A computational study of the statistical mechanics of antibody-antigen conformations [PDF]
arXiv, 2004 We describe the representation of the chemical affinity between the antigen-combining site of the immunoglobulin molecule and the antigen molecule as the probability of the two molecules existing in a bound state. Our model is based on the identification of shape attractors in the configuration space for the joint antibody / antigen combining site ...
arxiv
An MRI assessment of mechanisms underlying lesion growth and shrinkage in multiple sclerosis
Annals of Clinical and Translational Neurology, EarlyView.By applying the tensor model, we analysed lesion orientation and the directionality of lesion expansion/contraction in multiple sclerosis. Each lesion is summarized as an ellipsoid, and the tensor model is applied to calculate lesion anisotropy. From the top to the bottom white matter atlas, surface‐in gradient segmentation and venous atlas used in the
Ermelinda De Meo +9 more
wiley +1 more source
THE COVALENT STRUCTURE OF AN ENTIRE γG IMMUNOGLOBULIN MOLECULE [PDF]
, 1969 Gerald M. Edelman +5 more
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Handling rescue therapy in myasthenia gravis clinical trials: why it matters and why you should care
Annals of Clinical and Translational Neurology, EarlyView.Abstract Myasthenia gravis (MG) clinical trials typically allow rescue therapy during follow‐up in the event of marked worsening of MG symptoms. Failure to appropriately address rescue therapy in defining treatment effects and planning statistical analyses may yield biased estimates, increase false positive rates, or decrease statistical power – all of
Justin M. Leach +3 more
wiley +1 more source
Energetic frustrations in protein folding at residue resolution: a simulation study of homologous immunoglobulin-like \b{eta}-sandwich proteins [PDF]
arXiv, 2017 Nonnative residual interactions have attracted increasing attention in recent protein folding researches. Experimental and theoretical investigations had been set out to catch nonnative contacts that might dominate key events in protein folding. However, energetic frustrations caused by nonnative inter-residue interactions are not systematically ...
arxiv
A Low Molecular Weight Immunoglobulin Antigenically Related to 19 S IgM* [PDF]
, 1967 John D. Stobo, Thomas B. Tomasi
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objectives Intravenous immunoglobulin (IVIg) is an effective treatment for Guillain–Barré syndrome (GBS), but recovery varies between patients. This study aims to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of a single and a second IVIg dose (SID) in patients with GBS.
Sander J. van Tilburg +7 more
wiley +1 more source
An Investigation into Outlier Elimination and Calculation Methods in the Determination of Reference Intervals using Serum Immunoglobulin A as a Model Data Collection [PDF]
arXiv, 2019 Background: Reference intervals are essential to interpret diagnostic tests, but their determination has become controversial. Methods: In this paper parametric, non-parametric and robust reference intervals with Tukey and block elimination are calculated from a dataset of over 32,000 serum immunoglobulin A (IgA) measurements.
arxiv
Amino acid sequence of the Fc region of a human gamma G-immunoglobulin. [PDF]
, 1968 Urs Rutishauser +4 more
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Febrile infection related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus with immune dysregulation as a potential pathologic mechanism. Despite promising results from second‐line immunomodulators, approximately 30% remain refractory to treatment.
Kristen S. Fisher +5 more
wiley +1 more source