Results 61 to 70 of about 799,681 (300)

Studies on Expression of Aldehyde Dehydrogenase in Normal and Cancerous Tissues of Thyroids

, 2015
Recently published articles have reported the controversial data regarding expression of aldehyde dehydrogenase isozyme 1A1 (ALDH1A1), a potential candidate marker for normal and cancer stem cells (CSCs), in thyroid tissues.
Nakashima, Masahiro, Minami, Shigeki, Shimamura, Mika, Nagayama, Yuji, Kurashige, Tomomi, Yasui, Kazuaki, Matsuse, Michiko, Mitsutake, Norisato, Eguchi, Susumu   +8 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Detection of putative stem-cell markers in invasive ductal carcinoma of the breast by immunohistochemistry: does it improve prognostic/predictive assessments?

, 2016
Experimental evidences from the last 2 decades supports the existence of a special type of neoplastic cell with stem-like features [cancer stem cell (CSC)] and their role in the pathophysiology and therapeutic resistance of breast cancerHowever, their ...
Oliveira, Rodrigo V., Soares, Fernando A., Rocha, Rafael M., Vassallo, José, Schenka, André A., Souza, Philipi C., Souza, Valéria B.   +6 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Wild Birds’ Genetic Resources Bank: Feather Follicle Cell Culture as a Possible Source of Stem Cells

Methods and Protocols
Follicular cells represent a valuable resource for genetic research, biotechnology and cryopreservation in biobanks, particularly for the conservation of endangered species.
Yasmin Godoi dos Reis, Maria Eduarda Pralon Guerra, Meline de Paula Coutinho, Sarah Ingrid Pinto Santos, Bruna Dias Mota, Lauriene Luiza de Souza Munhoz, Diogo Pascoal Rossetti, Daniele dos Santos Martins   +7 more
doaj   +1 more source

OUR EXPERIENCE OF IMMUNOHISTOCHEMICAL ASSAY IN BREAST CANCER

Паёми Сино, 2020
Objective: Analysis of the first experience of immunohistochemical (IHC) diagnostics of breast cancer (BC) in the Republic of Tajikistan for 2018- 2020. Methods: The results of the IHC study of tumor samples obtained by trephine biopsy in 142 patients
S.R. RASULOV, SH.A. VASIKHOV
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Histological and Immunohistochemical Analysis of Fetal Hypoplastic Lungs: Preliminary Study [PDF]

, 2000
To investigate cellular growth and differentiation of the airway epithelium of the human fetal lung using immunohistochemistry, with a particular focus on cases of pulmonary hypoplasia.
Miura, Kiyonori, Moriyama, Shingo, Ishimaru, Tadayuki, Masuzaki, Hideaki, Yoshimura, Shuichiro, Fujishita, Akira   +5 more
core  

Densitometric measurement in absolute values of estrogen receptors by immunohistochemistry in breast cancer frozen sections

, 1999
Immunohistochemical evaluation is, at present, the most reliable method to evaluate estrogen receptors (ERs) in breast cancer samples. Various quantitative 'scoring' systems have been developed to evaluate both the percentage of ER-positive nuclei and ...
Pagani, R, Santeusanio, G, SPAGNOLI, LUIGI GIUSTO, MAURIELLO, ALESSANDRO, SANTEUSANIO, GIUSEPPE, Mauriello, A, ANEMONA, LUCIA, Anemona, L, Bonanno, E, BONANNO, ELENA, Spagnoli, Lg   +10 more
core   +1 more source

Immunostaining of skeletal tissues [PDF]

, 2011
Peer ...
Tobias B. Kurth, De Bari, Cosimo, Cosimo De Bari, Kurth TB, Kurth, Tobias B, De Bari C   +5 more
core   +1 more source