Results 1 to 10 of about 27,444,187 (356)
Immunoglobulin M Paraproteinaemias. [PDF]
Cancers (Basel), 2020 Monoclonal paraproteinaemia is an increasingly common reason for referral to haematology services. Paraproteinaemias may be associated with life-threatening haematologic malignancies but can also be an incidental finding requiring only observation. Immunoglobulin M (IgM) paraproteinaemias comprise 15–20% of monoclonal proteins but pose unique clinical ...
Girard LP +5 more
europepmc +5 more sources
Update on the hyper immunoglobulin M syndromes [PDF]
British Journal of Haematology, 2010 SummaryThe Hyper‐immunoglobulin M syndromes (HIGM) are a heterogeneous group of genetic disorders resulting in defects of immunoglobulin class switch recombination (CSR), with or without defects of somatic hypermutation (SHM). They can be classified as defects of signalling through CD40 causing both a humoral immunodeficiency and a susceptibility to ...
E. Graham Davies, Adrian J. Thrasher
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Diagnosis of toxoplasmosis by joint detection of immunoglobulin A and immunoglobulin M [PDF]
Journal of Clinical Microbiology, 1997 An indirect immunofluorescence test with total anti-human immunoglobulin conjugate (IgG,A,M-IIF) can be used for joint detection of immunoglobulin A (IgA) and IgM antibodies, provided serum IgG is previously absorbed with anti-human IgG. To determine the validity of the IgG,A,M-IIF assay with absorbed sera, the results obtained were compared with those
Gloria Griemberg +2 more
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Toxoplasmosis in immunoglobulin M-suppressed mice [PDF]
Infection and Immunity, 1982 Mice challenged with a pathogenic strain of Toxoplasma gondii develop fatal infections. However, if such mice are initially treated with sulfadiazine (SD), they develop immunity and survive with chronic infections. The role of antibody (Ab) in establishing protective immunity against acute parasitemias and in maintaining chronic infections was ...
Frenkel, J K, Taylor, D W
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Proteolysis of rabbit immunoglobulin M by papain [PDF]
Biochemical Journal, 1974 1. Digestion of rabbit immunoglobulin M (IgM) by papain for 5h, in the absence of reducing agent, gives Fabμ and Fc5μ fragments in high yield. Shorter periods give fragment Fc5μ with one or more Fabμ fragments still attached. 2. Reducing agent in the absence of a denaturant cleaves rabbit IgM into half-subunits, each containing one μ chain and one ...
Barbara M. McIlroy, George T. Stevenson
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Rapid method to detect rubella immunoglobulin M and immunoglobulin A antibodies [PDF]
Journal of Clinical Microbiology, 1975 Immunoglobulin (Ig) G was removed from serum specimens by precipitation with gamma chain-specific anti-human IgG of rabbit origin. The remaining rubella virus-specific IgM (and IgA) antibodies were then detected by the rubella hemagglutination-inhibition test.
H W Doerr, H Shimizu, D Kampa, H Schmitz
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Biosynthesis of the carbohydrate portions of immunoglobulin M [PDF]
Biochemical Journal, 1971 Incorporations of radioactive mannose, galactose and fucose into MOPC 104E mouse plasma-cell tumour suspensions suggest a stepwise addition of carbohydrate residues to immunoglobulin M (IgM) during the process of secretion. Mannose and glucosamine residues are added at an early stage, whereas galactose and fucose are added just before, or at the time ...
Fritz Melchers, R. M. E. Parkhouse
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Hyper Immunoglobulin M Immunodeficiency (Dysgammaglobulinemia) [PDF]
Journal of Clinical Investigation, 1979 The peripheral blood lymphocytes of nine patients with hyper immunoglobulin (Ig)M immunodeficiency were studied in an attempt to define the cellular basis of this disorder. B cells were normal in number but qualitatively abnormal in all patients. Approximately one-half of the B cell consisted of small lymphocytes (7-9 mum in diameter) bearing surface ...
Farah Fs +5 more
openaire +3 more sources
Use of monoclonal antibodies to human immunoglobulin M in "capture" assays for measles and rubella immunoglobulin M [PDF]
Journal of Clinical Microbiology, 1983 Monoclonal antibodies to human immunoglobulin M (IgM) were used in a four-phase enzyme immunofluorescence "capture" assay for determination of IgM antibodies to measles and rubella viruses. Little or no background reactivity was seen in the test system, and interfering effects of rheumatoid factor were avoided by preabsorption of test sera with ...
Bagher Forghani +2 more
openaire +3 more sources
Journal of Dairy Science, 1985 Twenty-three calves were fed colostrum at 110 ml/kg body weight divided into two feedings at 1 and 13 h of age. The concentrations of immunoglobulins were measured in the colostrum fed and in the calves' sera following colostrum feeding. Apparent efficiency of immunoglobulin absorption was calculated for each calf.
T E, Besser +3 more
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