Results 111 to 120 of about 3,969,240 (284)

Primary hepatic amyloidosis: a mini literature review and five cases report

Annals of Hepatology, 2012
Primary hepatic amyloidosis (PHA) is characterized by abnormal deposition of monoclonal immunoglobulin light chains (AL) in the liver. This rare condition is frequently undiagnosed or misdiagnosed and can be associated with poor prognosis.
Ya-Dong Wang, Cai-Yan Zhao, Hong-Zhu Yin
doaj   +1 more source

Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis. [PDF]

Curr Opin Chem Biol, 2023
Yan NL, Morgan GJ, Petrassi HM, Wilson IA, Kelly JW.   +4 more
europepmc   +1 more source

Immunoglobulin free light chains in clinically isolated syndrome with conversion to multuiple sclerosis

, 2015
This data file represents the concentrations of immunoglobulin free light chains in 4 groups of patients: 1) CIS-MS (clinically isolated syndrome with conversion to multiple sclerosis during 2 years) 2) CIS-nonMS (clinically isolated syndrome without ...
Surkova, Elena, Kochetova, Olga, Lapin, Sergey, Gleb Makshakov (830670), Elena Surkova (830673), Evgeniy Evdoshenko (830675), Olga Kochetova (830672), Sergey Lapin (830674), Vladimir Nazarov (830671), Makshakov, Gleb, Nazarov, Vladimir, Evdoshenko, Evgeniy   +11 more
core   +1 more source

Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]

, 1990
The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Weller, U., Nordmann, J. J., Dayanithi, G., Ahnert-Hilger, G., Gratzl, Manfred   +4 more
core   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

The usefulness of evaluating serum immunoglobulin light free chains concentration in diagnosis of patients with plasma cell disorder [PDF]

, 2013
Patients with plasma cell disorder require a medical examination that will enable in a quick way to make a diagnosis, treatment selection and conduct patient monitoring during drug therapy.
Gumółka, Izabela, Dryńska-Lichoń, Ewa, Basa, Joanna   +2 more
core  

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Free light chains: Eclectic multipurpose biomarker

, 2017
he production of antibodies is accompanied by a slight excess of synthesis of kappa and lambda, immunoglobulin light chains; small amounts of them are released in the peripheral blood and can also be found in various body fluids, such as synovial fluid ...
Gragnani L, Basile U, Napodano C, Gulli F, Rapaccini GL, Mussap M, Pocino K, Zignego AL.   +7 more
core   +1 more source