Results 51 to 60 of about 799,681 (300)

Neuroprotective Effects of Myricetin on PTZ-Induced Seizures in Mice: Evaluation of Oxidation, Neuroinflammation and Metabolism, and Apoptosis in the Hippocampus

Current Issues in Molecular Biology
Epilepsy is one of the most frequently diagnosed neurological diseases, but the neurobiological basis of the disease remains poorly understood. Immunophenotyping CBA mice brain (NeuN and caspase-8) in parallel with hippocampal neurons’ functional status ...
Grigory Demyashkin, Ekaterina Blinova, Migran Grigoryan, Mikhail Parshenkov, Polina Skovorodko, Vladimir Ius, Anastasia Lebed, Petr Shegay, Andrei Kaprin   +8 more
doaj   +1 more source

Significant Acute Response of Brain-Derived Neurotrophic Factor Following a Session of Extreme Conditioning Program Is Correlated With Volume of Specific Exercise Training in Trained Men

Frontiers in Physiology, 2018
Several studies have demonstrated an acute and chronic increase of brain-derived neurotrophic factor (BDNF) in relation to different types of physical exercise. Currently, many individuals seek physical training strategies that present different types of
Emy S. Pereira, Emy S. Pereira, Walter Krause Neto, Atilio S. Calefi, Mariana Georgetti, Larissa Guerreiro, Cesar A. S. Zocoler, Eliane F. Gama, Eliane F. Gama   +8 more
doaj   +1 more source

Sedentary fish as indicators of changes in the river flow rate after impoundment

Ecological Indicators, 2021
The natural flood pulse of the Amazon basin has been altered progressively by the installation of hydroelectric dams, which have had a potentially adverse impact on the local fauna.
Yanne A. Mendes, Renata S. Oliveira, Luciano F.A. Montag, Marcelo C. Andrade, Tommaso Giarrizzo, Rossineide M. Rocha, Maria Auxiliadora P. Ferreira   +6 more
doaj   +1 more source

Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine:Part 1: Fit-for-Purpose Approach to Classification of Clinical Immunohistochemistry Biomarkers [PDF]

, 2017
The numbers of diagnostic, prognostic, and predictive immunohistochemistry (IHC) tests are increasing; the implementation and validation of new IHC tests, revalidation of existing tests, as well as the on-going need for daily quality assurance monitoring
Merdol Ibrahim, Clive R. Taylor, J. Han van Krieken, Torlakovic, Emina E, Swanson, Paul E., Nielsen, Soren, Glenn D. Francis, Krieken, J.H.J.M. van, Torlakovic, Emina E., D'Arrigo, Corrado, Gilks, C Blake, Nielsen, Søren; id_orcid, Hall, J.A., Jacqueline A. Hall, Hall, Jacqueline A, Corrado D’Arrigo, Francis, G.D., Cheung, Carol C., Hornick, J.L., Soren Nielsen, Dietel, M., Marchetti, Antonio, Marchetti, A., Taylor, Clive R., Cheung, Carol C, Torlakovic, E.E., Jason L. Hornick, Cheung, C.C., Taylor, C.R., Hornick, Jason L, IBRAHIM, M., van Krieken, J. Han, Nielsen, S., Gilks, C. Blake, Francis, Glenn, Dietel, Manfred, Vyberg, M., Swanson, P.E., Keith Miller, Gilks, C.B., Hornick, Jason L., Zhou, Xiaoge, Manfred Dietel, D'Arrigo, C., Miller, K., Antonio Marchetti, Zhou, X., Hall, Jacqueline A., Paul E. Swanson, Francis, Glenn D, Vyberg, Mogens, Xiaoge Zhou, Miller, Keith, Mogens Vyberg, Ibrahim, Merdol, Taylor, Clive R, van Krieken, J Han, Carol C. Cheung, Emina E. Torlakovic, Swanson, Paul E, C. Blake Gilks   +60 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Immunohistochemistry in Ophthalmology

Delhi Journal of Ophthalmology, 2017
Immunohistochemistry is a pathological technique wherein the distribution of a particular protein or lipid antigen in a tissue specimen is determined using a combination of immunological, histochemical and biochemical principles.
Smriti Nagpal Gupta, RK Saran, Okram Birbala, Pragya Saini, Lavi Mangala   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Features of Appendix and the Characteristics of Appendicitis Development in Children with COVID-19

Biomedicines
Background: Research on the subject of the influence of SARS-CoV-2 mechanisms on human homeostasis remains an actual problem. Particular interest is the study of pathomorphological changes in the appendix in children with COVID-19.
Grigory Demyashkin, Konstantin Gorokhov, Vladimir Shchekin, Matvey Vadyukhin, Artem Matevosyan, Arina Rudavina, Anna Pilipchuk, Alina Pilipchuk, Svetlana Kochetkova, Dmitrii Atiakshin, Petr Shegay, Andrey Kaprin   +11 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source