Results 31 to 40 of about 157,523 (294)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Immunoglobulins as Radiopharmaceutical Vectors

, 2019
With the introduction of the magic bullet concept by Ehrlich and the subsequent development of hybridoma technology by Kohler and Milstein, the world of target-specific protein-based drugs was opened.
Vugts, Danielle J., Guus A. M. S. van Dongen, van Dongen, Guus A. M. S., Danielle J. Vugts   +3 more
core   +1 more source

Detection of SARS-CoV-2 Specific Antibodies in Saliva Samples

Frontiers in Immunology, 2022
Molecular assays on nasopharyngeal swabs act as a confirmatory test in coronavirus disease (COVID-19) diagnosis. However, the technical requirements of nasopharyngeal sampling and molecular assays limit the testing capabilities.
Siyang Yu, Siyang Yu, Peiyan Zhang, Mingfeng Liao, Juanjuan Zhang, Suisui Luo, Jinglei Zhai, Yaxi Zhang, Jingyan Lin, Jing Yuan, Zheng Zhang, Zheng Zhang, Fuxiang Wang, Lanlan Wei   +13 more
doaj   +1 more source

A Novel Immunoglobulin-Immunoglobulin Interaction in Autoimmunity

PLoS ONE, 2008
Well over six decades since its first description, the Rheumatoid Factor (RF)-autoantibodies recognizing Fc (constant) portion of IgG through their own Fab (antigen binding variable segments)-is believed to have come of age. Autoimmune pancreatitis is a unique form of pancreatitis, biologically characterized by an elevated serum IgG4 concentration ...
Shigeyuki Kawa, Kei Kitahara, Hideaki Hamano, Yayoi Ozaki, Norikazu Arakura, Kaname Yoshizawa, Takeji Umemura, Masao Ota, Sadaaki Mizoguchi, Yasunori Shimozuru, Seiamak Bahram   +10 more
openaire   +4 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Pattern of serum immunoglobulins and free light chain levels among patients diagnosed with multiple myeloma in Southeast Nigeria

International Journal of Medicine and Health Development, 2023
Background: Abnormal plasma cells in multiple myeloma produce excessive amounts of immunoglobulins and free light chains, of which certain patterns predict patient survival.
Ifeyinwa D Nnakenyi, Anazoeze J Madu, Ifeoma C Ajuba, Sunday Ocheni, Gladys U Ilechukwu, Nnenna Ogbodo, Oji A Nnachi   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Correlation between total IgE level and asthma symptom severity in hospitalized children

Journal of Allergy and Clinical Immunology: Global
Background: Status asthmaticus is a common reason for hospitalization and pediatric intensive care unit (PICU) admission among children. While previous studies have demonstrated a correlation between elevated IgE levels and asthma severity in outpatient ...
Tasmia Rezwan, MD, Michelle Perez, MD, Sarah Jacobs, Justina Shafik, William B. Mitchell, MD, Laura A. Conrad, DO, Sara H. Soshnick, DO   +6 more
doaj   +1 more source

TFPI-2 Protects Against Gram-Negative Bacterial Infection

Frontiers in Immunology, 2018
Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix.
Mohamad N. Ali, Mohamad N. Ali, Gopinath Kasetty, Malin Elvén, Saud Alyafei, Sandra Jovic, Arne Egesten, Heiko Herwald, Artur Schmidtchen, Artur Schmidtchen, Artur Schmidtchen, Praveen Papareddy, Praveen Papareddy   +12 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source