Results 171 to 180 of about 3,969,240 (284)

Coronary health index based on immunoglobulin light chains to assess coronary heart disease risk with machine learning: a diagnostic trial. [PDF]

J Transl Med
Ren W, Zhang Z, Wang Y, Wang J, Li L, Shi L, Zhai T, Huang J.   +7 more
europepmc   +1 more source

Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains. [PDF]

Biochemistry, 2019
Misra P, Blancas-Mejia LM, Ramirez-Alvarado M.   +2 more
europepmc   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Temporal Decoupling: A New Paradigm of 4D Photo‐Responsive Carbon Dots Films With Modular Regulation of Color and Deformation

Advanced Science, EarlyView.
This work demonstrates a novel energy regulation strategy using the long‐lived S₁ state as a “kinetic capacitor” to achieve temporally decoupled integration of photoinduced deformation and multicolor fluorescence in naphthalimide‐functionalized carbon dots. This dual‐channel programmable shunting of excited‐state energy establishes a dynamic single‐use
Jianye Zhang, Meichen Meng, Zhimeng Ma, Mingbo Yue, Xiaoyu Xu, Chang Liu, Qiang Fu   +6 more
wiley   +1 more source

Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis. [PDF]

Sci Rep
Bézard M, Vartanian-Grimaldi JS, Henri J, Calin D, Zaroui A, Kharoubi M, Damy T, Agbulut O, Kordeli E.   +8 more
europepmc   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains. [PDF]

J Med Chem
Lederberg OL, Yan NL, Sanchez J, Ren W, Ash C, Wilkens SJ, Qiu H, Qin B, Grant VH, Jackman AB, Stanfield RL, Wilson IA, Petrassi HM, Rhoades D, Kelly JW.   +14 more
europepmc   +1 more source

Urine and Free Immunoglobulin Light Chains as Analytes for Serodiagnosis of Hantavirus Infection. [PDF]

Viruses, 2019
Hepojoki S, Kareinen L, Strandin T, Vaheri A, Holthöfer H, Mustonen J, Mäkelä S, Hedman K, Vapalahti O, Hepojoki J.   +9 more
europepmc   +1 more source

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury. [PDF]

J Clin Invest, 2019
Ying WZ, Li X, Rangarajan S, Feng W, Curtis LM, Sanders PW.   +5 more
europepmc   +1 more source