Results 111 to 120 of about 50,405 (295)

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Gut mycobiome dysbiosis contributes to the development of hypertension and its response to immunoglobulin light chains. [PDF]

Front Immunol, 2022
Zou Y, Ge A, Lydia B, Huang C, Wang Q, Yu Y.   +5 more
europepmc   +1 more source

Immunoglobulin κ/λ light chain levels.

, 2013
Intracellular levels of either λ- (MM1.S, OPM-2) or κ- (INA-6) immunoglobulin light chains were determined by FACS analysis (GeoMean) using anti-Ig λ-FITC- and anti-Ig κ-APC antibodies.
Gerhard Jörg (451013), Stefan Knop (387059), Constantin Lapa (452318), Annika Spahmann (501132), Samuel Samnick (451014), Andreas Rosenwald (321), Herrmann Einsele (501133), Andreas K. Buck (451015), Katharina Lückerath (501131)   +8 more
core   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Identification of two rate-limiting steps in the degradation of partially folded immunoglobulin light chains. [PDF]

Front Cell Dev Biol, 2022
Mann MJ, Flory AR, Oikonomou C, Hayes CA, Melendez-Suchi C, Hendershot LM.   +5 more
europepmc   +1 more source

Characterization of Immunoglobulin Free Light Chains Interactome

, 2012
B cell clones, either malignant or benign, normally produce high amounts of monoclonal immunoglobulins (paraproteins). Paraproteins are made up of intact immunoglobulins, single light chains (Free Ig Light Chains – FLC), or more rarely, single heavy ...
Sarto C., Salemi C., DI NOTO, Giuseppe, PAOLINI, Lucia, Brambilla P., CAIMI, Luigi, RICOTTA, Doris   +6 more
core  

Monoclonal origin of B cells producing k, and k immunoglobulin light chains in a patient with chronic lymphocytic leukemia

, 1987
Immunoglobulin gene rearrangements can be used as genetic markers of clonality in the study of B-cell populations [4]. We have therefore analysed the structure and expression of heavy and light chain immunoglobulin genes in lymphocytes of a patient with ...
Gambari R, Lanza F, Castoldi GL, Gandini D, Tomasi P, Del Senno L   +5 more
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

The Proximal Tubule Toxicity of Immunoglobulin Light Chains. [PDF]

Kidney Int Rep, 2021
Sirac C, Batuman V, Sanders PW.
europepmc   +1 more source

Platelet Satellitism and Dual Surface Immunoglobulin Light-Chain Expression in Circulating Splenic Marginal Zone Lymphoma Cells

, 2013
Platelet satellitism is believed to be an in vitro phenomenon induced at room temperature in ethylenediamine tetraacetic acid–anticoagulated blood.
Vial, Ximena, Husain Alsayegh, Naomi Montague, Montague, Naomi, Blackwelder, Patricia, Roberto Ochoa, Byrne, Gerald E., Patricia Blackwelder, Alsayegh, Husain, Gerald E. Byrne, Ximena Vial, Ochoa, Roberto, Al Sayegh, Husain Ala, Byrne, Gerald E   +13 more
core   +1 more source