Results 31 to 40 of about 30,728 (210)

Cytotoxic and Immunologic Effects of Methotrexate in Psoriasis

Journal of Investigative Dermatology, 1990
Based on recent experience that Cyclosporin A, an immunosuppressive drug, produces marked improvement in psoriasis, possible immunomodulatory activities of methotrexate (MTX) have been reviewed to look for alternate mechanisms of MTX action in psoriasis. It is generally considered that the therapeutic results of MTX in psoriasis are related to a direct
Edward W. B. Jeffes, Gerald D. Weinstein, Jerry L. McCullough   +2 more
openaire   +3 more sources

Assessment of intracanal medications cytotoxicity on L929 fibroblast cells

Bioscience Journal, 2016
This study aimed to evaluate the cytotoxicity of intracanal medications on L929 fibroblast cells at different periods of observation. The following experimental groups were studied: calcium hydroxide with camphorated paramonochlorophenol and glycerin ...
Michelle de Paula Farias, Felipe de Souza Matos, Nayane Chagas Carvalho, Roque Pacheco de Almeida, Adriano Augusto Melo de Mendonça, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Maria Amália Gonzaga Ribeiro   +6 more
doaj   +3 more sources

Cytotoxicity and genotoxicity of calcium silicate-based cements on an osteoblast lineage

Brazilian Oral Research, 2016
Several calcium silicate-based biomaterials have been developed in recent years, in addition to Mineral Trioxide Aggregate (MTA). The aim of this study was to evaluate the cytotoxicity, genotoxicity and apoptosis/necrosis in human osteoblast cells (SAOS ...
Ana Lívia GOMES-CORNÉLIO, Elisandra Márcia RODRIGUES, Leticia Boldrin MESTIERI, Thaís de Oliveira Rodrigues Sanzovo FALCOSKI, Christiane Pienna SOARES, Juliane Maria GUERREIRO-TANOMARU, Carlos ROSSA JUNIOR, Mário TANOMARU FILHO   +7 more
doaj   +1 more source

In vitro bio-immunological and cytotoxicity studies of poly(2-oxazolines) [PDF]

Journal of Materials Science: Materials in Medicine, 2011
Poly(2-oxazolines) with varying alkyl chain lengths (e.g., methyl, ethyl, aryl) and molar masses have been tested for cell cytotoxicity in vitro. A standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used for the estimation of cell viability.
Zuzana Kroneková, Lucia Paulovičová, Jozef Lustoň, Juraj Kronek, Barbara Mendrek, Ema Paulovičová   +5 more
openaire   +2 more sources

Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine

Biomaterials Research, 2023
Tissue-engineered decellularized extracellular matrix (ECM) scaffolds hold great potential to address the donor shortage as well as immunologic rejection attributed to cells in conventional tissue/organ transplantation.
Mohammadreza Kasravi, Armin Ahmadi, Amirhesam Babajani, Radman Mazloomnejad, Mohammad Reza Hatamnejad, Siavash Shariatzadeh, Soheyl Bahrami, Hassan Niknejad   +7 more
doaj   +1 more source

Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition

Journal for ImmunoTherapy of Cancer, 2022
Background Metformin slows tumor growth and progression in vitro, and in combination with chemoradiotherapy, resulted in high overall survival in patients with head and neck cancer squamous cell carcinoma (HNSCC) in our phase 1 clinical trial ...
Maria A Lehn, Trisha M Wise-Draper, Shuchi Gulati, Vinita Takiar, Sarah Palackdharry, Mario Medvedovic, Timothy Stone, Joseph Curry, Vidhya Karivedu, McKenzie Crist, Benyamin Yaniv, Michael Borchers, Bethany Fuhrman, Audrey Crago, Ubaldo Martinez-Outschoorn   +14 more
doaj   +1 more source

Stochastic model of T Cell repolarization during target elimination (I) [PDF]

, 2020
Cytotoxic T lymphocytes (T) and natural killer (NK) cells are the main cytotoxic killer cells of the human body to eliminate pathogen-infected or tumorigenic cells (i.e. target cells). Once a NK or T cell has identified a target cell, they form a tight contact zone, the immunological synapse (IS).
arxiv   +1 more source

Lung tumor microenvironment induces specific gene expression signature in intratumoral NK cells

Frontiers in Immunology, 2013
Natural Killer (NK) cells are able to recognize and kill tumor cells, however whether they contribute to tumor immunosurveillance is still debated. Our previous studies demonstrated the presence of NK cells in human lung tumors.
Mélanie eGillard-Bocquet, Mélanie eGillard-Bocquet, Mélanie eGillard-Bocquet, Charles eCaer, Charles eCaer, Charles eCaer, Nicolas eCagnard, Nicolas eCagnard, Lucile eCrozet, Lucile eCrozet, Lucile eCrozet, Mikael ePerez, Mikael ePerez, Mikael ePerez, Wolf Hervé eFridman, Wolf Hervé eFridman, Wolf Hervé eFridman, Catherine eSautes-fridman, Catherine eSautes-fridman, Catherine eSautes-fridman, Isabelle eCremer, Isabelle eCremer, Isabelle eCremer   +22 more
doaj   +1 more source

Bayesian Models and Decision Algorithms for Complex Early Phase Clinical Trials [PDF]

Statistical Science 2010, Vol. 25, No. 2, 227-244, 2010
An early phase clinical trial is the first step in evaluating the effects in humans of a potential new anti-disease agent or combination of agents. Usually called "phase I" or "phase I/II" trials, these experiments typically have the nominal scientific goal of determining an acceptable dose, most often based on adverse event probabilities.
arxiv   +1 more source

Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells [PDF]

Proceedings of the National Academy of Sciences, 2004
Membrane proteins of cytotoxic T cells specifically reorganize to form an immunological synapse (IS) on interaction with their specific target. In this paper, we investigated the redistribution of Kv1.3 channels, which are the dominant voltage-gated potassium channels, in the plasma membrane of allogen-activated human cytotoxic T lymphocytes (CTLs) on ...
György Panyi, György Vámosi, Zsolt Bacsó, Miklós Bagdány, Andrea Bodnár, Zoltán Varga, R. Gáspár, László Mátyus, Sándor Damjanovich   +8 more
openalex   +4 more sources