Cytotoxic immunological synapses [PDF]
Immunological Reviews, 2010 Summary: One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by a cytotoxic immunological synapse. While traditionally thought of as innate immune cells, natural killer (NK) cells are now appreciated to have the ...
Michael L. Dustin, Eric O. Long
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Cx43-Gap Junctions Accumulate at the Cytotoxic Immunological Synapse Enabling Cytotoxic T Lymphocyte Melanoma Cell Killing [PDF]
International Journal of Molecular Sciences, 2019 Upon tumor antigen recognition, cytotoxic T lymphocytes (CTLs) and target cells form specialized supramolecular structures, called cytotoxic immunological synapses, which are required for polarized delivery of cytotoxic granules. In previous reports, we described the accumulation of connexin 43 (Cx43)-formed gap junctions (GJs) at natural killer (NK ...
Francisca Hofmann +6 more
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Function-specific variations in the immunological synapses formed by cytotoxic T cells [PDF]
Proceedings of the National Academy of Sciences, 2003 CD8+ cytotoxic T lymphocytes (CTLs) provide defense against intracellular pathogens and tumors by recognizing and subsequently destroying infected or transformed cells. Recognition is achieved by T cell receptors (TCRs) on the CTL binding to non-self-peptide fragments presented in the cleft of class I MHC molecules (peptide–MHC complexes) on the ...
Darrell J. Irvine
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Genetic, immunological, and cytotoxic comparisons of Legionella proteolytic activities [PDF]
Infection and Immunity, 1989 Several strains of Legionella pneumophila and other species of Legionella with proteolytic activities were compared by assays, including Southern hybridizations and Western immunoblots, to determine their proteolytic, hemolytic, and cytotoxic activities. Only proteases from strains of L.
F D Quinn, M G Keen, Lucy S. Tompkins
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Epitope-level analysis of cross-reactive human HLA antibodies against genetically modified swine leukocyte antigens in xenotransplantation [PDF]
Frontiers in ImmunologyIntroductionXenotransplantation using genetically modified pigs is a promising solution to organ shortages, particularly for highly sensitized patients with broad anti-HLA sensitization who lack compatible allografts.
Sang-Ik Cho +8 more
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Anti-inflammatory effect of amalgam on periapical lesion cells in culture [PDF]
Vojnosanitetski Pregled, 2021 Background/Aim. Amalgam has been used for years in dentistry, but the controversy on its adverse effects, both on local oral/dental tissues and systemic health, still exists.
Eraković Mile +6 more
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Increased Natural Killer Cell Activation in HIV-Infected Immunologic Non-Responders Correlates with CD4+ T Cell Recovery after Antiretroviral Therapy and Viral Suppression. [PDF]
PLoS ONE, 2017 The role of natural killer (NK) cell function in HIV disease especially in the setting of long-term antiretroviral therapy (ART) and viral suppression is not fully understood.
Zhenwu Luo +9 more
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Phasing out the pre-transplant cytotoxicity crossmatch: Are we missing something?
Brazilian Journal of Nephrology, 2021 Introduction: The anti-human globulin-enhanced complement-dependent cytotoxicity crossmatch (AHG-CDCXM) assay has been used to assess the presence of donor-specific antibodies (DSA) in recipient’s serum before kidney transplantation. The flow cytometric
Jamile Abud +6 more
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Immunologic difference between hypersensitivity to mosquito bite and hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection. [PDF]
PLoS ONE, 2013 Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, virus-triggered immune disease. Hypersensitivity to mosquito bite (HMB), a presentation of Chronic Active Epstein-Barr Virus infection (CAEBV), may progress to HLH.
Wen-I Lee +11 more
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Acquired Natural Killer Cell Dysfunction in the Tumor Microenvironment of Classic Hodgkin Lymphoma
Frontiers in Immunology, 2018 An understanding of interactions within the tumor microenvironment (TME) of classic Hodgkin lymphoma (cHL) has helped pave the way to novel immunotherapies that have enabled dormant and tumor-tolerant immune cells to be reactivated. The immunosuppressive
Jodi Chiu +2 more
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