Advanced Science, EarlyView.Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi +7 more
wiley +1 more source
Case Reports in Oncological Medicine, 2016 Heavy chain diseases are rare variants of B-cell lymphomas that produce one of three classes of immunoglobulin heavy chains, without corresponding light chains. We describe two patients with asymptomatic heavy chain monoclonal gammopathy.
Jan Van Keer +4 more
doaj +1 more source
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis. [PDF]
Curr Opin Chem Biol, 2023 Yan NL +4 more
europepmc +1 more source
Study on Antibody-Virus Interaction using Molecular Dynamics: Two Dimensional Simulation on Immunoglobulin Reaction against Human Papillomavirus [PDF]
arXiv, 2013 Human Papillomavirus (HPV) has been known as one of the cause of virus-induced cancer such as cervical cancer and carcinoma. Among other types of cancer, this type has higher chance in being prevented earlier. The main idea is to eradicate the virus as soon as it enters the body by marking it with antibodies; signaling the immune system to dispose of ...
arxiv
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun +10 more
wiley +1 more source
GENETICS OF IMMUNOGLOBULIN κ-CHAINS: CHEMICAL ANALYSIS OF NORMAL HUMAN LIGHT CHAINS OF DIFFERING INV TYPES [PDF]
, 1969 William D. Terry +2 more
openalex +1 more source
α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science, EarlyView.A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro +14 more
wiley +1 more source
Emergence of clonal selection and affinity maturation in an ab initio microscopic model of immunity [PDF]
arXiv, 2007 Mechanisms of immunity, and of the host-pathogen interactions in general are among the most fundamental problems of medicine, ecology, and evolution studies. Here, we present a microscopic, protein-level, sequence-based model of immune system, with explicitly defined interactions between host and pathogen proteins..
arxiv
Advanced Science, EarlyView.LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su +17 more
wiley +1 more source
Gut mycobiome dysbiosis contributes to the development of hypertension and its response to immunoglobulin light chains. [PDF]
Front Immunol, 2022 Zou Y +5 more
europepmc +1 more source