Results 61 to 70 of about 312,025 (347)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells

Journal of Immunology Research, 2020
Objectives. Both thymic stromal lymphopoietin (TSLP) and dendritic cells (DCs) are involved in many autoimmune diseases, but the potential roles of TSLP and DCs in bullous pemphigoid (BP) have not been clarified. We sought to explore the contributions of
Si-Zhe Li, Xin-Xing Jin, Xiao-Lei Ge, Ya-Gang Zuo, Hong-Zhong Jin   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Immunological benefits by ginseng through reciprocal regulation of Th17 and Treg cells during cyclosporine-induced immunosuppression

Journal of Ginseng Research, 2016
Background: It is not clear whether ginseng affects cyclosporine A (CsA)-induced desirable immunosuppressive action. In this study, we evaluated the immunological influence of combined treatment of ginseng with CsA. Methods: Using CD4+ T cells from mouse
Seong Beom Heo, Sun Woo Lim, Joo Yeon Jhun, Mi La Cho, Byung Ha Chung, Chul Woo Yang   +5 more
doaj   +1 more source

Retroperitoneal fibrosis: a case of a patient (63y/o) treated with low-dose methotrexate (MTX) and 6-methylprednisolone (6-MP) [PDF]

, 2018
Retroperitoneal fibrosis (RPF), is a rare fibroinflammatory disease. The pathogenesis of RPF is still unclear and numerous theories have been reported such as environmental factors, immunologic process, genetic component, local inflammation and advanced
A. Santoro, A. Sili Scavalli, N. Galea, R. Cirocchi, R. Poscia, ROSIELLO, FRANCESCO, V. Riccieri   +6 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy. [PDF]

, 2013
ObjectivesTo examine the impact of serum-derived bovine immunoglobulin, an oral medical food known to neutralize bacterial antigen and reduce intestinal inflammation, on restoration of mucosal immunity and gastrointestinal function in individuals with ...
Albanese, Anthony, Asmuth, David M, Devaraj, Sridevi, Douek, Daniel C, Flynn, Neil M, Garcia, Juan-Carlos, Knight, Thomas H, Ma, Zhong-Min, Miller, Christopher J, Sandler, Netanya G, Tsuchida, Emily, Wu, Tsung-Teh, Yotter, Tammy   +12 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

International consensus on (ICON) anaphylaxis [PDF]

, 2014
ICON: Anaphylaxis provides a unique perspective on the principal evidence-based anaphylaxis guidelines developed and published independently from 2010 through 2014 by four allergy/immunology organizations.
Alvarez-Twose, Antonella Muraro, Arga, Armstrong, Arroabarren, Aziz Sheikh, Barnett, Bauer, Belhocine, Ben-Shoshan, Bilo, Bonadonna, Boyce, Boyle, Brockow, Brouwers, Brown, Brown, Brown, Brown, Caffarelli, Camargo, Campbell, Campbell, Campbell, Cetinkaya, Chad, Chiang, Choo, Cox, Cummings, Dana V. Wallace, de Silva, Dhami, Duke, Edwards, Ellis, Enarson, F. Estelle R. Simons, Field, Fineman, Fleischer, Gibbison, Gibbs, Golden, Gonzalez-Perez, Grabenhenrich, Graham Roberts, Harduar-Morano, Heinzerling, Hoffer, Iribarren, Jang, Jones, Kalesnikoff, Kelleher, Khodoun, Kim, Kim, Lafuente, Landsman-Blumberg, Ledit R.F. Ardusso, Lee, Li, Lieberman, Liew, Liew, Liu, Lotvall, Ludman, Lynette P. Shek, M Beatrice Bilò, Margitta Worm, Mario Sanchez-Borges, Mertes, Minciullo, Motohiro Ebisawa, Muller, Muraro, Ng, Nicklas, Noimark, Nurmatov, Panesar, Park, Perel, Phil Lieberman, Raimer, Ralston, Renaudin, Ribeiro-Vaz, Richard F. Lockey, Rudders, Rudders, Rueff, Rueff, Sala-Cunill, Sampson, Sampson, Sanchez-Borges, Sanchez-Borges, Schneider, Sheikh, Sheikh, Shemesh, Shen, Sicherer, Sicherer, Simons, Simons, Simons, Simons, Simons, Simons, Simons, Simons, Simons, Sole, Stoevesandt, Strohmeier, Takahashi, Tanno, Techapornroong, Tejedor Alonso, Thong, Topal, Triggiani, Vadas, Vadas, Vale, Valent, Vereda, Victoria Cardona, Wolbing, Wood, Wood, Worm, Yehia M. El-Gamal   +137 more
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source