Results 41 to 50 of about 875,318 (295)

Automated Segmentation of Cells with IHC Membrane Staining [PDF]

, 2011
This study presents a fully automated membrane segmentation technique for immunohistochemical tissue images with membrane staining, which is a critical task in computerized immunohistochemistry (IHC).
A Acquaviva, Ficarra, Elisa, Acquaviva, Andrea, Di Cataldo, Santa, E Macii, Macii, Enrico, E Ficarra, S D Cataldo   +7 more
core   +1 more source

Immunohistochemistry in Dermatopathology [PDF]

Archives of Pathology & Laboratory Medicine, 2015
Context Immunohistochemistry is not a diagnostic test but a highly valuable tool that requires interpretation within a context. Objective To review the current status and limitations of immunohistochemistry in dermatopathology.
openaire   +2 more sources

Immunohistochemistry for Protein Detection in Esophageal Squamous Cell Carcinoma

, 2020
Immunohistochemistry is the identification of a cell protein by a specific antibody targeting that protein. It is the most common ancillary test to study the pathology of cancer.
Kais Kasem, Kasem, K, Lam, AK, Alfred K. Lam   +3 more
core   +1 more source

Increased MYD88 blood transcript in a mouse model of Alzheimer’s disease

BMC Neuroscience, 2022
Background Neuroinflammation plays a prominent role in Alzheimer’s disease (AD), both in pathogenesis and disease progression. It has been shown that TLR/MYD88 signaling is involved in the chronic low-grade sterile inflammation associated with AD ...
Catalina Anca Cucos, Maria Dobre, Elena Mihaela Dragnea, Gina Manda, Elena Milanesi   +4 more
doaj   +1 more source

No Mutation Detected in Five Hot Spot Codons of the Tp53 Gene by Restriction Site Mutation Analysis in Patients with Carcinoma of the Tongue

The International Journal of Biological Markers, 2010
The present study evaluated 5 of the 8 main TP53 mutation hot spots in cancer by restriction site mutation analysis and compared the results with p53 protein expression in patients with cancer of the tongue.
Hemangini H. Vora, Shalvi V. Mehta, Shilin N. Shukla, Pankaj M. Shah   +3 more
doaj   +1 more source

Non-specific binding of antibodies in immunohistochemistry: Fakes and facts [PDF]

, 2011
Protocols for blocking non-specific antibody (Ab) binding in immunohistochemistry are based on rather contradictory and outdated reports. This prompted us to prove, whether non-specific Ab binding may really lead to unwanted background staining in ...
Vera Samoilova, Werner Boecker, Markus Tiemann, Igor Buchwalow   +3 more
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Literature review: Personalised medicine tools for antidepressant management [PDF]

Scripta Medica
Antidepressants are widely used in clinical practice, including for conditions beyond major depression (MD) disorders. However, clinicians still lack reliable tools to match patients with the right drug.
Parshenkov Mikhail Alekseevich, Dyakonova Anna Nikolaevna, Skovorodko Polina Petrovna, Rodionova Galina Mikhailovna   +3 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source