Results 31 to 40 of about 880,908 (352)
Biomaterials Research, 2023 Tissue-engineered decellularized extracellular matrix (ECM) scaffolds hold great potential to address the donor shortage as well as immunologic rejection attributed to cells in conventional tissue/organ transplantation.
Mohammadreza Kasravi +7 more
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Stochastic model of T Cell repolarization during target elimination (I) [PDF]
, 2020 Cytotoxic T lymphocytes (T) and natural killer (NK) cells are the main cytotoxic killer cells of the human body to eliminate pathogen-infected or tumorigenic cells (i.e. target cells). Once a NK or T cell has identified a target cell, they form a tight contact zone, the immunological synapse (IS).
arxiv +1 more source
Cancer Research, 2018 Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity.
Antoun Al Absi +14 more
semanticscholar +1 more source
Iranian Journal of Allergy, Asthma and Immunology, 2019 Stromal cell-derived factor-1 alpha (SDF-1α) has been shown to be up-regulated in a variety of malignancies. So that, its expression is associated with poor prognosis and invasiveness.
Alireza Mardomi +4 more
doaj +1 more source
Bayesian Models and Decision Algorithms for Complex Early Phase Clinical Trials [PDF]
Statistical Science 2010, Vol. 25, No. 2, 227-244, 2010 An early phase clinical trial is the first step in evaluating the effects in humans of a potential new anti-disease agent or combination of agents. Usually called "phase I" or "phase I/II" trials, these experiments typically have the nominal scientific goal of determining an acceptable dose, most often based on adverse event probabilities.
arxiv +1 more source
Lung tumor microenvironment induces specific gene expression signature in intratumoral NK cells
Frontiers in Immunology, 2013 Natural Killer (NK) cells are able to recognize and kill tumor cells, however whether they contribute to tumor immunosurveillance is still debated. Our previous studies demonstrated the presence of NK cells in human lung tumors.
Mélanie eGillard-Bocquet +22 more
doaj +1 more source
Search and capture efficiency of dynamic microtubules for centrosome relocation during IS formation [PDF]
Biophysical Journal (2019), 2019 Upon contact with antigen presenting cells (APCs) cytotoxic T lymphocytes (T cells) establish a highly organized contact zone denoted as immunological synapse (IS). The formation of the IS implies relocation of the microtubule organizing center (MTOC) towards the contact zone, which necessitates a proper connection between MTOC and IS via dynamic ...
arxiv +1 more source
Journal of Investigative Dermatology, 1988 Human vitiligo is a common depigmenting disorder that is often associated with polyendocrinopathies. The etiology of vitiligo is unknown although there is indirect evidence of a strong association between antimelanocyte antibodies in animal and human ...
David A. Norris +3 more
semanticscholar +1 more source
In vitro Cytotoxicity in Delayed-Type Hypersensitivity and Immunologic Tolerance.
Experimental Biology and Medicine, 1964 SummaryPicryl chloride was found to exert a lethal effect in vitro on leukocytes, principally lymphocytes, from guinea pigs exhibiting delayed-type skin reactivity to this hapten in the absence of antibody and complement. This reaction was found to be immunologically specific.
D. M. Lubaroff, Roy E. Ritts
openaire +3 more sources
Cytotoxicity of Reparative Endodontic Cements on Human Periodontal Ligament Stem Cells
Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022 Objective: To compare the cytotoxicity of commercial reparative endodontic cements on human periodontal ligament stem cells (hPDLSCs). Material and Methods: The culture of hPDLSCs was established.
Marlus da Silva Pedrosa +4 more
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