Results 251 to 260 of about 385,610 (292)

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

In Situ Amine Formation to Modulate MOF‐Derived PdIn N‐Doped Carbon Catalysts

Advanced Materials, EarlyView.
An amine‐assisted approach converts PdIn‐MOF into PdIn intermetallic nanoparticles embedded in N‐doped carbon. In situ‐generated amines trigger early Pd nucleation, producing smaller PdIn domains than direct pyrolysis. Amine sterics and basicity tune composition and particle size, while solvent and amine co‐determine textural features.
Gonzalo Egea, Jordan Santiago Martinez, M. Asunción Molina, Jaime Mazarío, Lucy Costley‐Wood, Christian Cerezo‐Navarrete, Carlo Marini, Eduardo Villalobos‐Portillo, Andrew M. Beale, Pascual Oña‐Burgos   +9 more
wiley   +1 more source

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Immunoglobulin M pemphigoid

Journal of the American Academy of Dermatology, 2021
Pemphigoid diseases are a heterogeneous group of autoimmune blistering disorders characterized by predominant deposition of immunoglobulin G or immunoglobulin A autoantibodies against structural proteins of the dermoepidermal junction (DEJ). Sole linear immunoglobulin M (IgM) deposits at the DEJ in pemphigoid diseases have been observed; however, IgM ...
Boch, Katharina, Hammers, Christoph M., Goletz, Stephanie, Kamaguchi, Mayumi, Ludwig, Ralf J., Schneider, Stefan W., Zillikens, Detlef, Hadaschik, Eva, Schmidt, Enno   +8 more
openaire   +2 more sources

Immunoglobulin M perception by FcμR

Nature, 2023
L'immunoglobuline M (IgM) est le premier anticorps à émerger au cours du développement embryonnaire et de la réponse immunitaire humorale1. Les IgM peuvent exister sous plusieurs formes distinctes, y compris les IgM monomériques liées à la membrane dans le complexe du récepteur des cellules B (BCR), les IgM pentamériques et hexamériques dans le sérum ...
Yaxin Li, Hao Shen, Ruixue Zhang, Chuanyi Ji, Yuxin Wang, Chen Su, Junyu Xiao   +6 more
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Immunoglobulin M Amyloidosis

Journal of Clinical Oncology, 2009
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Kwong, YL, Khong, PL, Chan, GSW, Lamb, SS   +3 more
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Human hybrid immunoglobulin M containing immunoglobulin A

In Vitro Cellular & Developmental Biology, 1988
Some hybridoma clones made by fusion of a human lymphoblastoid cell line, HO323 with human B lymphocytes, secreted not only IgA but also IgM-like immunoglobulin molecules. The IgM-like immunoglobulin had a molecular size of 900 K which corresponded to that of IgM. Immunochemical analyses revealed that the IgM-like immunoglobulin contained two monomeric
H, Shinmoto, H, Murakami, S, Dosako, K, Yamada, H, Omura   +4 more
openaire   +2 more sources

Structural insights into immunoglobulin M

Science, 2020
Hefty structures of IgA and IgM complexes Immunoglobulin M (IgM) and IgA are antibody isotypes that can form higher-order secretory complexes (sIgM and sIgA), which allows them to effectively bind and neutralize antigens with low-affinity repetitive epitopes, such as those found on the surface of many bacteria and viruses.
Yaxin Li, Guopeng Wang, Ningning Li, Yuxin Wang, Qinyu Zhu, Huarui Chu, Wenjun Wu, Ying Tan, Feng Yu, Xiao-Dong Su, Ning Gao, Junyu Xiao   +11 more
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Immunoglobulin M mutants

European Journal of Immunology, 1980
AbstractMutants of a hybridoma line secreting IgM with anti‐trinitrophenyl specificity were enriched by coupling the hapten to the cell surface and incubating the cells in the presence of complement. In this way, cells secreting wild‐type Ig commit suicide, whereas cells secreting IgM with reduced lytic activity preferentially survive.
Georges Köhler, Marc J. Shulman
openaire   +1 more source