Results 311 to 320 of about 163,653 (347)

The structure of immunoglobulin variable regions in the horned shark,Heterodontus francisci

Immunogenetics, 1978
The heavy and light chains of pooled antibodies of the hybodont shark,Heterodontus francisci (horned shark), were subjected to amino acid sequence analysis. Yield determinations showed that more than 90% of the available polypeptides in the respective pools were sequenced.
J M, Kehoe, J, Sharon, B, Gerber-Jenson, G W, Litman   +3 more
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Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region

Journal of Neurology, 1995
A haplotype marker consisting of three biallelic restriction fragment length polymorphism (RFLP) loci from the VH-2 variable gene family was examined in 124 families with sibling pairs concordant for multiple sclerosis, 178 unrelated patients and 159 unaffected controls to investigate the role of the immunoglobulin heavy chain gene cluster in ...
N W, Wood, S J, Sawcer, H F, Kellar-Wood, P, Holmans, D, Clayton, N, Robertson, D A, Compston   +6 more
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Immunoglobulin Variable Region Usage in Human Intestinal B Lymphocytes

Clinical Immunology and Immunopathology, 1994
The B cell repertoire was studied in intestinal mononuclear cells from normal individuals and patients with inflammatory bowel disease (IBD) by examining Ig heavy chain variable gene (VH) usage. Using reverse transcription of intestinal mucosal RNA followed by polymerase chain reaction with primers specific for each VH family and a housekeeping gene, a
R P, McCabe, W L, Carroll, M, Egan, S M, Cohn, M, Peters   +4 more
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Somatic mutation of immunoglobulin light-chain variable-region genes

Cell, 1981
A single germline immunoglobulin kappa-variable-region gene, VK167, is rearranged and expressed in two myelomas, MOPC167 and MOPC511. Only this single germline gene displays close homology to the expressed genes. Neither of the rearranged, functional genes, however, has a nucleotide sequence that is identical to the germline VK167 gene.
E, Selsing, U, Storb
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Remarkable selective glycosylation of the immunoglobulin variable region in follicular lymphoma

Molecular Immunology, 2008
Follicular lymphoma (FL) generally expresses immunoglobulin (Ig) with somatically mutated variable (V) region genes. Surprisingly, these almost always carry introduced motifs available for N-glycosylation (Asn-X-Ser/Thr). Introduced motifs are uncommon on normal B cells, but are on other germinal center (GC)-associated B-cell malignancies suggesting a ...
McCann, K J, Ottensmeier, C H, Callard, A, Radcliffe, C M, Harvey, D J, Dwek, R A, Rudd, P M, Sutton, B J, Hobby, P, Stevenson, F K   +9 more
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Effect of immunoglobulin variable region structure on C3b and C4b deposition

Molecular Immunology, 1996
Many of the biological activities of immunoglobulins, including interaction with the complement system, are attributed to the structure of the heavy chain constant domains. However, previous studies indicated that immune complexes formed with independently derived isotype-matched pairs of monoclonal antibodies vary with respect to their capacity to ...
K D, White, M B, Frank, S, Foundling, F J, Waxman   +3 more
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Functional and Structural Implications of Variable Region Immunoglobulin Dynamic States

Immunological Investigations, 1988
The consequence of multiple conformational states in the immunoglobulin variable region are considered. Bound ligand is viewed as a stabilizer of one conformer from a series of non-liganded conformers. Kinetic, equilibrium, thermodynamic and crystal formation information are used as supporting evidence for a unique conformer which is the crystallizable
E W, Voss, M A, Dombrink-Kurtzman, S D, Miklasz   +2 more
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Expression of Immunoglobulin Variable Region Antigens on Mouse B Lymphocytes

The Journal of Immunology, 1979
Abstract Rabbit antibodies prepared against two purified 7S BALB/c myeloma proteins, A2 (γ1, κ) and MOPC 195 (γ2b, κ), and solid-phase absorbed so as to contain only anti-heavy (H) chain specificities bound to 32 to 35% of C57BL/6 lymph node lymphocytes (about 80% of the B lymphocytes).
Stanislawski, M, Mitard, M
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Influence of Clonal Selection on the Expression of Immunoglobulin Variable Region Genes

Science, 1984
The humoral immune response of the mouse to certain antigens is characterized by the dominant expression of a single or limited number of related, immunoglobulin variable region (V) structures by antibody-secreting lymphocytes. Such dominance could be due to preferred expression of these V regions in the B cell population prior to the ...
T, Manser, S Y, Huang, M L, Gefter
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An idiotypic determinant formed by both immunoglobulin constant and variable regions

Nature, 1983
Immunoglobulin idiotypes are serologically defined determinants associated with the variable (V) region of antibody molecules (reviewed in refs 1-4). One of the best defined idiotype systems is that borne by the phosphorylcholine (PC)-binding IgA proteins TEPC15 (T15) and HOPC8 (H8).
G, Morahan, C, Berek, J F, Miller
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