Results 271 to 280 of about 93,706 (306)

Immunoglobulin Light Chain and Systemic Light-Chain Amyloidosis

2007
Light-chain amyloidosis (AL) is characterized by the clonal expansion of plasma B cells that secrete large amounts of monoclonal immunoglobulin light chains. The free light chains circulate in serum and form amyloid fibrils on vital organs such as the kidney, heart, and liver causing organ failure and eventually death.
Marina Ramirez-Alvarado, Janelle K. De Stigter, Elizabeth M. Baden, Laura A. Sikkink, Richard W. McLaughlin, Anya L. Taboas   +5 more
openaire   +1 more source

Dispersed human immunoglobulin κ light-chain genes

Nature, 1986
The gene segments encoding the constant and variable regions of human immunoglobulin light chains of the kappa type (C kappa, V kappa) have been localized to chromosome 2. The distance between the C kappa and V kappa genes and the number of germline V kappa genes are unknown.
E, Lötscher, K H, Grzeschik, H G, Bauer, H D, Pohlenz, B, Straubinger, H G, Zachau   +5 more
openaire   +2 more sources

Shared epitopes of avian immunoglobulin light chains

Veterinary Immunology and Immunopathology, 2014
Like all jawed vertebrates, birds (Aves) also produce antibodies i.e. immunoglobulins (Igs) as a defence mechanism against pathogens. Their Igs are composed of two identical heavy (H) and light (L) chains which are of lambda isotype. The L chain consists of variable (VL), joining (JL) and constant (CL) region.
Mateja, Benčina, Ivanka, Cizelj, Rebeka Lucijana, Berčič, Mojca, Narat, Dušan, Benčina, Peter, Dovč   +5 more
openaire   +2 more sources

Abnormal immunoglobulin synthesis in monoclonal immunoglobulin light chain and light and heavy chain deposition disease

Amyloid, 2001
The Congo red-binding fibrils of AL amyloidosis are the most common form of monoclonal immunoglobulin tissue deposition (MIDD). Nonetheless, the less structured deposits found in light chain deposition disease (LCDD) and the similar, but distinct, deposits of light and heavy chain deposition disease (LHCDD) and heavy chain deposition disease (HCDD) can
openaire   +2 more sources

Light chains of immunoglobulins in human secretions

Clinica Chimica Acta, 1994
Immunoglobulin kappa light chains are predominant in normal human serum and a kappa/lambda ratio of 1.7 to 2 has been reported. However, little is known of the partition of light chains in secretions. The levels of IgA, kappa and lambda were assayed by nephelometry in a series of secretions and in normal human serum.
C M, Molé, M C, Béne, P M, Montagne, E, Seilles, G C, Faure   +4 more
openaire   +2 more sources

Light chain immunoglobulins as substrates for collagenase

Immunochemistry, 1975
Abstract The proteolytic action of collagenase on immunoglobulin light chains has been studied by mean of quantitative determination of N-terminal amino acid residues. L (λ) and L (κ) appear to be susceptible to the enzymatic action and this characteristics is a highly specific and general one.
M A, Coletti-Previero, J C, Cavadore, C, Tonnelle   +2 more
openaire   +2 more sources

Immunoglobulin light chains modulate polymorphonuclear leucocyte apoptosis

European Journal of Clinical Investigation, 2003
AbstractBackground Apoptosis of polymorphonuclear leucocytes (PMNLs) is important for the resolution of inflammation. Recently, we demonstrated that glucose‐modified proteins increase PMNL apoptosis. No protein factors in sera of uraemic patients attenuating PMNL apoptosis have been identified to date.Materials and methods We tested the influence of ...
G, Cohen, M, Rudnicki, R, Deicher, W H, Hörl   +3 more
openaire   +2 more sources

Interaction between Glycosaminoglycans and Immunoglobulin Light Chains

Biochemistry, 1997
Amyloidosis is a pathological process in which normally soluble proteins polymerize to form insoluble fibrils (amyloid). Amyloid formation is found in a number of diseases, including Alzheimer's disease, adult-onset diabetes, and light-chain-associated amyloidosis.
X, Jiang, E, Myatt, P, Lykos, F J, Stevens   +3 more
openaire   +2 more sources

Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis

New England Journal of Medicine, 2021
Efstathios Kastritis, Giovanni Palladini, Monique C Minnema   +2 more
exaly  

Lambda light chains in rat immunoglobulins

Immunochemistry, 1973
P, Ouerinjean, H, Bazin, V, Starace, A, Beckers, C, Deckers, J F, Heremans   +5 more
openaire   +2 more sources