Results 61 to 70 of about 853,198 (295)

Immunohistochemistry findings.

, 2022
Immunohistochemistry findings.
Thomas Briese (67195), Todd M. Bell (12072418), Heather L. Esham (12072424), Paul Facemire (12072421), Lisa E. Hensley (7164947), W. Ian Lipkin (67196), Sara C. Johnston (10073925), Ginger C. Donnelly (12072427), Curtis Cline (12072415), Anna N. Honko (12072433), Joshua C. Johnson (12072430), Joshua D. Shamblin (9010217), Xiankun Zeng (623049)   +12 more
core   +1 more source

Neuroprotective Effects of Myricetin on PTZ-Induced Seizures in Mice: Evaluation of Oxidation, Neuroinflammation and Metabolism, and Apoptosis in the Hippocampus

Current Issues in Molecular Biology
Epilepsy is one of the most frequently diagnosed neurological diseases, but the neurobiological basis of the disease remains poorly understood. Immunophenotyping CBA mice brain (NeuN and caspase-8) in parallel with hippocampal neurons’ functional status ...
Grigory Demyashkin, Ekaterina Blinova, Migran Grigoryan, Mikhail Parshenkov, Polina Skovorodko, Vladimir Ius, Anastasia Lebed, Petr Shegay, Andrei Kaprin   +8 more
doaj   +1 more source

Significant Acute Response of Brain-Derived Neurotrophic Factor Following a Session of Extreme Conditioning Program Is Correlated With Volume of Specific Exercise Training in Trained Men

Frontiers in Physiology, 2018
Several studies have demonstrated an acute and chronic increase of brain-derived neurotrophic factor (BDNF) in relation to different types of physical exercise. Currently, many individuals seek physical training strategies that present different types of
Emy S. Pereira, Emy S. Pereira, Walter Krause Neto, Atilio S. Calefi, Mariana Georgetti, Larissa Guerreiro, Cesar A. S. Zocoler, Eliane F. Gama, Eliane F. Gama   +8 more
doaj   +1 more source

Sedentary fish as indicators of changes in the river flow rate after impoundment

Ecological Indicators, 2021
The natural flood pulse of the Amazon basin has been altered progressively by the installation of hydroelectric dams, which have had a potentially adverse impact on the local fauna.
Yanne A. Mendes, Renata S. Oliveira, Luciano F.A. Montag, Marcelo C. Andrade, Tommaso Giarrizzo, Rossineide M. Rocha, Maria Auxiliadora P. Ferreira   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Immunohistochemistry in Ophthalmology

Delhi Journal of Ophthalmology, 2017
Immunohistochemistry is a pathological technique wherein the distribution of a particular protein or lipid antigen in a tissue specimen is determined using a combination of immunological, histochemical and biochemical principles.
Smriti Nagpal Gupta, RK Saran, Okram Birbala, Pragya Saini, Lavi Mangala   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Features of Appendix and the Characteristics of Appendicitis Development in Children with COVID-19

Biomedicines
Background: Research on the subject of the influence of SARS-CoV-2 mechanisms on human homeostasis remains an actual problem. Particular interest is the study of pathomorphological changes in the appendix in children with COVID-19.
Grigory Demyashkin, Konstantin Gorokhov, Vladimir Shchekin, Matvey Vadyukhin, Artem Matevosyan, Arina Rudavina, Anna Pilipchuk, Alina Pilipchuk, Svetlana Kochetkova, Dmitrii Atiakshin, Petr Shegay, Andrey Kaprin   +11 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source