Results 41 to 50 of about 127,689 (263)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Human body resistance dynamics in the post-covid period

Инфекция и иммунитет
The issue of the state of specific and nonspecific resistance in the post-COVID period and the possible consequences of COVID-19 remains poorly understood.
Ekaterina V. Zhdanova, E. V. Rubtsova, E. G. Kostolomova   +2 more
doaj   +1 more source

Late diagnosis of agammaglobulinemia in an 8-year-old boy

Pediatria i Medycyna Rodzinna, 2016
Chromosome X-linked Bruton agammaglobulinemia is classified as a primary immunodeficiency disorder. It is a genetic condition associated with a mutation in the BTK gene encoding tyrosine kinase.
Małgorzata Sopińska, Karolina Kapusta, Edyta Heropolitańska-Pliszka, Anna Jung, Bolesław Kalicki   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mass spectrometry-based analysis of rheumatoid factor

Frontiers in Immunology
IntroductionRheumatoid factor (RF) are autoantibodies that are found in approximately two thirds of patients with rheumatoid arthritis, a chronic autoimmune disease characterized by potentially destructive inflammation of the joints.
Jonas De Leeuw, Jonas De Leeuw, Birthe Michiels, Birthe Michiels, Rita Derua, Rita Derua, Tom Dehaemers, Tom Dehaemers, Doreen Dillaerts, Doreen Dillaerts, Maaike Cockx, Maaike Cockx, Maaike Cockx, Glynis Frans, Glynis Frans, Sebastien Christian Carpentier, Patrick Verschueren, Patrick Verschueren, Xavier Bossuyt, Xavier Bossuyt   +19 more
doaj   +1 more source

Thrombocytopenia in the Course of COVID-19 Infection

European Journal of Case Reports in Internal Medicine, 2020
We report three cases of severe thrombocytopenia during COVID-19 infection associated with either cutaneous purpura or mucosal bleeding. The initial investigations ruled out other causes of thrombocytopenia.
Noel Lorenzo-Villalba, Abrar-Ahmad Zulfiqar, Marc Auburtin, Marie Helene Schuhmacher, Alain Meyer, Yasmine Maouche, Olivier Keller, Emmanuel Andres   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Chronic sinusitis in a patient with selective IgG4 subclass deficiency controlled with enriched immunoglobulins

Clinical Case Reports, 2017
Key Clinical Message A 71‐year‐old female patient with no major history of infection had presented with recurrent chronic purulent sinusitis over the past 3 years.
Gérard Dine, Nadia Ali‐Ammar, Said Brahimi, Yves Rehn   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of a combined clostridial vaccine on cytokine and immunoglobulin levels in lambs

Revista Científica
Infections caused by clostridial agents are difficult to treat and have a high mortality rate. This study aimed to determine the effects of the recommended dose of a commercial clostridial vaccine on serum levels of TNF–α, IL–1β, IL–6, and IL–10, and ...
Rahmi Canbar, Elmas Ulutas, Muhittin Uslu, Enver Yazar   +3 more
doaj   +1 more source