Results 91 to 100 of about 3,969,240 (284)

Light chain mutations contribute to defining the fibril morphology in systemic AL amyloidosis

Nature Communications
Systemic AL amyloidosis is one of the most frequently diagnosed forms of systemic amyloidosis. It arises from mutational changes in immunoglobulin light chains.
Sara Karimi-Farsijani, Peter Benedikt Pfeiffer, Sambhasan Banerjee, Julian Baur, Lukas Kuhn, Niklas Kupfer, Ute Hegenbart, Stefan O. Schönland, Sebastian Wiese, Christian Haupt, Matthias Schmidt, Marcus Fändrich   +11 more
doaj   +1 more source

Serum free light chain assays not total light chain assays are the standard of care to assess Monoclonal Gammopathies

Revista Brasileira de Hematologia e Hemoterapia, 2016
The diagnosis of Multiple Myeloma is a challenge to the physician due to the non-specific symptoms (anemia, bone pain and recurrent infections) that are commonplace in the elderly population.
Vania Tietsche de Moraes Hungria, Syreeta Allen, Petros Kampanis, Elyara Maria Soares   +3 more
doaj   +1 more source

Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses

, 2002
Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Redegeld FA, van der Heijden MW, Kool M, Heijdra BM, Garssen J, Kraneveld AD, Van Loveren H, Roholl P, Saito T, Verbeek JS, Claassens J, Koster AS, Nijkamp FP.
Koster, A.S., van Loveren, H., Claassens, J., Kool, M., Heijdra, B.M., Nijkamp, F.P., Rhoholl, P., van der Heijden, M.W., Garssen, J., Saito, T., Verbeek, S., Kraneveld, A.D., Redegeld, F.A.   +12 more
core   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Silver nanoparticle-based assay for the detection of immunoglobulin free light chains [PDF]

, 2019
There is a wide spectrum of malignant diseases that are connected with the clonal proliferation of plasma cells, which cause the production of complete immunoglobulins or their fragments (heavy or light immunoglobulin chains).
Anna Lizoń, Lizoń, Anna, Drożdż, Ryszard, Magdalena Wytrwal-Sarna, Ryszard Drożdż, Gajewska, Marta, Wytrwal-Sarna, Magdalena, Marta Gajewska   +7 more
core   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Blood serum free light chain concentration vs. Imunofixation results in patients with monoclonal gammapathy

Current Issues in Pharmacy and Medical Sciences, 2012
Monoclonal gammapathies are a group of diseases characterized by proliferation of plasma clone cells that produce a certain type of homogenic immunoglobulin containing heavy chains of a, g, m, d, e class aside a type of light k or l chains.
Maciej Korpysz , Arleta Malecha-Jędraszek, Helena Donica   +2 more
doaj   +1 more source

Unusual acidic light chains in murine sle serum. [PDF]

, 1984
The sera of autoimmune and other mouse strains were analysed by high resolution two dimensional gel electrophoresis and silver staining. The most striking finding was the presence of unusually acidic immunoglobulin light chains in sera from 4-5 month old
Dermer, G B, Eisenberg, R, Dermer, G, Cohen, P L, Eisenberg, R A, Cohen, P   +5 more
core   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source