T, Harada T, Maezawa M, Chambers JK, Uchida K, Inokuma H.   +5 more
europepmc   +1 more source

Complete covalent structure of a human immunoglobulin D: sequence of the lambda light chain.

, 1983
Yasuo Takahashi, Noboru Takahashi, Daniel Tétaert, Frank W. Putnam   +3 more
openalex   +1 more source

Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line. [PDF]

, 1990
S Kim, E H Humphries, Larry W. Tjoelker, Louise Carlson, Craig B. Thompson   +4 more
openalex   +1 more source

Structural Diversity of Monoclonal CD4 Antibodies and Their Capacity to Block the HIV GP120/CD4 Interaction [PDF]

, 1996
Chen, Ying-Hua, Federle, Christine, Reiter, Christian, Rieber, Ernst P., Riethmüller, Gert, Weiss, Elisabeth H., Weissenhorn, Winfried   +6 more
core   +1 more source

Neoadjuvant Chemotherapy With Cisplatin Up‐Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14‐Mediated EMT Activation

Advanced Science, EarlyView.
Oral squamous cell carcinoma cells exhibit upregulated expression of GSDMD upon exposure to low‐dose cisplatin chemotherapy, which subsequently interacts with MMP14 through its N‐terminal domain, activating the epithelial‒mesenchymal transition (EMT) process and promoting the lymph node metastasis of oral squamous cell carcinoma.
Zixian Huang, Qiming Jiang, Qianyu Zhang, Nan Lu, Xi Rui, Rui Chen, Yan Wang, Yuepeng Wang, Xiaoding Xu, Zhiquan Huang   +9 more
wiley   +1 more source

A new staging system using right atrial strain in patients with immunoglobulin light-chain cardiac amyloidosis. [PDF]

ESC Heart Fail
Usuku H, Yamamoto E, Sueta D, Shinriki R, Oike F, Tabata N, Ishii M, Hanatani S, Hoshiyama T, Kanazawa H, Arima Y, Takashio S, Kawano Y, Oda S, Kawano H, Ueda M, Tsujita K.   +16 more
europepmc   +1 more source

Stem Cell Mobilization and Autologous Transplant for Immunoglobulin Light-Chain Amyloidosis. [PDF]

Hematol Oncol Clin North Am, 2020
Gertz MA, Schonland S.
europepmc   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source