Results 71 to 80 of about 853,198 (295)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Wild Birds’ Genetic Resources Bank: Feather Follicle Cell Culture as a Possible Source of Stem Cells

Methods and Protocols
Follicular cells represent a valuable resource for genetic research, biotechnology and cryopreservation in biobanks, particularly for the conservation of endangered species.
Yasmin Godoi dos Reis, Maria Eduarda Pralon Guerra, Meline de Paula Coutinho, Sarah Ingrid Pinto Santos, Bruna Dias Mota, Lauriene Luiza de Souza Munhoz, Diogo Pascoal Rossetti, Daniele dos Santos Martins   +7 more
doaj   +1 more source

OUR EXPERIENCE OF IMMUNOHISTOCHEMICAL ASSAY IN BREAST CANCER

Паёми Сино, 2020
Objective: Analysis of the first experience of immunohistochemical (IHC) diagnostics of breast cancer (BC) in the Republic of Tajikistan for 2018- 2020. Methods: The results of the IHC study of tumor samples obtained by trephine biopsy in 142 patients
S.R. RASULOV, SH.A. VASIKHOV
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Detection of putative stem-cell markers in invasive ductal carcinoma of the breast by immunohistochemistry: does it improve prognostic/predictive assessments?

, 2016
Experimental evidences from the last 2 decades supports the existence of a special type of neoplastic cell with stem-like features [cancer stem cell (CSC)] and their role in the pathophysiology and therapeutic resistance of breast cancerHowever, their ...
Oliveira, Rodrigo V., Soares, Fernando A., Rocha, Rafael M., Vassallo, José, Schenka, André A., Souza, Philipi C., Souza, Valéria B.   +6 more
core   +1 more source

Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine:Part 1: Fit-for-Purpose Approach to Classification of Clinical Immunohistochemistry Biomarkers [PDF]

, 2017
The numbers of diagnostic, prognostic, and predictive immunohistochemistry (IHC) tests are increasing; the implementation and validation of new IHC tests, revalidation of existing tests, as well as the on-going need for daily quality assurance monitoring
Merdol Ibrahim, Clive R. Taylor, J. Han van Krieken, Torlakovic, Emina E, Swanson, Paul E., Nielsen, Soren, Glenn D. Francis, Krieken, J.H.J.M. van, Torlakovic, Emina E., D'Arrigo, Corrado, Gilks, C Blake, Nielsen, Søren; id_orcid, Hall, J.A., Jacqueline A. Hall, Hall, Jacqueline A, Corrado D’Arrigo, Francis, G.D., Cheung, Carol C., Hornick, J.L., Soren Nielsen, Dietel, M., Marchetti, Antonio, Marchetti, A., Taylor, Clive R., Cheung, Carol C, Torlakovic, E.E., Jason L. Hornick, Cheung, C.C., Taylor, C.R., Hornick, Jason L, IBRAHIM, M., van Krieken, J. Han, Nielsen, S., Gilks, C. Blake, Francis, Glenn, Dietel, Manfred, Vyberg, M., Swanson, P.E., Keith Miller, Gilks, C.B., Hornick, Jason L., Zhou, Xiaoge, Manfred Dietel, D'Arrigo, C., Miller, K., Antonio Marchetti, Zhou, X., Hall, Jacqueline A., Paul E. Swanson, Francis, Glenn D, Vyberg, Mogens, Xiaoge Zhou, Miller, Keith, Mogens Vyberg, Ibrahim, Merdol, Taylor, Clive R, van Krieken, J Han, Carol C. Cheung, Emina E. Torlakovic, Swanson, Paul E, C. Blake Gilks   +60 more
core   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Histological and Immunohistochemical Analysis of Fetal Hypoplastic Lungs: Preliminary Study [PDF]

, 2000
To investigate cellular growth and differentiation of the airway epithelium of the human fetal lung using immunohistochemistry, with a particular focus on cases of pulmonary hypoplasia.
Miura, Kiyonori, Moriyama, Shingo, Ishimaru, Tadayuki, Masuzaki, Hideaki, Yoshimura, Shuichiro, Fujishita, Akira   +5 more
core  

A Critical Evaluation of sst3 and sst5 Immunohistochemistry in Human Pituitary Adenomas. [PDF]

, 2018
BACKGROUND Somatostatin receptor (sst) overexpression in neuroendocrine tumors allows sst-targeted tumor imaging and therapy with long-acting, cold, or radioactive somatostatin analogs.
Reubi, J.C., Christ, E., Körner, M., Beck, J., Waser, Beatrice   +4 more
core   +1 more source