Results 41 to 50 of about 799,681 (300)
Literature review: Personalised medicine tools for antidepressant management [PDF]
Scripta MedicaAntidepressants are widely used in clinical practice, including for conditions beyond major depression (MD) disorders. However, clinicians still lack reliable tools to match patients with the right drug.
Parshenkov Mikhail Alekseevich +3 more
doaj +1 more source
Developing Monoclonal Antibodies for Immunohistochemistry
Cells, 2022 The experiences of a laboratory which pioneered the application of monoclonal antibodies to diagnostic histochemistry is described. This was achieved in four key steps: (1) Monoclonal antibodies were successfully produced to replace the difficult-to ...
Jacqueline Cordell
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Immunohistochemistry in the Postmortem Diagnosis of Sepsis: A Systematic Review
, 2019 It is not uncommon for the forensic pathologist to question whether a deceased person had experienced sepsis that could have either been the cause of or contributed to the person's death.
Francesco Ventura +3 more
core +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Immunohistochemistry findings.
, 2022 Immunohistochemistry findings.
Thomas Briese (67195) +12 more
core +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Antigen retrieval immunohistochemistry and molecular morphology in the year 2001
, 2001 The impact of the antigen retrieval (AR) technique upon diagnostic immunohistochemistry (IHC) and upon research has been demonstrated by numerous of articles and more than a dozen major reviews.
Shi, S R, Cote, R J, Taylor, C R
core +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source