Results 121 to 130 of about 248,637 (315)

YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
A patented GSK‐3β inhibitor (GSK‐3βi), new benzothiazepinone compounds (BTZs), YC‐4‐3, can modulate the inflammatory status of macrophages in primary immune thrombocytopenia (ITP), and improve the thrombocytopenia in murine ITP models by directly interacting with endoplasmic reticulum (ER) stress response.
Pengcheng Xu, Lili Ji, Yanxia Zhan, Yang Ou, Xia Shao, Xibing Zhuang, Fanli Hua, Feng Li, Hao Chen, Yong Chu, Yunfeng Cheng   +10 more
wiley   +1 more source

Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications

Frontiers in Immunology
Poultry immunoglobulin genes undergo diversification through homologous recombination (HR) and somatic hypermutation (SHM). Most animals share a similar system in immunoglobulin diversification, with the rare exception that human and murine ...
Hidetaka Seo, Kouji Hirota, Kunihiro Ohta   +2 more
doaj   +1 more source

Free Immunoglobulin Light Chains in Patients with Tick-Borne Encephalitis: Before and after Treatment. [PDF]

J Clin Med, 2021
Gudowska-Sawczuk M, Czupryna P, Moniuszko-Malinowska A, Pancewicz S, Mroczko B.   +4 more
europepmc   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Light chain deposition disease presenting with gastrointestinal disorder as primary manifestation: report of two cases and literature review

Journal of International Medical Research
Light chain deposition disease (LCDD) is an under-recognized condition characterized by deposition of abnormal monoclonal light chains in tissues, leading to organ dysfunction. LCDD involving the gastrointestinal tract is very uncommon, and its diagnosis
Chenxiang Wei, Min Wang, Jiamin Li, Jiajun Su, Jing Huang, Sunwing Tong, Dongye Yang   +6 more
doaj   +1 more source

Free light chains of immunoglobulin as a prognostic factor for some plasmaproliferative diseases [PDF]

Journal of Medical Biochemistry, 2011
Quantitation of monoclonal immuno globulins and their fragments is used for monitoring the plasmaproliferative disease course and the effect of therapy.
Mijušković Zoran, Radović Vesna, Pejović Janko, Tukić Ljiljana, Marjanović Slobodan, Stojanović Jelica   +5 more
doaj  

Immunity to Plasmodium knowlesi H strain malaria in olive baboons [PDF]

Int. J. Integ. Biol. Volume 10, Issue No. 3: 147 -- 152 (2010), 2012
Malaria disease is a major global health and economic development threat. It results in approximately 2.7 million deaths annually. There is currently no vaccine that has been licensed for use against malaria. Studies in animal models, especially non-human primates can lead to the revelation of possible immunological mechanisms that can lead to ...
arxiv  

Bence Jones Proteins and Light Chains of Immunoglobulins [PDF]

, 1971
Carla L. McLaughlin, Alan Solomon
openalex   +1 more source

Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR‐Altered Bladder Cancer

Advanced Science, EarlyView.
Coatomer protein complex subunit α facilitates the transport of the cargo protein LRPPRC across the Golgi complex and enhances its stability, thereby increasing LRPPRC expression; LRPPRC promotes the stability of ID3 mRNA in an m6A‐dependent manner, thereby decreasing the transcriptional activity of p16 and p21, which leads to increased erdafitinib ...
Huayuan Zhao, Xincheng Gao, Yangkai Jiang, Yanchao Yu, Liang Wang, Jiayin Sun, Miao Wang, Xing Xiong, Chao Huang, Hui Zhang, Guosong Jiang   +10 more
wiley   +1 more source

Binding Studies on Heavy-Light Chain Recombinant Hybrid Immunoglobulins a Derived from Murine Myeloma Anti-Fructofuranans [PDF]

, 1978
Dirk G. Streefkerk, Mark Vrana, Cornelis P.J. Glaudemans   +2 more
openalex   +1 more source