Structural basis for Fc receptor recognition of immunoglobulin M. [PDF]
Nat Struct Mol Biol, 2023 Immunoglobulin Fc receptors are cell surface transmembrane proteins that bind to the Fc constant region of antibodies and play critical roles in regulating immune responses by activation of immune cells, clearance of immune complexes and regulation of ...
Chen Q +4 more
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Structure of the Human Secretory Immunoglobulin M Core [PDF]
bioRxiv, 2020 Immunoglobulins (Ig) A and M are the only human antibodies that form oligomers and undergo transcytosis to mucosal secretions via the polymeric Ig receptor (pIgR).
Nikit Kumar +3 more
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Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. [PDF]
Nat Commun, 2022 Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains ...
Chen Q +4 more
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Non‐functional immunoglobulin G transcripts in a case of hyper‐immunoglobulin M syndrome similar to type 4 [PDF]
, 2004 86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally
John M. Darlow +2 more
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Immunoglobulin M: An Ancient Antiviral Weapon – Rediscovered
Frontiers in Immunology, 2020 Recent discoveries have shed new light onto immunoglobulin M (IgM), an ancient antibody class preserved throughout evolution in all vertebrates. First, IgM – long thought to be a perfect pentamer – was shown to be asymmetric, resembling a quasi-hexamer ...
Siqi Gong +3 more
doaj +2 more sources
Functionality of Immunoglobulin G and Immunoglobulin M Antibody Physisorbed on Cellulosic Films
Frontiers in Bioengineering and Biotechnology, 2017 The functionality and aging mechanism of antibodies physisorbed onto cellulosic films was investigated. Blood grouping antibodies immunoglobulin G (IgG) and immunoglobulin M (IgM) were adsorbed onto smooth cellulose acetate (CAF) and regenerated ...
Ziwei Huang +2 more
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Immunoglobulin M Monoclonal Gammopathies of Clinical Significance [PDF]
Frontiers in Oncology, 2022 Immunoglobulin M monoclonal gammopathy of undetermined significance (MGUS) comprises 15-20% of all cases of MGUS. IgM MGUS is distinct from other forms of MGUS in that the typical primary progression events include Waldenstrom macroglobulinaemia and ...
Louis-Pierre Girard +6 more
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Serum immunoglobulin M concentration is positively related to metabolic syndrome in an adult population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study. [PDF]
PLoS ONE, 2014 Persistent low-grade systemic inflammation has been increasingly recognized as a common pathological process, and an important contributing factor to cardiovascular diseases and its risk factor, metabolic syndrome.
Kun Song +11 more
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Immunoglobulin M Measurement [PDF]
Definitions, 2020 National Cancer Institute
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Immunoglobulin M bullous pemphigoid: An enigma [PDF]
JAAD Case Reports, 2020 Rosalie Baardman, MD +4 more
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