Results 1 to 10 of about 27,295,714 (333)
Immunoglobulin M Paraproteinaemias [PDF]
Cancers, 2020 Monoclonal paraproteinaemia is an increasingly common reason for referral to haematology services. Paraproteinaemias may be associated with life-threatening haematologic malignancies but can also be an incidental finding requiring only observation ...
L. Girard +5 more
semanticscholar +3 more sources
Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. [PDF]
Nat Commun, 2022 Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains ...
Chen Q +4 more
europepmc +2 more sources
Structural insights into immunoglobulin M
Science, 2020 Hefty structures of IgA and IgM complexes Immunoglobulin M (IgM) and IgA are antibody isotypes that can form higher-order secretory complexes (sIgM and sIgA), which allows them to effectively bind and neutralize antigens with low-affinity repetitive ...
Yaxin Li +11 more
semanticscholar +4 more sources
Immunoglobulin M perception by FcμR
Nature, 2023 Immunoglobulin M (IgM) is the first antibody to emerge during embryonic development and the humoral immune response^ 1 . IgM can exist in several distinct forms, including monomeric, membrane-bound IgM within the B cell receptor (BCR) complex, pentameric
Yaxin Li +6 more
semanticscholar +3 more sources
Functionality of Immunoglobulin G and Immunoglobulin M Antibody Physisorbed on Cellulosic Films [PDF]
Frontiers in Bioengineering and Biotechnology, 2017 The functionality and aging mechanism of antibodies physisorbed onto cellulosic films was investigated. Blood grouping antibodies immunoglobulin G (IgG) and immunoglobulin M (IgM) were adsorbed onto smooth cellulose acetate (CAF) and regenerated ...
Ziwei Huang, V. Raghuwanshi, G. Garnier
semanticscholar +5 more sources
Update on the hyper immunoglobulin M syndromes [PDF]
British Journal of Haematology, 2010 The Hyper‐immunoglobulin M syndromes (HIGM) are a heterogeneous group of genetic disorders resulting in defects of immunoglobulin class switch recombination (CSR), with or without defects of somatic hypermutation (SHM).
E. Davies, A. Thrasher
semanticscholar +4 more sources
medRxiv, 2020 SARS-CoV-2 has infected millions of people and is on a trajectory to kill more than one million globally. Virus entry depends on the receptor-binding domain (RBD) of the spike protein. Although previous studies demonstrated anti-spike and -RBD antibodies
J. Klingler +23 more
semanticscholar +1 more source
Immunoglobulin M: An Ancient Antiviral Weapon – Rediscovered
Frontiers in Immunology, 2020 Recent discoveries have shed new light onto immunoglobulin M (IgM), an ancient antibody class preserved throughout evolution in all vertebrates. First, IgM – long thought to be a perfect pentamer – was shown to be asymmetric, resembling a quasi-hexamer ...
Siqi Gong, R. Ruprecht
semanticscholar +1 more source
Diagnosis of toxoplasmosis by joint detection of immunoglobulin A and immunoglobulin M [PDF]
Journal of Clinical Microbiology, 1997 An indirect immunofluorescence test with total anti-human immunoglobulin conjugate (IgG,A,M-IIF) can be used for joint detection of immunoglobulin A (IgA) and IgM antibodies, provided serum IgG is previously absorbed with anti-human IgG. To determine the validity of the IgG,A,M-IIF assay with absorbed sera, the results obtained were compared with those
Gloria Griemberg +2 more
openaire +3 more sources
Toxoplasmosis in immunoglobulin M-suppressed mice [PDF]
Infection and Immunity, 1982 Mice challenged with a pathogenic strain of Toxoplasma gondii develop fatal infections. However, if such mice are initially treated with sulfadiazine (SD), they develop immunity and survive with chronic infections. The role of antibody (Ab) in establishing protective immunity against acute parasitemias and in maintaining chronic infections was ...
Frenkel, J K, Taylor, D W
openaire +2 more sources