Results 1 to 10 of about 25,100,658 (282)
Immunoglobulin M Paraproteinaemias [PDF]
Cancers, 2020 Monoclonal paraproteinaemia is an increasingly common reason for referral to haematology services. Paraproteinaemias may be associated with life-threatening haematologic malignancies but can also be an incidental finding requiring only observation ...
L. Girard +5 more
semanticscholar +3 more sources
Structural basis for Fc receptor recognition of immunoglobulin M. [PDF]
Nat Struct Mol Biol, 2023 Immunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and play critical roles in regulating immune responses by activation of immune cells, clearance of immune complexes and regulation of ...
Chen Q +4 more
europepmc +2 more sources
Immunoglobulin M perception by FcμR
Nature, 2023 Immunoglobulin M (IgM) is the first antibody to emerge during embryonic development and the humoral immune response^ 1 . IgM can exist in several distinct forms, including monomeric, membrane-bound IgM within the B cell receptor (BCR) complex, pentameric
Yaxin Li +6 more
semanticscholar +3 more sources
Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. [PDF]
Nat Commun, 2022 Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains ...
Chen Q +4 more
europepmc +2 more sources
Structural insights into immunoglobulin M
Science, 2020 Hefty structures of IgA and IgM complexes Immunoglobulin M (IgM) and IgA are antibody isotypes that can form higher-order secretory complexes (sIgM and sIgA), which allows them to effectively bind and neutralize antigens with low-affinity repetitive ...
Yaxin Li +11 more
semanticscholar +3 more sources
Immunoglobulin M: An Ancient Antiviral Weapon – Rediscovered
Frontiers in Immunology, 2020 Recent discoveries have shed new light onto immunoglobulin M (IgM), an ancient antibody class preserved throughout evolution in all vertebrates. First, IgM – long thought to be a perfect pentamer – was shown to be asymmetric, resembling a quasi-hexamer ...
Siqi Gong +3 more
doaj +2 more sources
Immunoglobulin M Monoclonal Gammopathies of Clinical Significance [PDF]
Frontiers in Oncology, 2022 Immunoglobulin M monoclonal gammopathy of undetermined significance (MGUS) comprises 15-20% of all cases of MGUS. IgM MGUS is distinct from other forms of MGUS in that the typical primary progression events include Waldenstrom macroglobulinaemia and ...
Louis-Pierre Girard +6 more
doaj +2 more sources
Functionality of Immunoglobulin G and Immunoglobulin M Antibody Physisorbed on Cellulosic Films
Frontiers in Bioengineering and Biotechnology, 2017 The functionality and aging mechanism of antibodies physisorbed onto cellulosic films was investigated. Blood grouping antibodies immunoglobulin G (IgG) and immunoglobulin M (IgM) were adsorbed onto smooth cellulose acetate (CAF) and regenerated ...
Ziwei Huang +2 more
doaj +2 more sources
PLoS ONE, 2014 Persistent low-grade systemic inflammation has been increasingly recognized as a common pathological process, and an important contributing factor to cardiovascular diseases and its risk factor, metabolic syndrome.
Kun Song +11 more
doaj +2 more sources