Results 31 to 40 of about 127,689 (263)

Pattern of serum immunoglobulins and free light chain levels among patients diagnosed with multiple myeloma in Southeast Nigeria

International Journal of Medicine and Health Development, 2023
Background: Abnormal plasma cells in multiple myeloma produce excessive amounts of immunoglobulins and free light chains, of which certain patterns predict patient survival.
Ifeyinwa D Nnakenyi, Anazoeze J Madu, Ifeoma C Ajuba, Sunday Ocheni, Gladys U Ilechukwu, Nnenna Ogbodo, Oji A Nnachi   +6 more
doaj   +1 more source

A Novel Immunoglobulin-Immunoglobulin Interaction in Autoimmunity

PLoS ONE, 2008
Well over six decades since its first description, the Rheumatoid Factor (RF)-autoantibodies recognizing Fc (constant) portion of IgG through their own Fab (antigen binding variable segments)-is believed to have come of age. Autoimmune pancreatitis is a unique form of pancreatitis, biologically characterized by an elevated serum IgG4 concentration ...
Shigeyuki Kawa, Kei Kitahara, Hideaki Hamano, Yayoi Ozaki, Norikazu Arakura, Kaname Yoshizawa, Takeji Umemura, Masao Ota, Sadaaki Mizoguchi, Yasunori Shimozuru, Seiamak Bahram   +10 more
openaire   +4 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Correlation between total IgE level and asthma symptom severity in hospitalized children

Journal of Allergy and Clinical Immunology: Global
Background: Status asthmaticus is a common reason for hospitalization and pediatric intensive care unit (PICU) admission among children. While previous studies have demonstrated a correlation between elevated IgE levels and asthma severity in outpatient ...
Tasmia Rezwan, MD, Michelle Perez, MD, Sarah Jacobs, Justina Shafik, William B. Mitchell, MD, Laura A. Conrad, DO, Sara H. Soshnick, DO   +6 more
doaj   +1 more source

TFPI-2 Protects Against Gram-Negative Bacterial Infection

Frontiers in Immunology, 2018
Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix.
Mohamad N. Ali, Mohamad N. Ali, Gopinath Kasetty, Malin Elvén, Saud Alyafei, Sandra Jovic, Arne Egesten, Heiko Herwald, Artur Schmidtchen, Artur Schmidtchen, Artur Schmidtchen, Praveen Papareddy, Praveen Papareddy   +12 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Gestational Pemphigoid—From Molecular Mechanisms to Clinical Outcomes: A Case Report and Review of Literature

Life
Gestational pemphigoid is a rare, autoimmune, subepidermal bullous disease with an incidence of 1 in 50,000 pregnancies, displaying itself through pruritic erythema and urticarial papules and plaques that evolve into tense bullae.
Miruna Ioana Cristescu, Cristina Violeta Tutunaru, Anca Panaitescu, Vlad Mihai Voiculescu   +3 more
doaj   +1 more source

Evaluation of Hypogammaglobulinemia in Chronic Lymphocytic Leukemia Patients and Its Relation to Poor Prognostic Factors

Haseki Tıp Bülteni, 2018
Aim:Chronic lymphocytic leukemia (CLL) is a heterogenous disease with variable clinical course. Rai staging system is used for at least 40 years to predict prognosis and need for treatment but more prognostic factors are needed.
Mesut Ayer, Çağan M. Akay, Fatma Aylin Ayer, Deniz Özmen, Tayfun Elibol   +4 more
doaj   +1 more source

Impact of Binge Alcohol Intoxication on the Humoral Immune Response during Burkholderia spp. Infections

Microorganisms, 2019
Burkholderia pseudomallei, the causative agent of melioidosis can occur in healthy humans, yet binge alcohol use is progressively being recognized as a major risk factor.
Ryan M. Moreno, Victor Jimenez, Fernando P. Monroy   +2 more
doaj   +1 more source

Primary Cutaneous Amyloidosis: A Clinical, Histopathological and Immunofluorescence Study [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Primary Localized Cutaneous Amyloidosis (PLCA) is a relatively rare chronic condition characterized by amyloid deposition in dermis without associated deposits in internal organs.
Krati Mehrotra, Rupali Dewan, Jagannath V Kumar, Abhinav Dewan   +3 more
doaj   +1 more source