Results 121 to 130 of about 89,812 (215)

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Comparative evaluation of two NGS-based assays for somatic hypermutation analysis of IGHV genes in chronic lymphocytic leukemia. [PDF]

Blood Res
Kang Y, Lee H, Park YJ, Lee ST, Choi JR, Shin S.   +5 more
europepmc   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Concurrent hereditary angioedema type I and common variable immunodeficiency presenting as suspected antibiotic hypersensitivity: Case report and literature discussion. [PDF]

World Allergy Organ J
Urdea D, Mereuta DV, Iorga RE, Pavel-Tanasa M.   +3 more
europepmc   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Development of canine parvovirus-neutralizing monoclonal antibodies from natural host and their germline gene usage. [PDF]

Appl Microbiol Biotechnol
Liu G, Fu P, Zhang X, Kong F, Peng J, Kang D, Pei Y, Li K, Lu Z.   +8 more
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Uncovering diversity in the immunoglobulin heavy chain locus. [PDF]

Cell Genom
Hollenbach JA.
europepmc   +1 more source

Impact of Electrolyte Formulation on the Phase Behavior and Interphase Formation of Sb/Graphite Electrodes for K‐Ion Batteries

Advanced Science, EarlyView.
Electrolyte formulation is shown to govern both interphase chemistry and bulk phase evolution in Sb/graphite anodes for potassium‐ion batteries. A diglyme‐based localized high‐concentration electrolyte promotes a thin inorganic‐rich interphase, suppresses deep graphite potassiation, limits electrode swelling, and stabilizes amorphous KxSb formation ...
Ezzoubair Bendadesse, Max Wacha, Zeynep Erdol, Yanan Sun, Carsten Prinz, Mirko Boin, Manuela Klaus, Tatiana Mishurova, Till Wolfram, Jürgen Janek, Philipp Adelhelm   +10 more
wiley   +1 more source

Pooled analyses of Clostridioides difficile vaccine trials identify baseline predictors for vaccine response. [PDF]

Sci Rep
Stojkov I, Marchioro L, Bekeredjian-Ding I, Hofner B.   +3 more
europepmc   +1 more source